CGT

1,342개 · ADC 890 · Antibody 4097 · CGT 2985 · 다음 갱신 D-6 · 마지막 9월 2일

PopularRecently updatedCuratedMost trialsNeeds refreshORRLatestPhase 3FDA approved1,342 programs
CGTCurated CoreFDAKiteApproved

axicabtagene ciloleucel (Yescarta, axi-cel)

LBCL, FL · CD19

#CD19#CGT#Approved#FDA-approved#BioJungboMoa-pick+5
Trials 68Status Approved
CGTCurated CoreFDANovartisApproved

tisagenlecleucel (Kymriah, tisa-cel)

ALL, DLBCL, FL · CD19

#CD19#CGT#Approved#FDA-approved#BioJungboMoa-pick+5
Trials 48Status Approved
CGTCurated CoreFDAIovance BiotherapeuticsApproved

lifileucel (Amtagvi, LN-144, tumor infiltrating lymphocyte)

Unresectable or metastatic melanoma after PD-1 blockade · Polyclonal tumor neoantigens (TIL)

#PolyclonaltumorneoantigensTIL#CGT#Approved#FDA-approved#BioJungboMoa-pick+5
Trials 47Status Approved
CGTCurated CoreFDAJohnson & JohnsonApproved

ciltacabtagene autoleucel (Carvykti, cilta-cel, LCAR-B38M, JNJ-68284528)

Relapsed or refractory multiple myeloma · BCMA

#BCMA#CGT#Approved#FDA-approved#BioJungboMoa-pick+5
Trials 29Status Approved
CGTAAVCurated CoreFDANovartisApproved

onasemnogene abeparvovec (Zolgensma, AVXS-101, onasemnogene abeparvovec-xioi)

Spinal muscular atrophy (SMA) Type 1–3, pediatric · SMN1 (AAV9)

#SMN1AAV9#CGT#Approved#FDA-approved#BioJungboMoa-pick+5
Trials 28Status Approved
CGTAAVCurated CoreFDASarepta TherapeuticsApproved

delandistrogene moxeparvovec (Elevidys, SRP-9001, delandistrogene moxeparvovec-rokl)

Duchenne muscular dystrophy (DMD) — ambulatory / label-expanded populations · Micro-dystrophin (AAVrh74)

#Micro-dystrophinAAVrh74#CGT#Approved#FDA-approved#BioJungboMoa-pick+5
Trials 12Status Approved
CGTCurated CoreFDAFerring PharmaceuticalsApproved

nadofaragene firadenovec (Adstiladrin, rAd-IFNα/Syn3, nadofaragene firadenovec-vncg)

High-risk BCG-unresponsive non-muscle invasive bladder cancer (NMIBC) · IFNα2b (adenoviral)

#IFN2badenoviral#CGT#Approved#FDA-approved#BioJungboMoa-pick+5
Trials 10Status Approved
CGTCurated CoreFDAVertexApproved

exagamglogene autotemcel (Casgevy, exa-cel, CTX001)

Sickle cell disease with recurrent VOCs; transfusion-dependent β-thalassemia · BCL11A enhancer (CRISPR/Cas9) → HbF

#BCL11AenhancerCRISPRCas9HbF#CGT#Approved#FDA-approved#BioJungboMoa-pick+5
Trials 9Status Approved
CGTAAVCurated CoreFDABioMarinApproved

valoctocogene roxaparvovec (Roctavian, BMN 270, valoctocogene roxaparvovec-rvox)

Severe hemophilia A in adults · Factor VIII (AAV5)

#FactorVIIIAAV5#CGT#Approved#FDA-approved#BioJungboMoa-pick+5
Trials 8Status Approved
CGTAAVCurated CoreFDACSL BehringApproved

etranacogene dezaparvovec (Hemgenix, AMT-061, CSL222, etranacogene dezaparvovec-drlb)

Hemophilia B (congenital Factor IX deficiency) in adults · Factor IX (AAV5 Padua)

#FactorIXAAV5Padua#CGT#Approved#FDA-approved#BioJungboMoa-pick+5
Trials 7Status Approved
CGTAAVCurated CoreFDASpark TherapeuticsApproved

voretigene neparvovec (Luxturna, AAV2-hRPE65v2, voretigene neparvovec-rzyl)

Inherited retinal dystrophy due to confirmed biallelic RPE65 mutations · RPE65 (AAV2)

#RPE65AAV2#CGT#Approved#FDA-approved#BioJungboMoa-pick+5
Trials 7Status Approved
CGTCurated CoreFDAOrchard Therapeutics (Kyowa Kir…Approved

atidarsagene autotemcel (Lenmeldy, OTL-200, Libmeldy, arsa-cel)

Pre-symptomatic and early-symptomatic metachromatic leukodystrophy · ARSA (arylsulfatase A) gene

#ARSAarylsulfataseAgene#CGT#Approved#FDA-approved#BioJungboMoa-pick+5
Trials 3Status Approved
CGTCurated CoreFDAbluebird bioApproved

lovotibeglogene autotemcel (Lyfgenia, lovo-cel, bb1111)

Sickle cell disease with recurrent vaso-occlusive events · βA-T87Q-globin (lentiviral)

#A-T87Q-globinlentiviral#CGT#Approved#FDA-approved#BioJungboMoa-pick+5
Trials 2Status Approved
CGTLimited DataGlaxoSmithKlinePhase 1

19 (T2, 19, 19(T2)28z1xx TRAC T cell)

B-Cell Lymphoma; Large B-cell Lymphoma · B-Cell Lymphoma

#B-CellLymphoma#CGT#Phase1#Popular#cell-gene-therapy+5
Trials 340Status Recruiting
CGTLimited DatastaleCSL BehringPhase 3

FIX (Factor IX, Factor IX (FIX))

Hemophilia B · Hemophilia B

#HemophiliaB#CGT#Phase3#Popular#cell-gene-therapy+4
Trials 225Status Active
CGTLimited DatastaleThomas Martin, MDPhase 1

Chimeric Antigen Receptor T cells (CAR-T, Chimeric Antigen Receptor T cells, Chimeric Antigen Receptor T cells (CAR-T) Targeting BCMA)

Multiple Myeloma; Recurrent Multiple Myeloma · BCMA

#BCMA#CGT#Phase1#Popular#cell-gene-therapy+5
Trials 211Status Discontinued
CGTLimited DatastaleTakedaPhase 1

19 (T2, 19, 19(T2)28z1xx CAR T cells)

Diffuse Large B Cell Lymphoma; Primary Mediastinal Large B Cell Lymphoma · Diffuse Large B Cell Lymphoma

#DiffuseLargeBCellLymphoma#CGT#Phase1#Popular#cell-gene-therapy+4
Trials 182Status Recruiting
CGTStandard DatabasestaleJanssen Research & Development,…Phase 3

AA (Abiraterone acetate, Abiraterone acetate (AA))

Metastatic Castration-sensitive Prostate Cancer · Metastatic Castration-sensitive Prostate

#MetastaticCastration-sensitivePr#CGT#Phase3#Popular#cell-gene-therapy+4
Trials 178Status Recruiting
CGTStandard DatabasestaleAstraZenecaPhase 2

autologous CD19-directed chimeric antigen receptor (CAR, autologous CD19-directed chimeric antigen receptor, autologous CD19-directed chimeric antigen receptor (CAR) T-cells)

Relapsed Non Hodgkin Lymphoma; Relapsed Adult ALL · CD19

#CD19#CGT#Phase2#Popular#cell-gene-therapy+5
Trials 154Status Recruiting
CGTStandard DatabasestaleAmgenPhase 3

Asparaginase Erwinia chrysanthemi (Asparaginase Erwinia chrysanthemi, Asparaginase Erwinia chrysanthemi (recombinant)-rywn, recombinant)

Acute Lymphoblastic Leukemia; Acute Lymphoblastic Lymphoma · Acute Lymphoblastic Leukemia

#AcuteLymphoblasticLeukemia#CGT#Phase3#Popular#cell-gene-therapy+5
Trials 134Status Recruiting

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