BeOne Medicines
5-FU(BeOne Medicines)은 Metastatic Colorectal Cancer (CRC) 표적 ADC로, Metastatic Colorectal Cancer 영역에서 개발·상용화 중입니다. 작용기전: target tumor sites, thereby significantly suppressing CRC growth through the induction of ferroptosis via regulating the FGFR3/PI3K/AKt signaling pathway. Phase 3 후기 임상 단계입니다. 대표 임상 효능: ORR 58% (ClinicalTrials.gov NCT04662710). 차별점: novel biomarkers and targeted strategies.
Metastatic Colorectal Cancer (CRC)
Metastatic Colorectal Cancer
Recruiting
gene therapy
govitecan in a patient with brain metastases from
lentiviral gene therapy
novel biomarkers and targeted strategies
target tumor sites, thereby significantly suppressing CRC growth through the induction of ferroptosis via regulating the FGFR3/PI3K/AKt signaling pathway
t cells to oxaliplatin (L-OHP) and 5-fluorouracil (5FU), an effect that was reversible upon PI3K pathway activation
apoptosis, crypt disorganization, inflammatory-cell infiltration, oxidative-injury, and disrupted tight junctions with barrier dy
biomarkers offer a promising, non-invasive approach to personalizing treatment strategies potentially enhanci
Resistance to 5-Fluorouracil and Oxaliplatin in Colorectal Cancer Cells
차트 로드 중…
임상시험이 많습니다. 임상시험 탭에서 Phase/Status 필터·검색을 사용하세요.
수집된 임상 필드(phase, status, endpoint 등) 기반 자동 요약입니다.
BeOne Medicines
5-FU(BeOne Medicines)은 Metastatic Colorectal Cancer (CRC) 표적 ADC로, Metastatic Colorectal Cancer 영역에서 개발·상용화 중입니다. 작용기전: target tumor sites, thereby significantly suppressing CRC growth through the induction of ferroptosis via regulating the FGFR3/PI3K/AKt signaling pathway. Phase 3 후기 임상 단계입니다. 대표 임상 효능: ORR 58% (ClinicalTrials.gov NCT04662710). 차별점: novel biomarkers and targeted strategies.
Metastatic Colorectal Cancer (CRC)
Metastatic Colorectal Cancer
Recruiting
gene therapy
govitecan in a patient with brain metastases from
lentiviral gene therapy
novel biomarkers and targeted strategies
target tumor sites, thereby significantly suppressing CRC growth through the induction of ferroptosis via regulating the FGFR3/PI3K/AKt signaling pathway
t cells to oxaliplatin (L-OHP) and 5-fluorouracil (5FU), an effect that was reversible upon PI3K pathway activation
apoptosis, crypt disorganization, inflammatory-cell infiltration, oxidative-injury, and disrupted tight junctions with barrier dy
biomarkers offer a promising, non-invasive approach to personalizing treatment strategies potentially enhanci
Resistance to 5-Fluorouracil and Oxaliplatin in Colorectal Cancer Cells
차트 로드 중…
임상시험이 많습니다. 임상시험 탭에서 Phase/Status 필터·검색을 사용하세요.
수집된 임상 필드(phase, status, endpoint 등) 기반 자동 요약입니다.