구조모아 (StructureMoa)항암 chemical structure spider web
방문프로그램 상세에서 관심 등록 후 2개 이상 모으면 여기서 한 번에 비교할 수 있습니다.
표가 넓으면 좌우로 스크롤하세요. 핵심 비교 모드에서는 중요 항목만 표시됩니다.
| 항목 | ||||
|---|---|---|---|---|
Overview Program | Humira (adalimumab) | Stelara (ustekinumab) | Skyrizi (risankizumab-rzaa) | Tremfya (guselkumab) |
Overview Company | AbbVie | Johnson & Johnson | AbbVie | Johnson & Johnson |
Overview Modality | ANTIBODY | ANTIBODY | ANTIBODY | ANTIBODY |
Overview Target | TNF-α | IL-12 / IL-23 (p40) | IL-23 p19 | IL-23 p19 |
Overview Indication | Rheumatoid arthritis, psoriasis, Crohn's disease, ulcerative colitis, axial SpA | Psoriasis, psoriatic arthritis, Crohn's disease, ulcerative colitis | Plaque psoriasis, PsA, Crohn's disease, ulcerative colitis | Plaque psoriasis, psoriatic arthritis, ulcerative colitis, Crohn's disease |
Overview Phase | APPROVED | APPROVED | APPROVED | APPROVED |
Overview Status | APPROVED | APPROVED | APPROVED | APPROVED |
Overview Content status | Curated Core | Curated Core | Curated Core | Curated Core |
Overview Data Confidence | Data Confidence · High | Data Confidence · High | Data Confidence · High | Data Confidence · High |
Overview Development Signal | Development Signal · Established | Development Signal · Established | Development Signal · Established | Development Signal · Established |
Overview Approval status | FDA approved | FDA approved | FDA approved | FDA approved |
Positioning Key differentiator | novel object recognition test | Novel therapeutic avenues, including TYK2 and HDAC inhibitors, as well as nanotechnology-based delivery systems, show encoura | Novel therapeutic avenues, including TYK2 and HDAC inhibitors, as well as nanotechnology-based delivery systems, show encoura | Leaving IL-12 intact preserves Th1 antimicrobial immunity while shutting down the Th17 axis, which is why durability is high and infection signals are low. |
Positioning Known limitation | Anti-drug antibodies, TNF-independent inflammation, and immunogenicity lowering trough levels. | IL-23 axis escape, anti-drug antibodies, and non-IL-12/23 inflammation. | IL-17 independent disease and immunogenicity. | Anti-drug antibodies are rare; non-IL-23-driven fibrostenotic disease does not respond. |
Positioning Development positioning | — | — | — | IL-23 class benchmark alongside Skyrizi, now with the broadest IBD label progression. |
MoA Mechanism | Adalimumab binds specifically to TNF-α and blocks its interaction with p55 and p75 cell-surface TNF receptors, neutralizing TNF-mediated inflammatory cascades (IL-6, adhesion molecules, acute-phase proteins). | Ustekinumab binds the p40 subunit shared by IL-12 and IL-23, preventing their interaction with IL-12Rβ1 receptor and downstream Th1/Th17 differentiation and cytokine production. | Risankizumab selectively binds IL-23 p19 subunit, blocking IL-23 interaction with IL-23R and downstream Th17 pathway (IL-17A/F, IL-22). | Neutralizes IL-23 by binding p19, blocking IL-23R signaling and downstream Th17/Th22 differentiation, IL-17 production, and tissue inflammation in skin, joints, and gut mucosa. |
MoA Biomarker | CRP, ESR, disease-specific scores (DAS28, PASI, Mayo for IBD). | biomarkers but require external validation in independent cohorts | PASI, sPGA, IBD endoscopic scores. | PASI/IGA in psoriasis, ACR20 in PsA, endoscopic improvement and fecal calprotectin in IBD. |
PK/PD Half-life | ~14–19 days (SC) | 19 h | 28 h | ~15–18 days |
PK/PD Species | Rat, xenografts, which corroborat, CRP reduction, clinical remission scores | Mouse, Skin clearance (PASI75/90), endoscopic response in IBD | Mouse | Cynomolgus monkey, PASI 90/100, ACR20/50, endoscopic remission, serum IL-17A/IL-22 |
PK/PD Animal (cat.) | Rat | Mouse | Mouse | Human, NHP |
PK/PD Experiment | pd | Pharmacokinetic | Pharmacokinetic | Pharmacokinetic |
Toxicology Species | Cynomolgus monkey, Rat, xenografts, which corroborat | Cynomolgus monkey, Mouse | Cynomolgus monkey, Mouse | Mouse, Pig |
Toxicology Animal (cat.) | NHP | — | — | — |
Toxicology Major finding | Serious infections (TB reactivation, invasive fungal), malignancy risk signal, injection-site reactions, and rare demyelinating events. | Infections, reversible posterior leukoencephalopathy syndrome (rare), hypersensitivity. | Upper respiratory infections, headache, fatigue; low TB reactivation vs TNF class. | Upper respiratory infection, headache, and injection-site reactions dominate. Serious infection and malignancy signals have stayed low across long-term psoriasis follow-up. |
Toxicology CRS | N/A | N/A | N/A | N/A |
Clinical Safety signal | Serious infections (TB reactivation, invasive fungal), malignancy risk signal, injection-site reactions, and rare demyelinating events. | Infections, reversible posterior leukoencephalopathy syndrome (rare), hypersensitivity. | Upper respiratory infections, headache, fatigue; low TB reactivation vs TNF class. | Upper respiratory infection, headache, and injection-site reactions dominate. Serious infection and malignancy signals have stayed low across long-term psoriasis follow-up. |
Clinical Selected reported efficacy | — | PASI75 67% | — | — |
Clinical PASI75 | — | 67% | — | — |
Clinical Result source | ClinicalTrials.gov NCT02405780 | PHOENIX | — | — |
Clinical Program phase | APPROVED | APPROVED | APPROVED | APPROVED |
Clinical Trial activity | No active/completed counts | No active/completed counts | No active/completed counts | No active/completed counts |
Clinical Trial ref | NCT02405780 | PHOENIX | — | — |
Preclinical Animal (cat.) | — | — | Mouse | Mouse |
프로그램 상세에서 관심 등록 후 2개 이상 모으면 여기서 한 번에 비교할 수 있습니다.
표가 넓으면 좌우로 스크롤하세요. 핵심 비교 모드에서는 중요 항목만 표시됩니다.
| 항목 | ||||
|---|---|---|---|---|
Overview Program | Humira (adalimumab) | Stelara (ustekinumab) | Skyrizi (risankizumab-rzaa) | Tremfya (guselkumab) |
Overview Company | AbbVie | Johnson & Johnson | AbbVie | Johnson & Johnson |
Overview Modality | ANTIBODY | ANTIBODY | ANTIBODY | ANTIBODY |
Overview Target | TNF-α | IL-12 / IL-23 (p40) | IL-23 p19 | IL-23 p19 |
Overview Indication | Rheumatoid arthritis, psoriasis, Crohn's disease, ulcerative colitis, axial SpA | Psoriasis, psoriatic arthritis, Crohn's disease, ulcerative colitis | Plaque psoriasis, PsA, Crohn's disease, ulcerative colitis | Plaque psoriasis, psoriatic arthritis, ulcerative colitis, Crohn's disease |
Overview Phase | APPROVED | APPROVED | APPROVED | APPROVED |
Overview Status | APPROVED | APPROVED | APPROVED | APPROVED |
Overview Content status | Curated Core | Curated Core | Curated Core | Curated Core |
Overview Data Confidence | Data Confidence · High | Data Confidence · High | Data Confidence · High | Data Confidence · High |
Overview Development Signal | Development Signal · Established | Development Signal · Established | Development Signal · Established | Development Signal · Established |
Overview Approval status | FDA approved | FDA approved | FDA approved | FDA approved |
Positioning Key differentiator | novel object recognition test | Novel therapeutic avenues, including TYK2 and HDAC inhibitors, as well as nanotechnology-based delivery systems, show encoura | Novel therapeutic avenues, including TYK2 and HDAC inhibitors, as well as nanotechnology-based delivery systems, show encoura | Leaving IL-12 intact preserves Th1 antimicrobial immunity while shutting down the Th17 axis, which is why durability is high and infection signals are low. |
Positioning Known limitation | Anti-drug antibodies, TNF-independent inflammation, and immunogenicity lowering trough levels. | IL-23 axis escape, anti-drug antibodies, and non-IL-12/23 inflammation. | IL-17 independent disease and immunogenicity. | Anti-drug antibodies are rare; non-IL-23-driven fibrostenotic disease does not respond. |
Positioning Development positioning | — | — | — | IL-23 class benchmark alongside Skyrizi, now with the broadest IBD label progression. |
MoA Mechanism | Adalimumab binds specifically to TNF-α and blocks its interaction with p55 and p75 cell-surface TNF receptors, neutralizing TNF-mediated inflammatory cascades (IL-6, adhesion molecules, acute-phase proteins). | Ustekinumab binds the p40 subunit shared by IL-12 and IL-23, preventing their interaction with IL-12Rβ1 receptor and downstream Th1/Th17 differentiation and cytokine production. | Risankizumab selectively binds IL-23 p19 subunit, blocking IL-23 interaction with IL-23R and downstream Th17 pathway (IL-17A/F, IL-22). | Neutralizes IL-23 by binding p19, blocking IL-23R signaling and downstream Th17/Th22 differentiation, IL-17 production, and tissue inflammation in skin, joints, and gut mucosa. |
MoA Biomarker | CRP, ESR, disease-specific scores (DAS28, PASI, Mayo for IBD). | biomarkers but require external validation in independent cohorts | PASI, sPGA, IBD endoscopic scores. | PASI/IGA in psoriasis, ACR20 in PsA, endoscopic improvement and fecal calprotectin in IBD. |
PK/PD Half-life | ~14–19 days (SC) | 19 h | 28 h | ~15–18 days |
PK/PD Species | Rat, xenografts, which corroborat, CRP reduction, clinical remission scores | Mouse, Skin clearance (PASI75/90), endoscopic response in IBD | Mouse | Cynomolgus monkey, PASI 90/100, ACR20/50, endoscopic remission, serum IL-17A/IL-22 |
PK/PD Animal (cat.) | Rat | Mouse | Mouse | Human, NHP |
PK/PD Experiment | pd | Pharmacokinetic | Pharmacokinetic | Pharmacokinetic |
Toxicology Species | Cynomolgus monkey, Rat, xenografts, which corroborat | Cynomolgus monkey, Mouse | Cynomolgus monkey, Mouse | Mouse, Pig |
Toxicology Animal (cat.) | NHP | — | — | — |
Toxicology Major finding | Serious infections (TB reactivation, invasive fungal), malignancy risk signal, injection-site reactions, and rare demyelinating events. | Infections, reversible posterior leukoencephalopathy syndrome (rare), hypersensitivity. | Upper respiratory infections, headache, fatigue; low TB reactivation vs TNF class. | Upper respiratory infection, headache, and injection-site reactions dominate. Serious infection and malignancy signals have stayed low across long-term psoriasis follow-up. |
Toxicology CRS | N/A | N/A | N/A | N/A |
Clinical Safety signal | Serious infections (TB reactivation, invasive fungal), malignancy risk signal, injection-site reactions, and rare demyelinating events. | Infections, reversible posterior leukoencephalopathy syndrome (rare), hypersensitivity. | Upper respiratory infections, headache, fatigue; low TB reactivation vs TNF class. | Upper respiratory infection, headache, and injection-site reactions dominate. Serious infection and malignancy signals have stayed low across long-term psoriasis follow-up. |
Clinical Selected reported efficacy | — | PASI75 67% | — | — |
Clinical PASI75 | — | 67% | — | — |
Clinical Result source | ClinicalTrials.gov NCT02405780 | PHOENIX | — | — |
Clinical Program phase | APPROVED | APPROVED | APPROVED | APPROVED |
Clinical Trial activity | No active/completed counts | No active/completed counts | No active/completed counts | No active/completed counts |
Clinical Trial ref | NCT02405780 | PHOENIX | — | — |
Preclinical Animal (cat.) | — | — | Mouse | Mouse |
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