타깃 · 모달리티 · 임상 근거 · 비임상 맥락으로 최대 5개 프로그램을 나란히 비교합니다. · 자동 수집 갱신 권장 · 9월 2일
현재 선택: 5개 · 임상 갱신 필요 5개 · Data Tier에서 열림
프로그램 상세에서 관심 등록 후 2개 이상 모으면 여기서 한 번에 비교할 수 있습니다.
표가 넓으면 좌우로 스크롤하세요. 핵심 비교 모드에서는 중요 항목만 표시됩니다.
| 항목 | mirvetuximab soravtansine-gynx (Elahere, IMGN853, mirvetuximab-soravtansine-gynx) AbbVie / ImmunoGen·FRα (folate receptor alpha) 32 trials | Gemcitabine Hydrochloride (Gemcitabine Hydrochloride) K-Group, Beta, Inc., a wholly owne…·FRα 165 trials | |||
|---|---|---|---|---|---|
Overview Program | Elahere (mirvetuximab soravtansine-gynx) | Cyclosporine | mycophenolate mofetil | tacrolimus | Gemcitabine Hydrochloride |
Overview Company | AbbVie / ImmunoGen | Amsterdam Molecular Therapeutics | Amsterdam Molecular Therapeutics | Tolera Therapeutics, Inc | K-Group, Beta, Inc., a wholly owned subsidiary of Zentalis Pharmaceuticals, Inc |
Overview Modality | ADC | ANTIBODY | ANTIBODY | ANTIBODY | ADC |
Overview Target | FRα (folate receptor alpha) | FRα | FRα | FRα | FRα |
Overview Indication | FRα-positive platinum-resistant ovarian, fallopian tube, or primary peritoneal cancer | Chronic Myeloproliferative Disorders; Leukemia | Chronic Myeloproliferative Disorders; Leukemia | Leukemia; Lymphoma | Fallopian Tube Carcinosarcoma; Fallopian Tube Clear Cell Adenocarcinoma |
Overview Phase | APPROVED | PHASE_3 | PHASE_3 | PHASE_2 | PHASE_2 |
Overview Status | APPROVED | ACTIVE | ACTIVE | ACTIVE | ACTIVE |
Overview Content status | Curated Core | Limited Data | Limited Data | Limited Data | Limited Data |
Overview Data Confidence | Editorial scope · Curated Core | Editorial scope · limited data | Editorial scope · limited data | Editorial scope · limited data | Editorial scope · limited data |
Overview Development Signal | Development Signal · Established | Development Signal · Emerging | Development Signal · Emerging | Development Signal · Emerging | Development Signal · Emerging |
Overview Approval status | FDA approved | Investigational | Investigational | Investigational | Investigational |
Positioning Key differentiator | FRα is overexpressed in ovarian cancer but sparse in normal tissue, and the label requires IHC-confirmed expression. | — | — | — | — |
Positioning Known limitation | FRα downregulation and multidrug-resistance transporter upregulation. | — | — | — | — |
Positioning Development positioning | 2L–4L platinum-resistant | — | — | — | — |
Technology Payload | DM4 (maytansinoid, tubulin inhibitor) | — | — | — | — |
Technology Linker | Cleavable sulfo-SPDB disulfide, DAR ~3.5 | — | — | — | linker-payload technologies |
Technology DAR | DAR 3.5 | — | — | — | — |
MoA Mechanism | Binds FRα, internalizes via receptor-mediated endocytosis, and releases DM4 after disulfide reduction; tubulin disruption causes mitotic arrest, with lipophilic S-methyl-DM4 giving bystander activity. | target interactions (TNF, NF‑κB, STAT3, IL-1β, AKT1, IL-6, Src) and pathways (IL-17, PI3K-Akt, TNF signaling | Mycophenolate mofetil (MMF) is absorbed following oral administration and hydrolyzed to mycophenolic acid (MPA), the active metabolite | Tacrolimus binds to an intracellular protein, FKBP-12 | of ProAgio, which includes reducing hypoxia and modulating TME |
MoA Biomarker | FRα IHC (VENTANA FOLR1 RxDx), PS2+ scoring with ≥75% of tumor cells staining. | biomarker data support an endotype-driven approach: higher total immunoglobulin E (IgE) is generally associat | CD20+ B cell levels rapidly declining to extremely low | biomarkers of inflammation, and histopathological findings | HER2 expression |
Toxicology Species | Rat | — | — | — | — |
Toxicology Major finding | Boxed warning for ocular toxicity — keratopathy, blurred vision, and dry eye. Peripheral neuropathy, nausea, and fatigue are also common. | — | — | — | — |
Toxicology CRS | N/A | — | — | — | — |
Clinical Safety signal | Boxed warning for ocular toxicity — keratopathy, blurred vision, and dry eye. Peripheral neuropathy, nausea, and fatigue are also common. | — | — | — | — |
Clinical Selected reported efficacy | ORR 42% | — | — | — | — |
Clinical Reported ORR | 42% vs 16% (chemotherapy; rounded in NCI report) | — | — | — | — |
Clinical Reported PFS | 5.6 months vs 4.0 months (chemotherapy) | — | — | — | — |
Clinical Reported OS | 16.5 months vs 12.8 months (chemotherapy) | — | — | — | — |
Clinical Result source | NCI approval analysis 2024 — MIRASOL (NCT04209855) | — | — | — | — |
Clinical Program phase | APPROVED | PHASE_3 | PHASE_3 | PHASE_2 | PHASE_2 |
Clinical Trial activity | No active/completed counts | No active/completed counts | No active/completed counts | No active/completed counts | No active/completed counts |
Clinical Trial ref | NCT04209855 | — | — | — | — |
Preclinical Animal (cat.) | — | Mouse | — | — | — |
타깃 · 모달리티 · 임상 근거 · 비임상 맥락으로 최대 5개 프로그램을 나란히 비교합니다. · 자동 수집 갱신 권장 · 9월 2일
현재 선택: 5개 · 임상 갱신 필요 5개 · Data Tier에서 열림
프로그램 상세에서 관심 등록 후 2개 이상 모으면 여기서 한 번에 비교할 수 있습니다.
표가 넓으면 좌우로 스크롤하세요. 핵심 비교 모드에서는 중요 항목만 표시됩니다.
| 항목 | mirvetuximab soravtansine-gynx (Elahere, IMGN853, mirvetuximab-soravtansine-gynx) AbbVie / ImmunoGen·FRα (folate receptor alpha) 32 trials | Gemcitabine Hydrochloride (Gemcitabine Hydrochloride) K-Group, Beta, Inc., a wholly owne…·FRα 165 trials | |||
|---|---|---|---|---|---|
Overview Program | Elahere (mirvetuximab soravtansine-gynx) | Cyclosporine | mycophenolate mofetil | tacrolimus | Gemcitabine Hydrochloride |
Overview Company | AbbVie / ImmunoGen | Amsterdam Molecular Therapeutics | Amsterdam Molecular Therapeutics | Tolera Therapeutics, Inc | K-Group, Beta, Inc., a wholly owned subsidiary of Zentalis Pharmaceuticals, Inc |
Overview Modality | ADC | ANTIBODY | ANTIBODY | ANTIBODY | ADC |
Overview Target | FRα (folate receptor alpha) | FRα | FRα | FRα | FRα |
Overview Indication | FRα-positive platinum-resistant ovarian, fallopian tube, or primary peritoneal cancer | Chronic Myeloproliferative Disorders; Leukemia | Chronic Myeloproliferative Disorders; Leukemia | Leukemia; Lymphoma | Fallopian Tube Carcinosarcoma; Fallopian Tube Clear Cell Adenocarcinoma |
Overview Phase | APPROVED | PHASE_3 | PHASE_3 | PHASE_2 | PHASE_2 |
Overview Status | APPROVED | ACTIVE | ACTIVE | ACTIVE | ACTIVE |
Overview Content status | Curated Core | Limited Data | Limited Data | Limited Data | Limited Data |
Overview Data Confidence | Editorial scope · Curated Core | Editorial scope · limited data | Editorial scope · limited data | Editorial scope · limited data | Editorial scope · limited data |
Overview Development Signal | Development Signal · Established | Development Signal · Emerging | Development Signal · Emerging | Development Signal · Emerging | Development Signal · Emerging |
Overview Approval status | FDA approved | Investigational | Investigational | Investigational | Investigational |
Positioning Key differentiator | FRα is overexpressed in ovarian cancer but sparse in normal tissue, and the label requires IHC-confirmed expression. | — | — | — | — |
Positioning Known limitation | FRα downregulation and multidrug-resistance transporter upregulation. | — | — | — | — |
Positioning Development positioning | 2L–4L platinum-resistant | — | — | — | — |
Technology Payload | DM4 (maytansinoid, tubulin inhibitor) | — | — | — | — |
Technology Linker | Cleavable sulfo-SPDB disulfide, DAR ~3.5 | — | — | — | linker-payload technologies |
Technology DAR | DAR 3.5 | — | — | — | — |
MoA Mechanism | Binds FRα, internalizes via receptor-mediated endocytosis, and releases DM4 after disulfide reduction; tubulin disruption causes mitotic arrest, with lipophilic S-methyl-DM4 giving bystander activity. | target interactions (TNF, NF‑κB, STAT3, IL-1β, AKT1, IL-6, Src) and pathways (IL-17, PI3K-Akt, TNF signaling | Mycophenolate mofetil (MMF) is absorbed following oral administration and hydrolyzed to mycophenolic acid (MPA), the active metabolite | Tacrolimus binds to an intracellular protein, FKBP-12 | of ProAgio, which includes reducing hypoxia and modulating TME |
MoA Biomarker | FRα IHC (VENTANA FOLR1 RxDx), PS2+ scoring with ≥75% of tumor cells staining. | biomarker data support an endotype-driven approach: higher total immunoglobulin E (IgE) is generally associat | CD20+ B cell levels rapidly declining to extremely low | biomarkers of inflammation, and histopathological findings | HER2 expression |
Toxicology Species | Rat | — | — | — | — |
Toxicology Major finding | Boxed warning for ocular toxicity — keratopathy, blurred vision, and dry eye. Peripheral neuropathy, nausea, and fatigue are also common. | — | — | — | — |
Toxicology CRS | N/A | — | — | — | — |
Clinical Safety signal | Boxed warning for ocular toxicity — keratopathy, blurred vision, and dry eye. Peripheral neuropathy, nausea, and fatigue are also common. | — | — | — | — |
Clinical Selected reported efficacy | ORR 42% | — | — | — | — |
Clinical Reported ORR | 42% vs 16% (chemotherapy; rounded in NCI report) | — | — | — | — |
Clinical Reported PFS | 5.6 months vs 4.0 months (chemotherapy) | — | — | — | — |
Clinical Reported OS | 16.5 months vs 12.8 months (chemotherapy) | — | — | — | — |
Clinical Result source | NCI approval analysis 2024 — MIRASOL (NCT04209855) | — | — | — | — |
Clinical Program phase | APPROVED | PHASE_3 | PHASE_3 | PHASE_2 | PHASE_2 |
Clinical Trial activity | No active/completed counts | No active/completed counts | No active/completed counts | No active/completed counts | No active/completed counts |
Clinical Trial ref | NCT04209855 | — | — | — | — |
Preclinical Animal (cat.) | — | Mouse | — | — | — |
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