타깃 · 모달리티 · 임상 근거 · 비임상 맥락으로 최대 5개 프로그램을 나란히 비교합니다. · 자동 수집 갱신 권장 · 9월 2일
현재 선택: 3개 · 임상 갱신 필요 3개
프로그램 상세에서 관심 등록 후 2개 이상 모으면 여기서 한 번에 비교할 수 있습니다.
표가 넓으면 좌우로 스크롤하세요. 핵심 비교 모드에서는 중요 항목만 표시됩니다.
| 항목 | |||
|---|---|---|---|
Overview Program | Stelara (ustekinumab) | Cosentyx (secukinumab) | Skyrizi (risankizumab-rzaa) |
Overview Company | Johnson & Johnson | Novartis | AbbVie |
Overview Modality | ANTIBODY | ANTIBODY | ANTIBODY |
Overview Target | IL-12 / IL-23 (p40) | IL-17A | IL-23 p19 |
Overview Indication | Psoriasis, psoriatic arthritis, Crohn's disease, ulcerative colitis | Psoriasis, PsA, AS, nr-axSpA, HS | Plaque psoriasis, PsA, Crohn's disease, ulcerative colitis |
Overview Phase | APPROVED | APPROVED | APPROVED |
Overview Status | APPROVED | APPROVED | APPROVED |
Overview Content status | Curated Core | Curated Core | Curated Core |
Overview Data Confidence | Editorial scope · Curated Core | Editorial scope · Curated Core | Editorial scope · Curated Core |
Overview Development Signal | Development Signal · Established | Development Signal · Established | Development Signal · Established |
Overview Approval status | FDA approved | FDA approved | FDA approved |
Positioning Key differentiator | Novel therapeutic avenues, including TYK2 and HDAC inhibitors, as well as nanotechnology-based delivery systems, show encoura | Novel approaches, including tolerogenic DC therapy and neuroimmune modulation, hold promise for refining treatment and addres | Novel therapeutic avenues, including TYK2 and HDAC inhibitors, as well as nanotechnology-based delivery systems, show encoura |
Positioning Known limitation | IL-23 axis escape, anti-drug antibodies, and non-IL-12/23 inflammation. | bypassed its classic signal adaptor and directly interacted with the calcium-binding protein S100A9 | IL-17 independent disease and immunogenicity. |
MoA Mechanism | Ustekinumab binds the p40 subunit shared by IL-12 and IL-23, preventing their interaction with IL-12Rβ1 receptor and downstream Th1/Th17 differentiation and cytokine production. | Secukinumab binds IL-17A and prevents interaction with IL-17RA/RC receptor complex, inhibiting keratinocyte and synovial inflammation driven by Th17 pathway. | Risankizumab selectively binds IL-23 p19 subunit, blocking IL-23 interaction with IL-23R and downstream Th17 pathway (IL-17A/F, IL-22). |
MoA Biomarker | biomarkers but require external validation in independent cohorts | PASI, ASAS response, radiographic progression in SpA. | PASI, sPGA, IBD endoscopic scores. |
Toxicology Species | Cynomolgus monkey, Mouse | Mouse | Cynomolgus monkey |
Toxicology Major finding | Infections, reversible posterior leukoencephalopathy syndrome (rare), hypersensitivity. | Nasopharyngitis, candidiasis (mucocutaneous), neutropenia; IBD caution in label. | Upper respiratory infections, headache, fatigue; low TB reactivation vs TNF class. |
Toxicology CRS | N/A | N/A | N/A |
Clinical Safety signal | Infections, reversible posterior leukoencephalopathy syndrome (rare), hypersensitivity. | Nasopharyngitis, candidiasis (mucocutaneous), neutropenia; IBD caution in label. | Upper respiratory infections, headache, fatigue; low TB reactivation vs TNF class. |
Clinical Program phase | APPROVED | APPROVED | APPROVED |
Clinical Trial activity | No active/completed counts | No active/completed counts | No active/completed counts |
타깃 · 모달리티 · 임상 근거 · 비임상 맥락으로 최대 5개 프로그램을 나란히 비교합니다. · 자동 수집 갱신 권장 · 9월 2일
현재 선택: 3개 · 임상 갱신 필요 3개
프로그램 상세에서 관심 등록 후 2개 이상 모으면 여기서 한 번에 비교할 수 있습니다.
표가 넓으면 좌우로 스크롤하세요. 핵심 비교 모드에서는 중요 항목만 표시됩니다.
| 항목 | |||
|---|---|---|---|
Overview Program | Stelara (ustekinumab) | Cosentyx (secukinumab) | Skyrizi (risankizumab-rzaa) |
Overview Company | Johnson & Johnson | Novartis | AbbVie |
Overview Modality | ANTIBODY | ANTIBODY | ANTIBODY |
Overview Target | IL-12 / IL-23 (p40) | IL-17A | IL-23 p19 |
Overview Indication | Psoriasis, psoriatic arthritis, Crohn's disease, ulcerative colitis | Psoriasis, PsA, AS, nr-axSpA, HS | Plaque psoriasis, PsA, Crohn's disease, ulcerative colitis |
Overview Phase | APPROVED | APPROVED | APPROVED |
Overview Status | APPROVED | APPROVED | APPROVED |
Overview Content status | Curated Core | Curated Core | Curated Core |
Overview Data Confidence | Editorial scope · Curated Core | Editorial scope · Curated Core | Editorial scope · Curated Core |
Overview Development Signal | Development Signal · Established | Development Signal · Established | Development Signal · Established |
Overview Approval status | FDA approved | FDA approved | FDA approved |
Positioning Key differentiator | Novel therapeutic avenues, including TYK2 and HDAC inhibitors, as well as nanotechnology-based delivery systems, show encoura | Novel approaches, including tolerogenic DC therapy and neuroimmune modulation, hold promise for refining treatment and addres | Novel therapeutic avenues, including TYK2 and HDAC inhibitors, as well as nanotechnology-based delivery systems, show encoura |
Positioning Known limitation | IL-23 axis escape, anti-drug antibodies, and non-IL-12/23 inflammation. | bypassed its classic signal adaptor and directly interacted with the calcium-binding protein S100A9 | IL-17 independent disease and immunogenicity. |
MoA Mechanism | Ustekinumab binds the p40 subunit shared by IL-12 and IL-23, preventing their interaction with IL-12Rβ1 receptor and downstream Th1/Th17 differentiation and cytokine production. | Secukinumab binds IL-17A and prevents interaction with IL-17RA/RC receptor complex, inhibiting keratinocyte and synovial inflammation driven by Th17 pathway. | Risankizumab selectively binds IL-23 p19 subunit, blocking IL-23 interaction with IL-23R and downstream Th17 pathway (IL-17A/F, IL-22). |
MoA Biomarker | biomarkers but require external validation in independent cohorts | PASI, ASAS response, radiographic progression in SpA. | PASI, sPGA, IBD endoscopic scores. |
Toxicology Species | Cynomolgus monkey, Mouse | Mouse | Cynomolgus monkey |
Toxicology Major finding | Infections, reversible posterior leukoencephalopathy syndrome (rare), hypersensitivity. | Nasopharyngitis, candidiasis (mucocutaneous), neutropenia; IBD caution in label. | Upper respiratory infections, headache, fatigue; low TB reactivation vs TNF class. |
Toxicology CRS | N/A | N/A | N/A |
Clinical Safety signal | Infections, reversible posterior leukoencephalopathy syndrome (rare), hypersensitivity. | Nasopharyngitis, candidiasis (mucocutaneous), neutropenia; IBD caution in label. | Upper respiratory infections, headache, fatigue; low TB reactivation vs TNF class. |
Clinical Program phase | APPROVED | APPROVED | APPROVED |
Clinical Trial activity | No active/completed counts | No active/completed counts | No active/completed counts |
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