구조모아 (StructureMoa)항암 chemical structure spider web
방문프로그램 상세에서 관심 등록 후 2개 이상 모으면 여기서 한 번에 비교할 수 있습니다.
표가 넓으면 좌우로 스크롤하세요. 핵심 비교 모드에서는 중요 항목만 표시됩니다.
| 항목 | enfortumab vedotin (Padcev, ASG-22ME, enfortumab-vedotin-ejfv) Astellas / Pfizer (Seagen)·Nectin-4 201 trials·t½ ADC ~3.4 days; free MMAE ~2.4 days | sacituzumab govitecan (Trodelvy, IMMU-132, sacituzumab-govitecan-hziy) Gilead / Immunomedics·TROP2 242 trials·t½ ADC ~16 h; free SN-38 ~18 h |
|---|---|---|
Overview Program | Padcev (enfortumab vedotin) | Trodelvy (sacituzumab govitecan) |
Overview Company | Astellas / Pfizer (Seagen) | Gilead / Immunomedics |
Overview Modality | ADC | ADC |
Overview Target | Nectin-4 | TROP2 |
Overview Indication | Locally advanced or metastatic urothelial carcinoma | Metastatic triple-negative breast cancer, pretreated HR+/HER2− breast cancer |
Overview Phase | APPROVED | APPROVED |
Overview Status | APPROVED | APPROVED |
Overview Content status | Curated Core | Curated Core |
Overview Data Confidence | Data Confidence · High | Data Confidence · High |
Overview Development Signal | Development Signal · Established | Development Signal · Established |
Overview Approval status | FDA approved | FDA approved |
Positioning Key differentiator | Nectin-4 is near-uniformly expressed in urothelial carcinoma, giving an unusually clean tumor-selective target in that tissue. | Very high DAR plus a deliberately unstable linker — extracellular SN-38 release gives bystander killing in TROP2-heterogeneous tumors. |
Positioning Known limitation | Nectin-4 loss, MMAE efflux, and tubulin alterations. | TROP2 downregulation, TOP1 mutation, and ABC-transporter payload efflux. |
Positioning Development positioning | 1L standard of care in urothelial carcinoma with pembrolizumab. | TROP2 class leader by approval history; now facing Datroway and other TROP2 ADCs. |
Technology Payload | MMAE (monomethyl auristatin E, tubulin inhibitor) | SN-38 (topoisomerase I inhibitor) |
Technology Linker | Protease-cleavable mc-vc-PAB, DAR ~3.8 | Hydrolyzable CL2A, DAR ~7.6 |
Technology DAR | DAR 3.8 | DAR 7.6 |
MoA Mechanism | Binds Nectin-4 on urothelial tumor cells, internalizes, and releases MMAE after cathepsin B cleavage; microtubule disruption arrests mitosis and triggers apoptosis. | Anti-TROP2 antibody binds and internalizes; the hydrolyzable linker releases SN-38 both intracellularly and in the tumor microenvironment, inhibiting topoisomerase I and causing lethal DNA double-strand breaks. |
MoA Biomarker | Nectin-4 expression is high in urothelial carcinoma; no companion diagnostic required. | TROP2 is broadly expressed in epithelial tumors; no companion diagnostic is required in the label. |
PK/PD Half-life | ADC ~3.4 days; free MMAE ~2.4 days | ADC ~16 h; free SN-38 ~18 h |
PK/PD Species | Cynomolgus monkey, ORR, PFS, OS | Mouse, ORR and PFS, ctDNA dynamics exploratory |
PK/PD Animal (cat.) | Human, NHP, In vitro | Human, Mouse, In vitro |
PK/PD Experiment | Pharmacokinetic | pd |
Toxicology Species | Cynomolgus monkey, Mouse, Rat | Cynomolgus monkey, Mouse, Hamster |
Toxicology Major finding | Boxed warning for serious skin reactions including SJS/TEN. Hyperglycemia, peripheral neuropathy, ocular surface toxicity, and pneumonitis also require monitoring. | Boxed warning for severe neutropenia and severe diarrhea. Nausea, alopecia, fatigue, and rare hypersensitivity are common. |
Toxicology CRS | N/A | N/A |
Clinical Safety signal | Boxed warning for serious skin reactions including SJS/TEN. Hyperglycemia, peripheral neuropathy, ocular surface toxicity, and pneumonitis also require monitoring. | Boxed warning for severe neutropenia and severe diarrhea. Nausea, alopecia, fatigue, and rare hypersensitivity are common. |
Clinical Selected reported efficacy | ORR 67.7% | ORR 44% |
Clinical Reported ORR | 67.7% (EV + pembrolizumab) | 44.0% |
Clinical Reported PFS | 12.5 mo vs 6.3 mo (chemo) | — |
Clinical Reported OS | 31.5 mo vs 16.1 mo (chemo) | — |
Clinical Result source | EV-302 / KEYNOTE-A39 (NCT04223856) | ClinicalTrials.gov NCT04916002 |
Clinical Program phase | APPROVED | APPROVED |
Clinical Trial activity | No active/completed counts | No active/completed counts |
Clinical Trial ref | NCT04223856 | NCT04916002 |
Preclinical Animal (cat.) | Human, Mouse, In vitro | Mouse |
프로그램 상세에서 관심 등록 후 2개 이상 모으면 여기서 한 번에 비교할 수 있습니다.
표가 넓으면 좌우로 스크롤하세요. 핵심 비교 모드에서는 중요 항목만 표시됩니다.
| 항목 | enfortumab vedotin (Padcev, ASG-22ME, enfortumab-vedotin-ejfv) Astellas / Pfizer (Seagen)·Nectin-4 201 trials·t½ ADC ~3.4 days; free MMAE ~2.4 days | sacituzumab govitecan (Trodelvy, IMMU-132, sacituzumab-govitecan-hziy) Gilead / Immunomedics·TROP2 242 trials·t½ ADC ~16 h; free SN-38 ~18 h |
|---|---|---|
Overview Program | Padcev (enfortumab vedotin) | Trodelvy (sacituzumab govitecan) |
Overview Company | Astellas / Pfizer (Seagen) | Gilead / Immunomedics |
Overview Modality | ADC | ADC |
Overview Target | Nectin-4 | TROP2 |
Overview Indication | Locally advanced or metastatic urothelial carcinoma | Metastatic triple-negative breast cancer, pretreated HR+/HER2− breast cancer |
Overview Phase | APPROVED | APPROVED |
Overview Status | APPROVED | APPROVED |
Overview Content status | Curated Core | Curated Core |
Overview Data Confidence | Data Confidence · High | Data Confidence · High |
Overview Development Signal | Development Signal · Established | Development Signal · Established |
Overview Approval status | FDA approved | FDA approved |
Positioning Key differentiator | Nectin-4 is near-uniformly expressed in urothelial carcinoma, giving an unusually clean tumor-selective target in that tissue. | Very high DAR plus a deliberately unstable linker — extracellular SN-38 release gives bystander killing in TROP2-heterogeneous tumors. |
Positioning Known limitation | Nectin-4 loss, MMAE efflux, and tubulin alterations. | TROP2 downregulation, TOP1 mutation, and ABC-transporter payload efflux. |
Positioning Development positioning | 1L standard of care in urothelial carcinoma with pembrolizumab. | TROP2 class leader by approval history; now facing Datroway and other TROP2 ADCs. |
Technology Payload | MMAE (monomethyl auristatin E, tubulin inhibitor) | SN-38 (topoisomerase I inhibitor) |
Technology Linker | Protease-cleavable mc-vc-PAB, DAR ~3.8 | Hydrolyzable CL2A, DAR ~7.6 |
Technology DAR | DAR 3.8 | DAR 7.6 |
MoA Mechanism | Binds Nectin-4 on urothelial tumor cells, internalizes, and releases MMAE after cathepsin B cleavage; microtubule disruption arrests mitosis and triggers apoptosis. | Anti-TROP2 antibody binds and internalizes; the hydrolyzable linker releases SN-38 both intracellularly and in the tumor microenvironment, inhibiting topoisomerase I and causing lethal DNA double-strand breaks. |
MoA Biomarker | Nectin-4 expression is high in urothelial carcinoma; no companion diagnostic required. | TROP2 is broadly expressed in epithelial tumors; no companion diagnostic is required in the label. |
PK/PD Half-life | ADC ~3.4 days; free MMAE ~2.4 days | ADC ~16 h; free SN-38 ~18 h |
PK/PD Species | Cynomolgus monkey, ORR, PFS, OS | Mouse, ORR and PFS, ctDNA dynamics exploratory |
PK/PD Animal (cat.) | Human, NHP, In vitro | Human, Mouse, In vitro |
PK/PD Experiment | Pharmacokinetic | pd |
Toxicology Species | Cynomolgus monkey, Mouse, Rat | Cynomolgus monkey, Mouse, Hamster |
Toxicology Major finding | Boxed warning for serious skin reactions including SJS/TEN. Hyperglycemia, peripheral neuropathy, ocular surface toxicity, and pneumonitis also require monitoring. | Boxed warning for severe neutropenia and severe diarrhea. Nausea, alopecia, fatigue, and rare hypersensitivity are common. |
Toxicology CRS | N/A | N/A |
Clinical Safety signal | Boxed warning for serious skin reactions including SJS/TEN. Hyperglycemia, peripheral neuropathy, ocular surface toxicity, and pneumonitis also require monitoring. | Boxed warning for severe neutropenia and severe diarrhea. Nausea, alopecia, fatigue, and rare hypersensitivity are common. |
Clinical Selected reported efficacy | ORR 67.7% | ORR 44% |
Clinical Reported ORR | 67.7% (EV + pembrolizumab) | 44.0% |
Clinical Reported PFS | 12.5 mo vs 6.3 mo (chemo) | — |
Clinical Reported OS | 31.5 mo vs 16.1 mo (chemo) | — |
Clinical Result source | EV-302 / KEYNOTE-A39 (NCT04223856) | ClinicalTrials.gov NCT04916002 |
Clinical Program phase | APPROVED | APPROVED |
Clinical Trial activity | No active/completed counts | No active/completed counts |
Clinical Trial ref | NCT04223856 | NCT04916002 |
Preclinical Animal (cat.) | Human, Mouse, In vitro | Mouse |
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