구조모아 (StructureMoa)항암 chemical structure spider web
방문타깃 · 모달리티 · 임상 근거 · 비임상 맥락으로 최대 5개 프로그램을 나란히 비교합니다. · 다음 갱신 D-6 · 마지막 9월 2일
현재 선택: 5개 · 임상 갱신 필요 1개 · Data Tier에서 열림
프로그램 상세에서 관심 등록 후 2개 이상 모으면 여기서 한 번에 비교할 수 있습니다.
표가 넓으면 좌우로 스크롤하세요. 핵심 비교 모드에서는 중요 항목만 표시됩니다.
| 항목 | zanidatamab (Ziihera, ZW25, zanidatamab-hrii) Jazz Pharmaceuticals / Zymeworks·HER2 (biparatopic) 35 trials·t½ ~7 days | tislelizumab (Tevimbra, BGB-A317, tislelizumab-jsgr) BeOne Medicines·PD-1 213 trials·t½ ~20 days class range | zolbetuximab (Vyloy, IMAB362, zolbetuximab-clzb, claudiximab) Astellas·CLDN18.2 (claudin-18.2) 26 trials·t½ ~11 days | ||
|---|---|---|---|---|---|
Overview Program | Herceptin (trastuzumab) | Ziihera (zanidatamab) | Tevimbra (tislelizumab) | Vyloy (zolbetuximab) | Obinutuzumab |
Overview Company | Roche / Genentech | Jazz Pharmaceuticals / Zymeworks | BeOne Medicines | Astellas | Roche / Genentech |
Overview Modality | ANTIBODY | ANTIBODY | ANTIBODY | ANTIBODY | ANTIBODY |
Overview Target | HER2 | HER2 (biparatopic) | PD-1 | CLDN18.2 (claudin-18.2) | B-cell Lymphoma |
Overview Indication | HER2+ breast cancer, HER2+ gastric/GEJ adenocarcinoma | First-line HER2-positive gastric, GEJ, or esophageal adenocarcinoma; previously treated HER2-positive biliary tract cancer | Esophageal squamous cell carcinoma, gastric/GEJ adenocarcinoma, and first-line HER2-positive GEA with zanidatamab and chemotherapy | CLDN18.2-positive HER2-negative advanced gastric or gastroesophageal junction adenocarcinoma | Breast Adenocarcinoma; Metastatic Breast Carcinoma |
Overview Phase | APPROVED | APPROVED | APPROVED | APPROVED | PHASE_3 |
Overview Status | APPROVED | APPROVED | APPROVED | APPROVED | RECRUITING |
Overview Content status | Curated Core | Curated Core | Curated Core | Curated Core | Curated Core |
Overview Data Confidence | Data Confidence · High | Data Confidence · High | Data Confidence · High | Data Confidence · High | Data Confidence · High |
Overview Development Signal | Development Signal · Established | Development Signal · Established | Development Signal · Established | Development Signal · Established | Development Signal · Emerging |
Overview Approval status | FDA approved | FDA approved | FDA approved | FDA approved | Investigational |
Positioning Key differentiator | novel bifunctional chelator (2E-C-NETA) for applications in 177 Lu-based TRT | Dual-epitope binding drives receptor clustering, faster internalization, and stronger signaling blockade than either monoclonal alone. In GEA the label splits IHC 3+ (chemo doublet) from IHC 3+ or 2+/ISH+ (chemo + Tevimbra). | Not a Keytruda substitute. The 2026 GEA label is a HER2-selected triplet with zanidatamab, not a PD-L1-unselected 1L PD-1 row. | Exploits a tight-junction protein that only becomes accessible after malignant transformation, creating tumor selectivity without a novel modality. | novel calcineurin inhibitor with predictable pharmacokinetics, increases complete renal response rates and rapidly reduces pr |
Positioning Known limitation | resistance to trastuzumab-based targeted therapy and limited intratumoral antibody penetration continue to restrict clinical outcomes | HER2 heterogeneity, PI3K pathway activation, and bypass RTK signaling. | Antigen-presentation loss, alternate checkpoints, immunosuppressive TME. | CLDN18.2 heterogeneity and loss under treatment pressure. | resistance to treatment |
Positioning Development positioning | — | Challenges the ToGA trastuzumab-chemo backbone in 1L HER2+ GEA; still the only HER2 agent with a dedicated BTC indication. | BeOne PD-1 with a China-heavy development history; the US HER2+ GEA triplet is the catalog reason to keep it next to Ziihera, not next to Keytruda's pan-tumor row. | Only approved CLDN18.2 agent; CAR-T and ADC competitors are still in trials. | — |
MoA Mechanism | Trastuzumab binds domain IV of HER2, inhibiting ligand-independent HER2 signaling, mediating ADCC via Fcγ receptors, and inducing internalization/degradation of HER2. | Simultaneous binding of two non-overlapping HER2 epitopes crosslinks adjacent receptors, causing receptor clustering, internalization, and degradation alongside ADCC and complement activity. | Binds PD-1 on T cells, blocking PD-L1/PD-L2 engagement and restoring antitumor T-cell activity. Fc silencing is intended to avoid macrophage-mediated T-cell clearance. | Binds CLDN18.2 on gastric tumor cells and kills them through antibody-dependent cellular cytotoxicity and complement-dependent cytotoxicity. | targets type I interferon signaling |
MoA Biomarker | HER2 IHC 3+ or ISH amplified (ASCO/CAP guidelines). | GEA: PATHWAY 4B5 IHC and VENTANA Dual ISH. IHC 3+ for chemo doublet; IHC 3+ or IHC 2+/ISH+ when Tevimbra is added. BTC: HER2 IHC 3+. | PD-L1 and tumor type on older labels; HER2 IHC/ISH when given with Ziihera. | CLDN18.2 IHC with ≥75% of tumor cells at moderate-to-strong membranous staining. | biomarker to guide treatment duration in two prospective trials of venetoclax- and sonrotoclax-based triplets |
PK/PD Half-life | 4 h | ~7 days | ~20 days class range | ~11 days | — |
PK/PD Species | Mouse, OS in metastatic BC | Cynomolgus monkey, Human, OS and PFS in GEA, ORR and DOR in BTC | OS/PFS, radiographic response | — | Cynomolgus monkey, Macaque, Mouse |
PK/PD Animal (cat.) | Mouse, In vitro | Human, NHP, In vitro | Human | Human, In vitro | Mouse, NHP, Monkey |
PK/PD Experiment | Pharmacokinetic | pd | — | pharmacokinetic | Pharmacodynamic |
Toxicology Species | Mouse, Rat | Human | — | Mouse | Cynomolgus monkey, Macaque, Mouse |
Toxicology Animal (cat.) | — | — | — | — | Mouse, NHP, Monkey |
Toxicology Major finding | Cardiotoxicity (LVEF decline, CHF risk especially with anthracyclines); infusion reactions; myelosuppression in combos. | Embryo-fetal toxicity warning. Diarrhea, infusion-related reactions, and left ventricular dysfunction require monitoring, as with the HER2 antibody class. | Immune-mediated pneumonitis, colitis, hepatitis, endocrinopathies, and infusion-related reactions. Allogeneic transplant complications are labeled. | Nausea and vomiting are frequent and often infusion-related, requiring rate adjustment and antiemetics. Hypoalbuminemia, appetite loss, and hypersensitivity also occur. | thrombocytopenia or organ dysfunction, were documented |
Toxicology CRS | N/A | N/A | N/A | N/A | Reported |
Clinical Safety signal | Cardiotoxicity (LVEF decline, CHF risk especially with anthracyclines); infusion reactions; myelosuppression in combos. | Embryo-fetal toxicity warning. Diarrhea, infusion-related reactions, and left ventricular dysfunction require monitoring, as with the HER2 antibody class. | Immune-mediated pneumonitis, colitis, hepatitis, endocrinopathies, and infusion-related reactions. Allogeneic transplant complications are labeled. | Nausea and vomiting are frequent and often infusion-related, requiring rate adjustment and antiemetics. Hypoalbuminemia, appetite loss, and hypersensitivity also occur. | thrombocytopenia or organ dysfunction, were documented |
Clinical Selected reported efficacy | ORR 91.2% | ORR 52% | ORR 87.1% | 48.1% | ORR 100% |
Clinical Reported ORR | 91.2% | 52% | 87.1% | — | 100.0% |
Clinical Reported PFS | — | ~5.5 mo | 31.5 | — | — |
Clinical Reported OS | — | 15.54 | — | — | — |
Clinical Result source | ClinicalTrials.gov NCT02149524 | HERIZON-BTC-01 (NCT04466891) | ClinicalTrials.gov NCT03209973 | SPOTLIGHT (NCT03504397) / GLOW (NCT03653507) | ClinicalTrials.gov NCT02611323 |
Clinical Program phase | APPROVED | APPROVED | APPROVED | APPROVED | PHASE_3 |
Clinical Trial activity | No active/completed counts | No active/completed counts | — | No active/completed counts | No active/completed counts |
Clinical Trial ref | NCT02149524 | NCT04466891 | NCT03209973 | NCT03504397 | NCT02611323 |
Preclinical Animal (cat.) | — | Unknown | — | Mouse, In vitro | — |
타깃 · 모달리티 · 임상 근거 · 비임상 맥락으로 최대 5개 프로그램을 나란히 비교합니다. · 다음 갱신 D-6 · 마지막 9월 2일
현재 선택: 5개 · 임상 갱신 필요 1개 · Data Tier에서 열림
프로그램 상세에서 관심 등록 후 2개 이상 모으면 여기서 한 번에 비교할 수 있습니다.
표가 넓으면 좌우로 스크롤하세요. 핵심 비교 모드에서는 중요 항목만 표시됩니다.
| 항목 | zanidatamab (Ziihera, ZW25, zanidatamab-hrii) Jazz Pharmaceuticals / Zymeworks·HER2 (biparatopic) 35 trials·t½ ~7 days | tislelizumab (Tevimbra, BGB-A317, tislelizumab-jsgr) BeOne Medicines·PD-1 213 trials·t½ ~20 days class range | zolbetuximab (Vyloy, IMAB362, zolbetuximab-clzb, claudiximab) Astellas·CLDN18.2 (claudin-18.2) 26 trials·t½ ~11 days | ||
|---|---|---|---|---|---|
Overview Program | Herceptin (trastuzumab) | Ziihera (zanidatamab) | Tevimbra (tislelizumab) | Vyloy (zolbetuximab) | Obinutuzumab |
Overview Company | Roche / Genentech | Jazz Pharmaceuticals / Zymeworks | BeOne Medicines | Astellas | Roche / Genentech |
Overview Modality | ANTIBODY | ANTIBODY | ANTIBODY | ANTIBODY | ANTIBODY |
Overview Target | HER2 | HER2 (biparatopic) | PD-1 | CLDN18.2 (claudin-18.2) | B-cell Lymphoma |
Overview Indication | HER2+ breast cancer, HER2+ gastric/GEJ adenocarcinoma | First-line HER2-positive gastric, GEJ, or esophageal adenocarcinoma; previously treated HER2-positive biliary tract cancer | Esophageal squamous cell carcinoma, gastric/GEJ adenocarcinoma, and first-line HER2-positive GEA with zanidatamab and chemotherapy | CLDN18.2-positive HER2-negative advanced gastric or gastroesophageal junction adenocarcinoma | Breast Adenocarcinoma; Metastatic Breast Carcinoma |
Overview Phase | APPROVED | APPROVED | APPROVED | APPROVED | PHASE_3 |
Overview Status | APPROVED | APPROVED | APPROVED | APPROVED | RECRUITING |
Overview Content status | Curated Core | Curated Core | Curated Core | Curated Core | Curated Core |
Overview Data Confidence | Data Confidence · High | Data Confidence · High | Data Confidence · High | Data Confidence · High | Data Confidence · High |
Overview Development Signal | Development Signal · Established | Development Signal · Established | Development Signal · Established | Development Signal · Established | Development Signal · Emerging |
Overview Approval status | FDA approved | FDA approved | FDA approved | FDA approved | Investigational |
Positioning Key differentiator | novel bifunctional chelator (2E-C-NETA) for applications in 177 Lu-based TRT | Dual-epitope binding drives receptor clustering, faster internalization, and stronger signaling blockade than either monoclonal alone. In GEA the label splits IHC 3+ (chemo doublet) from IHC 3+ or 2+/ISH+ (chemo + Tevimbra). | Not a Keytruda substitute. The 2026 GEA label is a HER2-selected triplet with zanidatamab, not a PD-L1-unselected 1L PD-1 row. | Exploits a tight-junction protein that only becomes accessible after malignant transformation, creating tumor selectivity without a novel modality. | novel calcineurin inhibitor with predictable pharmacokinetics, increases complete renal response rates and rapidly reduces pr |
Positioning Known limitation | resistance to trastuzumab-based targeted therapy and limited intratumoral antibody penetration continue to restrict clinical outcomes | HER2 heterogeneity, PI3K pathway activation, and bypass RTK signaling. | Antigen-presentation loss, alternate checkpoints, immunosuppressive TME. | CLDN18.2 heterogeneity and loss under treatment pressure. | resistance to treatment |
Positioning Development positioning | — | Challenges the ToGA trastuzumab-chemo backbone in 1L HER2+ GEA; still the only HER2 agent with a dedicated BTC indication. | BeOne PD-1 with a China-heavy development history; the US HER2+ GEA triplet is the catalog reason to keep it next to Ziihera, not next to Keytruda's pan-tumor row. | Only approved CLDN18.2 agent; CAR-T and ADC competitors are still in trials. | — |
MoA Mechanism | Trastuzumab binds domain IV of HER2, inhibiting ligand-independent HER2 signaling, mediating ADCC via Fcγ receptors, and inducing internalization/degradation of HER2. | Simultaneous binding of two non-overlapping HER2 epitopes crosslinks adjacent receptors, causing receptor clustering, internalization, and degradation alongside ADCC and complement activity. | Binds PD-1 on T cells, blocking PD-L1/PD-L2 engagement and restoring antitumor T-cell activity. Fc silencing is intended to avoid macrophage-mediated T-cell clearance. | Binds CLDN18.2 on gastric tumor cells and kills them through antibody-dependent cellular cytotoxicity and complement-dependent cytotoxicity. | targets type I interferon signaling |
MoA Biomarker | HER2 IHC 3+ or ISH amplified (ASCO/CAP guidelines). | GEA: PATHWAY 4B5 IHC and VENTANA Dual ISH. IHC 3+ for chemo doublet; IHC 3+ or IHC 2+/ISH+ when Tevimbra is added. BTC: HER2 IHC 3+. | PD-L1 and tumor type on older labels; HER2 IHC/ISH when given with Ziihera. | CLDN18.2 IHC with ≥75% of tumor cells at moderate-to-strong membranous staining. | biomarker to guide treatment duration in two prospective trials of venetoclax- and sonrotoclax-based triplets |
PK/PD Half-life | 4 h | ~7 days | ~20 days class range | ~11 days | — |
PK/PD Species | Mouse, OS in metastatic BC | Cynomolgus monkey, Human, OS and PFS in GEA, ORR and DOR in BTC | OS/PFS, radiographic response | — | Cynomolgus monkey, Macaque, Mouse |
PK/PD Animal (cat.) | Mouse, In vitro | Human, NHP, In vitro | Human | Human, In vitro | Mouse, NHP, Monkey |
PK/PD Experiment | Pharmacokinetic | pd | — | pharmacokinetic | Pharmacodynamic |
Toxicology Species | Mouse, Rat | Human | — | Mouse | Cynomolgus monkey, Macaque, Mouse |
Toxicology Animal (cat.) | — | — | — | — | Mouse, NHP, Monkey |
Toxicology Major finding | Cardiotoxicity (LVEF decline, CHF risk especially with anthracyclines); infusion reactions; myelosuppression in combos. | Embryo-fetal toxicity warning. Diarrhea, infusion-related reactions, and left ventricular dysfunction require monitoring, as with the HER2 antibody class. | Immune-mediated pneumonitis, colitis, hepatitis, endocrinopathies, and infusion-related reactions. Allogeneic transplant complications are labeled. | Nausea and vomiting are frequent and often infusion-related, requiring rate adjustment and antiemetics. Hypoalbuminemia, appetite loss, and hypersensitivity also occur. | thrombocytopenia or organ dysfunction, were documented |
Toxicology CRS | N/A | N/A | N/A | N/A | Reported |
Clinical Safety signal | Cardiotoxicity (LVEF decline, CHF risk especially with anthracyclines); infusion reactions; myelosuppression in combos. | Embryo-fetal toxicity warning. Diarrhea, infusion-related reactions, and left ventricular dysfunction require monitoring, as with the HER2 antibody class. | Immune-mediated pneumonitis, colitis, hepatitis, endocrinopathies, and infusion-related reactions. Allogeneic transplant complications are labeled. | Nausea and vomiting are frequent and often infusion-related, requiring rate adjustment and antiemetics. Hypoalbuminemia, appetite loss, and hypersensitivity also occur. | thrombocytopenia or organ dysfunction, were documented |
Clinical Selected reported efficacy | ORR 91.2% | ORR 52% | ORR 87.1% | 48.1% | ORR 100% |
Clinical Reported ORR | 91.2% | 52% | 87.1% | — | 100.0% |
Clinical Reported PFS | — | ~5.5 mo | 31.5 | — | — |
Clinical Reported OS | — | 15.54 | — | — | — |
Clinical Result source | ClinicalTrials.gov NCT02149524 | HERIZON-BTC-01 (NCT04466891) | ClinicalTrials.gov NCT03209973 | SPOTLIGHT (NCT03504397) / GLOW (NCT03653507) | ClinicalTrials.gov NCT02611323 |
Clinical Program phase | APPROVED | APPROVED | APPROVED | APPROVED | PHASE_3 |
Clinical Trial activity | No active/completed counts | No active/completed counts | — | No active/completed counts | No active/completed counts |
Clinical Trial ref | NCT02149524 | NCT04466891 | NCT03209973 | NCT03504397 | NCT02611323 |
Preclinical Animal (cat.) | — | Unknown | — | Mouse, In vitro | — |
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