타깃 · 모달리티 · 임상 근거 · 비임상 맥락으로 최대 5개 프로그램을 나란히 비교합니다. · 자동 수집 갱신 권장 · 9월 2일
현재 선택: 1개 · 임상 갱신 필요 1개
프로그램 상세에서 관심 등록 후 2개 이상 모으면 여기서 한 번에 비교할 수 있습니다.
표가 넓으면 좌우로 스크롤하세요. 핵심 비교 모드에서는 중요 항목만 표시됩니다.
| 항목 | |
|---|---|
Overview Program | Ebglyss (lebrikizumab-lbkz) |
Overview Company | Eli Lilly |
Overview Modality | ANTIBODY |
Overview Target | IL-13 |
Overview Indication | Moderate-to-severe atopic dermatitis |
Overview Phase | APPROVED |
Overview Status | APPROVED |
Overview Content status | Curated Core |
Overview Data Confidence | Editorial scope · Curated Core |
Overview Development Signal | Development Signal · Established |
Overview Approval status | FDA approved |
Positioning Key differentiator | unique disposition of simvastatin rather than enzyme or transporter inhibition |
Positioning Known limitation | Concurrent IL-4 signaling and non-Type 2 dermatitis. |
MoA Mechanism | Lebrikizumab binds IL-13 with high affinity, blocking IL-13Rα1/IL-4Rα signaling and downstream Type 2 inflammation in skin (barrier dysfunction, pruritus, eosinophilia). |
MoA Biomarker | EASI, IGA 0/1, pruritus NRS. |
Toxicology Species | Cynomolgus monkey |
Toxicology Major finding | Conjunctivitis, nasopharyngitis, injection-site reactions; herpes zoster warnings per class. |
Toxicology CRS | N/A |
Clinical Safety signal | Conjunctivitis, nasopharyngitis, injection-site reactions; herpes zoster warnings per class. |
Clinical Program phase | APPROVED |
Clinical Trial activity | No active/completed counts |
타깃 · 모달리티 · 임상 근거 · 비임상 맥락으로 최대 5개 프로그램을 나란히 비교합니다. · 자동 수집 갱신 권장 · 9월 2일
현재 선택: 1개 · 임상 갱신 필요 1개
프로그램 상세에서 관심 등록 후 2개 이상 모으면 여기서 한 번에 비교할 수 있습니다.
표가 넓으면 좌우로 스크롤하세요. 핵심 비교 모드에서는 중요 항목만 표시됩니다.
| 항목 | |
|---|---|
Overview Program | Ebglyss (lebrikizumab-lbkz) |
Overview Company | Eli Lilly |
Overview Modality | ANTIBODY |
Overview Target | IL-13 |
Overview Indication | Moderate-to-severe atopic dermatitis |
Overview Phase | APPROVED |
Overview Status | APPROVED |
Overview Content status | Curated Core |
Overview Data Confidence | Editorial scope · Curated Core |
Overview Development Signal | Development Signal · Established |
Overview Approval status | FDA approved |
Positioning Key differentiator | unique disposition of simvastatin rather than enzyme or transporter inhibition |
Positioning Known limitation | Concurrent IL-4 signaling and non-Type 2 dermatitis. |
MoA Mechanism | Lebrikizumab binds IL-13 with high affinity, blocking IL-13Rα1/IL-4Rα signaling and downstream Type 2 inflammation in skin (barrier dysfunction, pruritus, eosinophilia). |
MoA Biomarker | EASI, IGA 0/1, pruritus NRS. |
Toxicology Species | Cynomolgus monkey |
Toxicology Major finding | Conjunctivitis, nasopharyngitis, injection-site reactions; herpes zoster warnings per class. |
Toxicology CRS | N/A |
Clinical Safety signal | Conjunctivitis, nasopharyngitis, injection-site reactions; herpes zoster warnings per class. |
Clinical Program phase | APPROVED |
Clinical Trial activity | No active/completed counts |
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