구조모아 (StructureMoa)항암 chemical structure spider web
방문타깃 · 모달리티 · 임상 근거 · 비임상 맥락으로 최대 5개 프로그램을 나란히 비교합니다. · 다음 갱신 D-5 · 마지막 9월 2일
현재 선택: 1개 · 임상 갱신 필요 1개
프로그램 상세에서 관심 등록 후 2개 이상 모으면 여기서 한 번에 비교할 수 있습니다.
표가 넓으면 좌우로 스크롤하세요. 핵심 비교 모드에서는 중요 항목만 표시됩니다.
| 항목 | BAT (Best Available Therapy, Best Available Therapy (BAT)) Incyte Corporation·Relapsing Multiple Sclerosis 240 trials·t½ 52 h |
|---|---|
Overview Program | Best Available Therapy (BAT) |
Overview Company | Incyte Corporation |
Overview Modality | ANTIBODY |
Overview Target | Relapsing Multiple Sclerosis |
Overview Indication | Chronic Graft-versus-host-disease |
Overview Phase | PHASE_3 |
Overview Status | RECRUITING |
Overview Content status | Limited Data |
Overview Data Confidence | Data Confidence · Low |
Overview Development Signal | Development Signal · Emerging |
Overview Approval status | Investigational |
MoA Mechanism | inhibits high-fat diet-induced obesity by regulating the ROS/JNK/BRD4/SHP2 signaling pathway |
MoA Biomarker | biomarker data support an endotype-driven approach: higher total immunoglobulin E (IgE) is generally associat |
PK/PD Half-life | 52 h |
PK/PD Species | Mouse |
PK/PD Animal (cat.) | Mouse |
PK/PD Experiment | PK |
Toxicology Species | Mouse |
Toxicology Animal (cat.) | Mouse |
Toxicology Major finding | Fat depot-specific accumulation of benzo(a)pyrene metabolites in rats fed with western diet and its implications for colon cancer.. Obesity is one of the factors that potentiate the development of colorectal cancer (CRC). Our previous studies using a rat model, the Polyposis In the Rat Colon (PIRC) kindred type revealed that compared to regular diet (RD), the Western diet (WD) accelerated the prog… |
Clinical Safety signal | Fat depot-specific accumulation of benzo(a)pyrene metabolites in rats fed with western diet and its implications for colon cancer.. Obesity is one of the factors that potentiate the development of colorectal cancer (CRC). Our previous studies using a rat model, the Polyposis In the Rat Colon (PIRC) kindred type revealed that compared to regular diet (RD), the Western diet (WD) accelerated the prog… |
Clinical Selected reported efficacy | 49.7% |
Clinical Result source | ClinicalTrials.gov NCT03112603 |
Clinical Program phase | PHASE_3 |
Clinical Trial activity | No active/completed counts |
Clinical Trial ref | NCT03112603 |
타깃 · 모달리티 · 임상 근거 · 비임상 맥락으로 최대 5개 프로그램을 나란히 비교합니다. · 다음 갱신 D-5 · 마지막 9월 2일
현재 선택: 1개 · 임상 갱신 필요 1개
프로그램 상세에서 관심 등록 후 2개 이상 모으면 여기서 한 번에 비교할 수 있습니다.
표가 넓으면 좌우로 스크롤하세요. 핵심 비교 모드에서는 중요 항목만 표시됩니다.
| 항목 | BAT (Best Available Therapy, Best Available Therapy (BAT)) Incyte Corporation·Relapsing Multiple Sclerosis 240 trials·t½ 52 h |
|---|---|
Overview Program | Best Available Therapy (BAT) |
Overview Company | Incyte Corporation |
Overview Modality | ANTIBODY |
Overview Target | Relapsing Multiple Sclerosis |
Overview Indication | Chronic Graft-versus-host-disease |
Overview Phase | PHASE_3 |
Overview Status | RECRUITING |
Overview Content status | Limited Data |
Overview Data Confidence | Data Confidence · Low |
Overview Development Signal | Development Signal · Emerging |
Overview Approval status | Investigational |
MoA Mechanism | inhibits high-fat diet-induced obesity by regulating the ROS/JNK/BRD4/SHP2 signaling pathway |
MoA Biomarker | biomarker data support an endotype-driven approach: higher total immunoglobulin E (IgE) is generally associat |
PK/PD Half-life | 52 h |
PK/PD Species | Mouse |
PK/PD Animal (cat.) | Mouse |
PK/PD Experiment | PK |
Toxicology Species | Mouse |
Toxicology Animal (cat.) | Mouse |
Toxicology Major finding | Fat depot-specific accumulation of benzo(a)pyrene metabolites in rats fed with western diet and its implications for colon cancer.. Obesity is one of the factors that potentiate the development of colorectal cancer (CRC). Our previous studies using a rat model, the Polyposis In the Rat Colon (PIRC) kindred type revealed that compared to regular diet (RD), the Western diet (WD) accelerated the prog… |
Clinical Safety signal | Fat depot-specific accumulation of benzo(a)pyrene metabolites in rats fed with western diet and its implications for colon cancer.. Obesity is one of the factors that potentiate the development of colorectal cancer (CRC). Our previous studies using a rat model, the Polyposis In the Rat Colon (PIRC) kindred type revealed that compared to regular diet (RD), the Western diet (WD) accelerated the prog… |
Clinical Selected reported efficacy | 49.7% |
Clinical Result source | ClinicalTrials.gov NCT03112603 |
Clinical Program phase | PHASE_3 |
Clinical Trial activity | No active/completed counts |
Clinical Trial ref | NCT03112603 |
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