구조모아 (StructureMoa)항암 chemical structure spider web
방문타깃 · 모달리티 · 임상 근거 · 비임상 맥락으로 최대 5개 프로그램을 나란히 비교합니다. · 다음 갱신 D-6 · 마지막 9월 2일
현재 선택: 1개 · 임상 갱신 필요 1개
프로그램 상세에서 관심 등록 후 2개 이상 모으면 여기서 한 번에 비교할 수 있습니다.
표가 넓으면 좌우로 스크롤하세요. 핵심 비교 모드에서는 중요 항목만 표시됩니다.
| 항목 | |
|---|---|
Overview Program | Belantamab mafodotin |
Overview Company | GSK |
Overview Modality | ADC |
Overview Target | Multiple Myeloma |
Overview Indication | Primary Immune Thrombocytopenia (ITP) |
Overview Phase | PHASE_3 |
Overview Status | RECRUITING |
Overview Content status | Standard Database |
Overview Data Confidence | Data Confidence · Medium |
Overview Development Signal | Development Signal · Emerging |
Overview Approval status | Investigational |
Technology Payload | cys-mcMMAF |
Technology Linker | linker, or payload that have limited their development |
MoA Mechanism | targeting specific cell surface antigens, many ADCs have also been associated with unique toxicities related to the antigen |
MoA Biomarker | biomarkers and biologic profiling to enable optimal, integrated use of mAbs, ADCs, CAR T-cell therapies, and |
PK/PD Half-life | 16.8 h |
PK/PD Species | Cynomolgus monkey |
PK/PD Animal (cat.) | NHP |
PK/PD Experiment | Pd |
Toxicology Species | Cynomolgus monkey |
Toxicology Animal (cat.) | NHP |
Toxicology Major finding | thrombocytopenia (DREAMM-1 and DREAMM -2) |
Toxicology CRS | Reported |
Clinical Safety signal | thrombocytopenia (DREAMM-1 and DREAMM -2) |
Clinical Selected reported efficacy | ORR 100% |
Clinical Reported ORR | 100% |
Clinical Result source | ClinicalTrials.gov NCT03828292 |
Clinical Program phase | PHASE_3 |
Clinical Trial activity | No active/completed counts |
Clinical Trial ref | NCT03828292 |
타깃 · 모달리티 · 임상 근거 · 비임상 맥락으로 최대 5개 프로그램을 나란히 비교합니다. · 다음 갱신 D-6 · 마지막 9월 2일
현재 선택: 1개 · 임상 갱신 필요 1개
프로그램 상세에서 관심 등록 후 2개 이상 모으면 여기서 한 번에 비교할 수 있습니다.
표가 넓으면 좌우로 스크롤하세요. 핵심 비교 모드에서는 중요 항목만 표시됩니다.
| 항목 | |
|---|---|
Overview Program | Belantamab mafodotin |
Overview Company | GSK |
Overview Modality | ADC |
Overview Target | Multiple Myeloma |
Overview Indication | Primary Immune Thrombocytopenia (ITP) |
Overview Phase | PHASE_3 |
Overview Status | RECRUITING |
Overview Content status | Standard Database |
Overview Data Confidence | Data Confidence · Medium |
Overview Development Signal | Development Signal · Emerging |
Overview Approval status | Investigational |
Technology Payload | cys-mcMMAF |
Technology Linker | linker, or payload that have limited their development |
MoA Mechanism | targeting specific cell surface antigens, many ADCs have also been associated with unique toxicities related to the antigen |
MoA Biomarker | biomarkers and biologic profiling to enable optimal, integrated use of mAbs, ADCs, CAR T-cell therapies, and |
PK/PD Half-life | 16.8 h |
PK/PD Species | Cynomolgus monkey |
PK/PD Animal (cat.) | NHP |
PK/PD Experiment | Pd |
Toxicology Species | Cynomolgus monkey |
Toxicology Animal (cat.) | NHP |
Toxicology Major finding | thrombocytopenia (DREAMM-1 and DREAMM -2) |
Toxicology CRS | Reported |
Clinical Safety signal | thrombocytopenia (DREAMM-1 and DREAMM -2) |
Clinical Selected reported efficacy | ORR 100% |
Clinical Reported ORR | 100% |
Clinical Result source | ClinicalTrials.gov NCT03828292 |
Clinical Program phase | PHASE_3 |
Clinical Trial activity | No active/completed counts |
Clinical Trial ref | NCT03828292 |
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