구조모아 (StructureMoa)항암 chemical structure spider web
방문타깃 · 모달리티 · 임상 근거 · 비임상 맥락으로 최대 5개 프로그램을 나란히 비교합니다. · 다음 갱신 D-6 · 마지막 9월 2일
현재 선택: 1개 · 임상 갱신 필요 1개
프로그램 상세에서 관심 등록 후 2개 이상 모으면 여기서 한 번에 비교할 수 있습니다.
표가 넓으면 좌우로 스크롤하세요. 핵심 비교 모드에서는 중요 항목만 표시됩니다.
| 항목 | |
|---|---|
Overview Program | Antibody-Drug Conjugate Therapy |
Overview Company | Favrille |
Overview Modality | ADC |
Overview Target | FRα |
Overview Indication | Metastatic Bladder Urothelial Carcinoma; Metastatic Renal Pelvis and Ureter Urothelial Carcinoma |
Overview Phase | PHASE_2 |
Overview Status | RECRUITING |
Overview Content status | Standard Database |
Overview Data Confidence | Data Confidence · Medium |
Overview Development Signal | Development Signal · Emerging |
Overview Approval status | Investigational |
Technology Payload | deruxtecan for metastatic breast cancer |
Technology Linker | linker stability influence ocular toxicity |
MoA Mechanism | ADC, while the AKR1C1-WWP2 axis promotes extracellular vesicle-mediated ADC export and clearance, thereby reducing intracellular payload accumulation |
MoA Biomarker | HER2-positive |
PK/PD Half-life | 7 h |
PK/PD Species | Mouse, Human |
PK/PD Animal (cat.) | Human, Mouse, In vitro |
PK/PD Experiment | PD |
Toxicology Species | Mouse, Human |
Toxicology Animal (cat.) | Human, Mouse, In vitro |
Toxicology Major finding | interstitial lung disease (ILD) |
Toxicology CRS | Reported |
Clinical Safety signal | interstitial lung disease (ILD) |
Clinical Selected reported efficacy | ORR 86% |
Clinical Reported ORR | 86% |
Clinical Reported PFS | 14.6 |
Clinical Reported OS | NA |
Clinical Result source | ClinicalTrials.gov NCT00866047 |
Clinical Program phase | PHASE_2 |
Clinical Trial ref | NCT00866047 |
타깃 · 모달리티 · 임상 근거 · 비임상 맥락으로 최대 5개 프로그램을 나란히 비교합니다. · 다음 갱신 D-6 · 마지막 9월 2일
현재 선택: 1개 · 임상 갱신 필요 1개
프로그램 상세에서 관심 등록 후 2개 이상 모으면 여기서 한 번에 비교할 수 있습니다.
표가 넓으면 좌우로 스크롤하세요. 핵심 비교 모드에서는 중요 항목만 표시됩니다.
| 항목 | |
|---|---|
Overview Program | Antibody-Drug Conjugate Therapy |
Overview Company | Favrille |
Overview Modality | ADC |
Overview Target | FRα |
Overview Indication | Metastatic Bladder Urothelial Carcinoma; Metastatic Renal Pelvis and Ureter Urothelial Carcinoma |
Overview Phase | PHASE_2 |
Overview Status | RECRUITING |
Overview Content status | Standard Database |
Overview Data Confidence | Data Confidence · Medium |
Overview Development Signal | Development Signal · Emerging |
Overview Approval status | Investigational |
Technology Payload | deruxtecan for metastatic breast cancer |
Technology Linker | linker stability influence ocular toxicity |
MoA Mechanism | ADC, while the AKR1C1-WWP2 axis promotes extracellular vesicle-mediated ADC export and clearance, thereby reducing intracellular payload accumulation |
MoA Biomarker | HER2-positive |
PK/PD Half-life | 7 h |
PK/PD Species | Mouse, Human |
PK/PD Animal (cat.) | Human, Mouse, In vitro |
PK/PD Experiment | PD |
Toxicology Species | Mouse, Human |
Toxicology Animal (cat.) | Human, Mouse, In vitro |
Toxicology Major finding | interstitial lung disease (ILD) |
Toxicology CRS | Reported |
Clinical Safety signal | interstitial lung disease (ILD) |
Clinical Selected reported efficacy | ORR 86% |
Clinical Reported ORR | 86% |
Clinical Reported PFS | 14.6 |
Clinical Reported OS | NA |
Clinical Result source | ClinicalTrials.gov NCT00866047 |
Clinical Program phase | PHASE_2 |
Clinical Trial ref | NCT00866047 |
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