구조모아 (StructureMoa)항암 chemical structure spider web
방문타깃 · 모달리티 · 임상 근거 · 비임상 맥락으로 최대 5개 프로그램을 나란히 비교합니다. · 다음 갱신 D-5 · 마지막 9월 2일
현재 선택: 5개 · 임상 갱신 필요 2개
프로그램 상세에서 관심 등록 후 2개 이상 모으면 여기서 한 번에 비교할 수 있습니다.
표가 넓으면 좌우로 스크롤하세요. 핵심 비교 모드에서는 중요 항목만 표시됩니다.
| 항목 | |||||
|---|---|---|---|---|---|
Overview Program | Tremfya (guselkumab) | Stelara (ustekinumab) | Skyrizi (risankizumab-rzaa) | Anti-IL23 | Anti-IL12/23 |
Overview Company | Johnson & Johnson | Johnson & Johnson | AbbVie | Prof. Dr. Stephan Weidinger | Prof. Dr. Stephan Weidinger |
Overview Modality | ANTIBODY | ANTIBODY | ANTIBODY | ANTIBODY | ANTIBODY |
Overview Target | IL-23 p19 | IL-12 / IL-23 (p40) | IL-23 p19 | Atopic Dermatitis | Atopic Dermatitis |
Overview Indication | Plaque psoriasis, psoriatic arthritis, ulcerative colitis, Crohn's disease | Psoriasis, psoriatic arthritis, Crohn's disease, ulcerative colitis | Plaque psoriasis, PsA, Crohn's disease, ulcerative colitis | Atopic Dermatitis; Psoriasis | Atopic Dermatitis; Psoriasis |
Overview Phase | APPROVED | APPROVED | APPROVED | PRECLINICAL | PRECLINICAL |
Overview Status | APPROVED | APPROVED | APPROVED | RECRUITING | RECRUITING |
Overview Content status | Curated Core | Curated Core | Curated Core | Limited Data | Limited Data |
Overview Data Confidence | Data Confidence · High | Data Confidence · High | Data Confidence · High | Data Confidence · Low | Data Confidence · Low |
Overview Development Signal | Development Signal · Established | Development Signal · Established | Development Signal · Established | Development Signal · Watch | Development Signal · Watch |
Overview Approval status | FDA approved | FDA approved | FDA approved | Investigational | Investigational |
Positioning Key differentiator | Leaving IL-12 intact preserves Th1 antimicrobial immunity while shutting down the Th17 axis, which is why durability is high and infection signals are low. | Novel therapeutic avenues, including TYK2 and HDAC inhibitors, as well as nanotechnology-based delivery systems, show encoura | Novel therapeutic avenues, including TYK2 and HDAC inhibitors, as well as nanotechnology-based delivery systems, show encoura | — | — |
Positioning Known limitation | Anti-drug antibodies are rare; non-IL-23-driven fibrostenotic disease does not respond. | IL-23 axis escape, anti-drug antibodies, and non-IL-12/23 inflammation. | IL-17 independent disease and immunogenicity. | — | — |
Positioning Development positioning | IL-23 class benchmark alongside Skyrizi, now with the broadest IBD label progression. | — | — | — | — |
MoA Mechanism | Neutralizes IL-23 by binding p19, blocking IL-23R signaling and downstream Th17/Th22 differentiation, IL-17 production, and tissue inflammation in skin, joints, and gut mucosa. | Ustekinumab binds the p40 subunit shared by IL-12 and IL-23, preventing their interaction with IL-12Rβ1 receptor and downstream Th1/Th17 differentiation and cytokine production. | Risankizumab selectively binds IL-23 p19 subunit, blocking IL-23 interaction with IL-23R and downstream Th17 pathway (IL-17A/F, IL-22). | on multivariate analysis | with high efficacy and safety profiles, sustained total skin clearance, and rapid onset of effect also to psoriasis patients who previously failed or experienced an inadequate response to anti-TNF-α or anti-IL12/2 |
MoA Biomarker | PASI/IGA in psoriasis, ACR20 in PsA, endoscopic improvement and fecal calprotectin in IBD. | biomarkers but require external validation in independent cohorts | PASI, sPGA, IBD endoscopic scores. | biomarkers of downstream IL23-IL23R activity, are now needed to translate IL23 blockade into the clinic | biomarkers independently predicted survival |
PK/PD Half-life | ~15–18 days | 19 h | 28 h | — | — |
PK/PD Species | Cynomolgus monkey, PASI 90/100, ACR20/50, endoscopic remission, serum IL-17A/IL-22 | Mouse, Skin clearance (PASI75/90), endoscopic response in IBD | Mouse | Mouse, pharmacodynamics (PD), and antitumor activity. | Mouse |
PK/PD Animal (cat.) | Human, NHP | Mouse | Mouse | Mouse | Mouse |
PK/PD Experiment | Pharmacokinetic | Pharmacokinetic | Pharmacokinetic | pharmacokinetic | pd |
Toxicology Species | Mouse, Pig | Cynomolgus monkey, Mouse | Cynomolgus monkey, Mouse | Mouse, pharmacodynamics (PD), and antitumor activity. | Mouse |
Toxicology Animal (cat.) | — | — | — | Mouse | Mouse |
Toxicology Major finding | Upper respiratory infection, headache, and injection-site reactions dominate. Serious infection and malignancy signals have stayed low across long-term psoriasis follow-up. | Infections, reversible posterior leukoencephalopathy syndrome (rare), hypersensitivity. | Upper respiratory infections, headache, fatigue; low TB reactivation vs TNF class. | Induction and Prolonged Induction With Mirikizumab in Ulcerative Colitis-A Prospective, Real-World Study From the Sicilian Network for Inflammatory Bowel Disease (SN-IBD).. Mirikizumab (MIRI), an IgG4 monoclonal antibody targeting IL-23 p19, was recently licensed for ulcerative colitis (UC). Most available data come from the pivotal trials, but real-life data are scant. We aimed to evaluate the ef… | Systemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis.. Psoriasis is an immune-mediated disease with either skin or joints manifestations, or both, and it has a major impact on quality of life. Although there is currently no cure for psoriasis, various treatment strategies allow sustained control of disease signs and symptoms. Despite multiple available treatmen… |
Toxicology CRS | N/A | N/A | N/A | — | — |
Clinical Safety signal | Upper respiratory infection, headache, and injection-site reactions dominate. Serious infection and malignancy signals have stayed low across long-term psoriasis follow-up. | Infections, reversible posterior leukoencephalopathy syndrome (rare), hypersensitivity. | Upper respiratory infections, headache, fatigue; low TB reactivation vs TNF class. | Induction and Prolonged Induction With Mirikizumab in Ulcerative Colitis-A Prospective, Real-World Study From the Sicilian Network for Inflammatory Bowel Disease (SN-IBD).. Mirikizumab (MIRI), an IgG4 monoclonal antibody targeting IL-23 p19, was recently licensed for ulcerative colitis (UC). Most available data come from the pivotal trials, but real-life data are scant. We aimed to evaluate the ef… | Systemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis.. Psoriasis is an immune-mediated disease with either skin or joints manifestations, or both, and it has a major impact on quality of life. Although there is currently no cure for psoriasis, various treatment strategies allow sustained control of disease signs and symptoms. Despite multiple available treatmen… |
Clinical Selected reported efficacy | — | PASI75 67% | — | — | — |
Clinical PASI75 | — | 67% | — | — | — |
Clinical Result source | — | PHOENIX | — | — | — |
Clinical Program phase | APPROVED | APPROVED | APPROVED | PRECLINICAL | PRECLINICAL |
Clinical Trial activity | No active/completed counts | No active/completed counts | No active/completed counts | — | — |
Clinical Trial ref | — | PHOENIX | — | — | — |
Preclinical Animal (cat.) | Mouse | — | Mouse | Mouse | — |
타깃 · 모달리티 · 임상 근거 · 비임상 맥락으로 최대 5개 프로그램을 나란히 비교합니다. · 다음 갱신 D-5 · 마지막 9월 2일
현재 선택: 5개 · 임상 갱신 필요 2개
프로그램 상세에서 관심 등록 후 2개 이상 모으면 여기서 한 번에 비교할 수 있습니다.
표가 넓으면 좌우로 스크롤하세요. 핵심 비교 모드에서는 중요 항목만 표시됩니다.
| 항목 | |||||
|---|---|---|---|---|---|
Overview Program | Tremfya (guselkumab) | Stelara (ustekinumab) | Skyrizi (risankizumab-rzaa) | Anti-IL23 | Anti-IL12/23 |
Overview Company | Johnson & Johnson | Johnson & Johnson | AbbVie | Prof. Dr. Stephan Weidinger | Prof. Dr. Stephan Weidinger |
Overview Modality | ANTIBODY | ANTIBODY | ANTIBODY | ANTIBODY | ANTIBODY |
Overview Target | IL-23 p19 | IL-12 / IL-23 (p40) | IL-23 p19 | Atopic Dermatitis | Atopic Dermatitis |
Overview Indication | Plaque psoriasis, psoriatic arthritis, ulcerative colitis, Crohn's disease | Psoriasis, psoriatic arthritis, Crohn's disease, ulcerative colitis | Plaque psoriasis, PsA, Crohn's disease, ulcerative colitis | Atopic Dermatitis; Psoriasis | Atopic Dermatitis; Psoriasis |
Overview Phase | APPROVED | APPROVED | APPROVED | PRECLINICAL | PRECLINICAL |
Overview Status | APPROVED | APPROVED | APPROVED | RECRUITING | RECRUITING |
Overview Content status | Curated Core | Curated Core | Curated Core | Limited Data | Limited Data |
Overview Data Confidence | Data Confidence · High | Data Confidence · High | Data Confidence · High | Data Confidence · Low | Data Confidence · Low |
Overview Development Signal | Development Signal · Established | Development Signal · Established | Development Signal · Established | Development Signal · Watch | Development Signal · Watch |
Overview Approval status | FDA approved | FDA approved | FDA approved | Investigational | Investigational |
Positioning Key differentiator | Leaving IL-12 intact preserves Th1 antimicrobial immunity while shutting down the Th17 axis, which is why durability is high and infection signals are low. | Novel therapeutic avenues, including TYK2 and HDAC inhibitors, as well as nanotechnology-based delivery systems, show encoura | Novel therapeutic avenues, including TYK2 and HDAC inhibitors, as well as nanotechnology-based delivery systems, show encoura | — | — |
Positioning Known limitation | Anti-drug antibodies are rare; non-IL-23-driven fibrostenotic disease does not respond. | IL-23 axis escape, anti-drug antibodies, and non-IL-12/23 inflammation. | IL-17 independent disease and immunogenicity. | — | — |
Positioning Development positioning | IL-23 class benchmark alongside Skyrizi, now with the broadest IBD label progression. | — | — | — | — |
MoA Mechanism | Neutralizes IL-23 by binding p19, blocking IL-23R signaling and downstream Th17/Th22 differentiation, IL-17 production, and tissue inflammation in skin, joints, and gut mucosa. | Ustekinumab binds the p40 subunit shared by IL-12 and IL-23, preventing their interaction with IL-12Rβ1 receptor and downstream Th1/Th17 differentiation and cytokine production. | Risankizumab selectively binds IL-23 p19 subunit, blocking IL-23 interaction with IL-23R and downstream Th17 pathway (IL-17A/F, IL-22). | on multivariate analysis | with high efficacy and safety profiles, sustained total skin clearance, and rapid onset of effect also to psoriasis patients who previously failed or experienced an inadequate response to anti-TNF-α or anti-IL12/2 |
MoA Biomarker | PASI/IGA in psoriasis, ACR20 in PsA, endoscopic improvement and fecal calprotectin in IBD. | biomarkers but require external validation in independent cohorts | PASI, sPGA, IBD endoscopic scores. | biomarkers of downstream IL23-IL23R activity, are now needed to translate IL23 blockade into the clinic | biomarkers independently predicted survival |
PK/PD Half-life | ~15–18 days | 19 h | 28 h | — | — |
PK/PD Species | Cynomolgus monkey, PASI 90/100, ACR20/50, endoscopic remission, serum IL-17A/IL-22 | Mouse, Skin clearance (PASI75/90), endoscopic response in IBD | Mouse | Mouse, pharmacodynamics (PD), and antitumor activity. | Mouse |
PK/PD Animal (cat.) | Human, NHP | Mouse | Mouse | Mouse | Mouse |
PK/PD Experiment | Pharmacokinetic | Pharmacokinetic | Pharmacokinetic | pharmacokinetic | pd |
Toxicology Species | Mouse, Pig | Cynomolgus monkey, Mouse | Cynomolgus monkey, Mouse | Mouse, pharmacodynamics (PD), and antitumor activity. | Mouse |
Toxicology Animal (cat.) | — | — | — | Mouse | Mouse |
Toxicology Major finding | Upper respiratory infection, headache, and injection-site reactions dominate. Serious infection and malignancy signals have stayed low across long-term psoriasis follow-up. | Infections, reversible posterior leukoencephalopathy syndrome (rare), hypersensitivity. | Upper respiratory infections, headache, fatigue; low TB reactivation vs TNF class. | Induction and Prolonged Induction With Mirikizumab in Ulcerative Colitis-A Prospective, Real-World Study From the Sicilian Network for Inflammatory Bowel Disease (SN-IBD).. Mirikizumab (MIRI), an IgG4 monoclonal antibody targeting IL-23 p19, was recently licensed for ulcerative colitis (UC). Most available data come from the pivotal trials, but real-life data are scant. We aimed to evaluate the ef… | Systemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis.. Psoriasis is an immune-mediated disease with either skin or joints manifestations, or both, and it has a major impact on quality of life. Although there is currently no cure for psoriasis, various treatment strategies allow sustained control of disease signs and symptoms. Despite multiple available treatmen… |
Toxicology CRS | N/A | N/A | N/A | — | — |
Clinical Safety signal | Upper respiratory infection, headache, and injection-site reactions dominate. Serious infection and malignancy signals have stayed low across long-term psoriasis follow-up. | Infections, reversible posterior leukoencephalopathy syndrome (rare), hypersensitivity. | Upper respiratory infections, headache, fatigue; low TB reactivation vs TNF class. | Induction and Prolonged Induction With Mirikizumab in Ulcerative Colitis-A Prospective, Real-World Study From the Sicilian Network for Inflammatory Bowel Disease (SN-IBD).. Mirikizumab (MIRI), an IgG4 monoclonal antibody targeting IL-23 p19, was recently licensed for ulcerative colitis (UC). Most available data come from the pivotal trials, but real-life data are scant. We aimed to evaluate the ef… | Systemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis.. Psoriasis is an immune-mediated disease with either skin or joints manifestations, or both, and it has a major impact on quality of life. Although there is currently no cure for psoriasis, various treatment strategies allow sustained control of disease signs and symptoms. Despite multiple available treatmen… |
Clinical Selected reported efficacy | — | PASI75 67% | — | — | — |
Clinical PASI75 | — | 67% | — | — | — |
Clinical Result source | — | PHOENIX | — | — | — |
Clinical Program phase | APPROVED | APPROVED | APPROVED | PRECLINICAL | PRECLINICAL |
Clinical Trial activity | No active/completed counts | No active/completed counts | No active/completed counts | — | — |
Clinical Trial ref | — | PHOENIX | — | — | — |
Preclinical Animal (cat.) | Mouse | — | Mouse | Mouse | — |
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