구조모아 (StructureMoa)항암 chemical structure spider web
방문타깃 · 모달리티 · 임상 근거 · 비임상 맥락으로 최대 5개 프로그램을 나란히 비교합니다. · 다음 갱신 D-6 · 마지막 9월 2일
현재 선택: 1개 · 임상 갱신 필요 1개
프로그램 상세에서 관심 등록 후 2개 이상 모으면 여기서 한 번에 비교할 수 있습니다.
표가 넓으면 좌우로 스크롤하세요. 핵심 비교 모드에서는 중요 항목만 표시됩니다.
| 항목 | |
|---|---|
Overview Program | Toripalimab |
Overview Company | Junshi Biosciences |
Overview Modality | ANTIBODY |
Overview Target | Gastric Cancer |
Overview Indication | Metastatic Colorectal Cancer; Liver Metastases |
Overview Phase | PHASE_3 |
Overview Status | RECRUITING |
Overview Content status | Curated Core |
Overview Data Confidence | Data Confidence · High |
Overview Development Signal | Development Signal · Emerging |
Overview Approval status | Investigational |
Positioning Key differentiator | novel safety signals were identified |
Positioning Known limitation | downregulation of p-Akt and Ki-67 |
MoA Mechanism | Binding of the PD-1 ligands, PD-L1 and PD-L2, to the PD-1 receptor found on T cells, inhibits T cell proliferation and cytokine production |
MoA Biomarker | PD-L1)-positive |
PK/PD Species | Rat |
PK/PD Animal (cat.) | Rat, In vitro |
PK/PD Experiment | PD |
Toxicology Species | Rat |
Toxicology Animal (cat.) | Rat, In vitro |
Toxicology Major finding | Thrombocytopenia and Splenomegaly in Locally Advanced Rectal Cancer Patients Receiving Total Neo |
Clinical Safety signal | Thrombocytopenia and Splenomegaly in Locally Advanced Rectal Cancer Patients Receiving Total Neo |
Clinical Selected reported efficacy | ORR 75.5% |
Clinical Reported ORR | 75.5% |
Clinical Reported PFS | 8.2 |
Clinical Reported OS | 33.7 |
Clinical Result source | ClinicalTrials.gov NCT03581786 |
Clinical Program phase | PHASE_3 |
Clinical Trial activity | No active/completed counts |
Clinical Trial ref | NCT03581786 |
타깃 · 모달리티 · 임상 근거 · 비임상 맥락으로 최대 5개 프로그램을 나란히 비교합니다. · 다음 갱신 D-6 · 마지막 9월 2일
현재 선택: 1개 · 임상 갱신 필요 1개
프로그램 상세에서 관심 등록 후 2개 이상 모으면 여기서 한 번에 비교할 수 있습니다.
표가 넓으면 좌우로 스크롤하세요. 핵심 비교 모드에서는 중요 항목만 표시됩니다.
| 항목 | |
|---|---|
Overview Program | Toripalimab |
Overview Company | Junshi Biosciences |
Overview Modality | ANTIBODY |
Overview Target | Gastric Cancer |
Overview Indication | Metastatic Colorectal Cancer; Liver Metastases |
Overview Phase | PHASE_3 |
Overview Status | RECRUITING |
Overview Content status | Curated Core |
Overview Data Confidence | Data Confidence · High |
Overview Development Signal | Development Signal · Emerging |
Overview Approval status | Investigational |
Positioning Key differentiator | novel safety signals were identified |
Positioning Known limitation | downregulation of p-Akt and Ki-67 |
MoA Mechanism | Binding of the PD-1 ligands, PD-L1 and PD-L2, to the PD-1 receptor found on T cells, inhibits T cell proliferation and cytokine production |
MoA Biomarker | PD-L1)-positive |
PK/PD Species | Rat |
PK/PD Animal (cat.) | Rat, In vitro |
PK/PD Experiment | PD |
Toxicology Species | Rat |
Toxicology Animal (cat.) | Rat, In vitro |
Toxicology Major finding | Thrombocytopenia and Splenomegaly in Locally Advanced Rectal Cancer Patients Receiving Total Neo |
Clinical Safety signal | Thrombocytopenia and Splenomegaly in Locally Advanced Rectal Cancer Patients Receiving Total Neo |
Clinical Selected reported efficacy | ORR 75.5% |
Clinical Reported ORR | 75.5% |
Clinical Reported PFS | 8.2 |
Clinical Reported OS | 33.7 |
Clinical Result source | ClinicalTrials.gov NCT03581786 |
Clinical Program phase | PHASE_3 |
Clinical Trial activity | No active/completed counts |
Clinical Trial ref | NCT03581786 |
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