구조모아 (StructureMoa)항암 chemical structure spider web
방문타깃 · 모달리티 · 임상 근거 · 비임상 맥락으로 최대 5개 프로그램을 나란히 비교합니다. · 다음 갱신 D-6 · 마지막 9월 2일
현재 선택: 1개 · 임상 갱신 필요 1개
프로그램 상세에서 관심 등록 후 2개 이상 모으면 여기서 한 번에 비교할 수 있습니다.
표가 넓으면 좌우로 스크롤하세요. 핵심 비교 모드에서는 중요 항목만 표시됩니다.
| 항목 | |
|---|---|
Overview Program | Obinutuzumab |
Overview Company | Roche / Genentech |
Overview Modality | ANTIBODY |
Overview Target | B-cell Lymphoma |
Overview Indication | Breast Adenocarcinoma; Metastatic Breast Carcinoma |
Overview Phase | PHASE_3 |
Overview Status | RECRUITING |
Overview Content status | Curated Core |
Overview Data Confidence | Data Confidence · High |
Overview Development Signal | Development Signal · Emerging |
Overview Approval status | Investigational |
Positioning Key differentiator | novel calcineurin inhibitor with predictable pharmacokinetics, increases complete renal response rates and rapidly reduces pr |
Positioning Known limitation | resistance to treatment |
MoA Mechanism | targets type I interferon signaling |
MoA Biomarker | biomarker to guide treatment duration in two prospective trials of venetoclax- and sonrotoclax-based triplets |
PK/PD Species | Cynomolgus monkey, Macaque, Mouse |
PK/PD Animal (cat.) | Mouse, NHP, Monkey |
PK/PD Experiment | Pharmacodynamic |
Toxicology Species | Cynomolgus monkey, Macaque, Mouse |
Toxicology Animal (cat.) | Mouse, NHP, Monkey |
Toxicology Major finding | thrombocytopenia or organ dysfunction, were documented |
Toxicology CRS | Reported |
Clinical Safety signal | thrombocytopenia or organ dysfunction, were documented |
Clinical Selected reported efficacy | ORR 100% |
Clinical Reported ORR | 100.0% |
Clinical Result source | ClinicalTrials.gov NCT02611323 |
Clinical Program phase | PHASE_3 |
Clinical Trial activity | No active/completed counts |
Clinical Trial ref | NCT02611323 |
타깃 · 모달리티 · 임상 근거 · 비임상 맥락으로 최대 5개 프로그램을 나란히 비교합니다. · 다음 갱신 D-6 · 마지막 9월 2일
현재 선택: 1개 · 임상 갱신 필요 1개
프로그램 상세에서 관심 등록 후 2개 이상 모으면 여기서 한 번에 비교할 수 있습니다.
표가 넓으면 좌우로 스크롤하세요. 핵심 비교 모드에서는 중요 항목만 표시됩니다.
| 항목 | |
|---|---|
Overview Program | Obinutuzumab |
Overview Company | Roche / Genentech |
Overview Modality | ANTIBODY |
Overview Target | B-cell Lymphoma |
Overview Indication | Breast Adenocarcinoma; Metastatic Breast Carcinoma |
Overview Phase | PHASE_3 |
Overview Status | RECRUITING |
Overview Content status | Curated Core |
Overview Data Confidence | Data Confidence · High |
Overview Development Signal | Development Signal · Emerging |
Overview Approval status | Investigational |
Positioning Key differentiator | novel calcineurin inhibitor with predictable pharmacokinetics, increases complete renal response rates and rapidly reduces pr |
Positioning Known limitation | resistance to treatment |
MoA Mechanism | targets type I interferon signaling |
MoA Biomarker | biomarker to guide treatment duration in two prospective trials of venetoclax- and sonrotoclax-based triplets |
PK/PD Species | Cynomolgus monkey, Macaque, Mouse |
PK/PD Animal (cat.) | Mouse, NHP, Monkey |
PK/PD Experiment | Pharmacodynamic |
Toxicology Species | Cynomolgus monkey, Macaque, Mouse |
Toxicology Animal (cat.) | Mouse, NHP, Monkey |
Toxicology Major finding | thrombocytopenia or organ dysfunction, were documented |
Toxicology CRS | Reported |
Clinical Safety signal | thrombocytopenia or organ dysfunction, were documented |
Clinical Selected reported efficacy | ORR 100% |
Clinical Reported ORR | 100.0% |
Clinical Result source | ClinicalTrials.gov NCT02611323 |
Clinical Program phase | PHASE_3 |
Clinical Trial activity | No active/completed counts |
Clinical Trial ref | NCT02611323 |
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