구조모아 (StructureMoa)항암 chemical structure spider web
방문타깃 · 모달리티 · 임상 근거 · 비임상 맥락으로 최대 5개 프로그램을 나란히 비교합니다. · 다음 갱신 D-5 · 마지막 9월 2일
현재 선택: 1개 · 임상 갱신 필요 1개
프로그램 상세에서 관심 등록 후 2개 이상 모으면 여기서 한 번에 비교할 수 있습니다.
표가 넓으면 좌우로 스크롤하세요. 핵심 비교 모드에서는 중요 항목만 표시됩니다.
| 항목 | |
|---|---|
Overview Program | Mercaptopurine |
Overview Company | Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives |
Overview Modality | ADC |
Overview Target | Leukemia |
Overview Indication | Recurrent B-Cell Childhood Acute Lymphoblastic Leukemia; Recurrent Childhood B-Lymphoblastic Lymphoma |
Overview Phase | PHASE_2 |
Overview Status | ACTIVE |
Overview Content status | Limited Data |
Overview Data Confidence | Data Confidence · Low |
Overview Development Signal | Development Signal · Emerging |
Overview Approval status | Investigational |
MoA Mechanism | Mercaptopurine is a purine analog that undergoes intracellular transport and activation to form metabolites including thioguanine nucleotides (TGNs) |
MoA Biomarker | biomarker discovery for thiopurine response in Crohn disease: Plasma histidine as a promising biomarker |
PK/PD Species | Mouse |
PK/PD Animal (cat.) | Mouse, In vitro |
PK/PD Experiment | pd |
Toxicology Species | Mouse |
Toxicology Animal (cat.) | Mouse |
Toxicology Major finding | thrombocytopenia with elevated metabolite levels that required stopping mercaptopurine |
Clinical Safety signal | thrombocytopenia with elevated metabolite levels that required stopping mercaptopurine |
Clinical Selected reported efficacy | ORR 79.2% |
Clinical Reported ORR | 79.2% |
Clinical Reported OS | 79.2 |
Clinical Result source | ClinicalTrials.gov NCT00075725 |
Clinical Program phase | PHASE_2 |
Clinical Trial activity | No active/completed counts |
Clinical Trial ref | NCT00075725 |
타깃 · 모달리티 · 임상 근거 · 비임상 맥락으로 최대 5개 프로그램을 나란히 비교합니다. · 다음 갱신 D-5 · 마지막 9월 2일
현재 선택: 1개 · 임상 갱신 필요 1개
프로그램 상세에서 관심 등록 후 2개 이상 모으면 여기서 한 번에 비교할 수 있습니다.
표가 넓으면 좌우로 스크롤하세요. 핵심 비교 모드에서는 중요 항목만 표시됩니다.
| 항목 | |
|---|---|
Overview Program | Mercaptopurine |
Overview Company | Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives |
Overview Modality | ADC |
Overview Target | Leukemia |
Overview Indication | Recurrent B-Cell Childhood Acute Lymphoblastic Leukemia; Recurrent Childhood B-Lymphoblastic Lymphoma |
Overview Phase | PHASE_2 |
Overview Status | ACTIVE |
Overview Content status | Limited Data |
Overview Data Confidence | Data Confidence · Low |
Overview Development Signal | Development Signal · Emerging |
Overview Approval status | Investigational |
MoA Mechanism | Mercaptopurine is a purine analog that undergoes intracellular transport and activation to form metabolites including thioguanine nucleotides (TGNs) |
MoA Biomarker | biomarker discovery for thiopurine response in Crohn disease: Plasma histidine as a promising biomarker |
PK/PD Species | Mouse |
PK/PD Animal (cat.) | Mouse, In vitro |
PK/PD Experiment | pd |
Toxicology Species | Mouse |
Toxicology Animal (cat.) | Mouse |
Toxicology Major finding | thrombocytopenia with elevated metabolite levels that required stopping mercaptopurine |
Clinical Safety signal | thrombocytopenia with elevated metabolite levels that required stopping mercaptopurine |
Clinical Selected reported efficacy | ORR 79.2% |
Clinical Reported ORR | 79.2% |
Clinical Reported OS | 79.2 |
Clinical Result source | ClinicalTrials.gov NCT00075725 |
Clinical Program phase | PHASE_2 |
Clinical Trial activity | No active/completed counts |
Clinical Trial ref | NCT00075725 |
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