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항목
CGTStandard DatabasestalePreclinical
JCAR015 (JCAR015)
Juno Therapeutics, a Subsidiary of…·Acute Lymphoblastic Leukemia
3 trials
Overview
Program
JCAR015
Overview
Company
Juno Therapeutics, a Subsidiary of Celgene
Overview
Modality
CGT
Overview
Target
Acute Lymphoblastic Leukemia
Overview
Indication
Acute Lymphoblastic Leukemia
Overview
Phase
PRECLINICAL
Overview
Status
ACTIVE
Overview
Content status
Standard Database
Overview
Data Confidence
Data Confidence · Medium
Overview
Development Signal
Development Signal · Watch
Overview
Approval status
Investigational
Toxicology
Major finding
Fludarabine and neurotoxicity in engineered T-cell therapy.. Adoptive T-cell therapy, incorporating engineered T cell receptors (TCRs) or chimeric antigen receptors (CARs), target tumor antigens with high affinity and specificity. To increase the potency of adoptively transferred T cells, patients are conditioned with lymphodepleting chemotherapy regimens prior to adoptive T-cell transfer (ACT), a…
Toxicology
CRS
Reported
Clinical
Safety signal
Fludarabine and neurotoxicity in engineered T-cell therapy.. Adoptive T-cell therapy, incorporating engineered T cell receptors (TCRs) or chimeric antigen receptors (CARs), target tumor antigens with high affinity and specificity. To increase the potency of adoptively transferred T cells, patients are conditioned with lymphodepleting chemotherapy regimens prior to adoptive T-cell transfer (ACT), a…
Clinical
Program phase
PRECLINICAL