구조모아 (StructureMoa)항암 chemical structure spider web
방문타깃 · 모달리티 · 임상 근거 · 비임상 맥락으로 최대 5개 프로그램을 나란히 비교합니다. · 다음 갱신 D-6 · 마지막 9월 2일
현재 선택: 1개 · 임상 갱신 필요 1개
프로그램 상세에서 관심 등록 후 2개 이상 모으면 여기서 한 번에 비교할 수 있습니다.
표가 넓으면 좌우로 스크롤하세요. 핵심 비교 모드에서는 중요 항목만 표시됩니다.
| 항목 | High (injection of scAAV2-P1ND4v2 2.4 X10e10vg, injection of scAAV2-P1ND4v2 2.4 X10e10vg (High)) National Eye Institute (NEI)·Leber's Hereditary Optic Neuropath… 61 trials |
|---|---|
Overview Program | injection of scAAV2-P1ND4v2 2.4 X10e10vg (High) |
Overview Company | National Eye Institute (NEI) |
Overview Modality | CGT |
Overview Target | Leber's Hereditary Optic Neuropathy |
Overview Indication | Leber's Hereditary Optic Neuropathy |
Overview Phase | PHASE_1 |
Overview Status | ACTIVE |
Overview Content status | Standard Database |
Overview Data Confidence | Data Confidence · Medium |
Overview Development Signal | Development Signal · Watch |
Overview Approval status | Investigational |
Technology Vector | retroviral therapy (ART), yet evidence from sub-Saharan Africa remains limited |
MoA Mechanism | checkpoint inhibitor‑induced myocarditis from direct cardiac invasion in patients with lung cancer, particul |
MoA Biomarker | biomarkers normalized |
PK/PD Species | Mouse |
PK/PD Animal (cat.) | Mouse, In vitro |
PK/PD Experiment | PD |
Toxicology Species | Mouse |
Toxicology Animal (cat.) | Mouse, In vitro |
Toxicology Major finding | Nitric Oxide-Mediated Modulation of Photorespiratory Enzymes and Photochemical Components in Leaves of Pea Plants (Pisum sativum).. The photorespiratory metabolism safeguards photosynthesis against abiotic and biotic stress. Nitric oxide (NO) and reactive oxygen species (ROS) levels rise in plants during abiotic stress. Low concentrations of NO or ROS are beneficial as signalling molecules, but th… |
Toxicology CRS | Reported |
Clinical Safety signal | Nitric Oxide-Mediated Modulation of Photorespiratory Enzymes and Photochemical Components in Leaves of Pea Plants (Pisum sativum).. The photorespiratory metabolism safeguards photosynthesis against abiotic and biotic stress. Nitric oxide (NO) and reactive oxygen species (ROS) levels rise in plants during abiotic stress. Low concentrations of NO or ROS are beneficial as signalling molecules, but th… |
Clinical Result source | ClinicalTrials.gov NCT02161380 |
Clinical Program phase | PHASE_1 |
Clinical Trial ref | NCT02161380 |
타깃 · 모달리티 · 임상 근거 · 비임상 맥락으로 최대 5개 프로그램을 나란히 비교합니다. · 다음 갱신 D-6 · 마지막 9월 2일
현재 선택: 1개 · 임상 갱신 필요 1개
프로그램 상세에서 관심 등록 후 2개 이상 모으면 여기서 한 번에 비교할 수 있습니다.
표가 넓으면 좌우로 스크롤하세요. 핵심 비교 모드에서는 중요 항목만 표시됩니다.
| 항목 | High (injection of scAAV2-P1ND4v2 2.4 X10e10vg, injection of scAAV2-P1ND4v2 2.4 X10e10vg (High)) National Eye Institute (NEI)·Leber's Hereditary Optic Neuropath… 61 trials |
|---|---|
Overview Program | injection of scAAV2-P1ND4v2 2.4 X10e10vg (High) |
Overview Company | National Eye Institute (NEI) |
Overview Modality | CGT |
Overview Target | Leber's Hereditary Optic Neuropathy |
Overview Indication | Leber's Hereditary Optic Neuropathy |
Overview Phase | PHASE_1 |
Overview Status | ACTIVE |
Overview Content status | Standard Database |
Overview Data Confidence | Data Confidence · Medium |
Overview Development Signal | Development Signal · Watch |
Overview Approval status | Investigational |
Technology Vector | retroviral therapy (ART), yet evidence from sub-Saharan Africa remains limited |
MoA Mechanism | checkpoint inhibitor‑induced myocarditis from direct cardiac invasion in patients with lung cancer, particul |
MoA Biomarker | biomarkers normalized |
PK/PD Species | Mouse |
PK/PD Animal (cat.) | Mouse, In vitro |
PK/PD Experiment | PD |
Toxicology Species | Mouse |
Toxicology Animal (cat.) | Mouse, In vitro |
Toxicology Major finding | Nitric Oxide-Mediated Modulation of Photorespiratory Enzymes and Photochemical Components in Leaves of Pea Plants (Pisum sativum).. The photorespiratory metabolism safeguards photosynthesis against abiotic and biotic stress. Nitric oxide (NO) and reactive oxygen species (ROS) levels rise in plants during abiotic stress. Low concentrations of NO or ROS are beneficial as signalling molecules, but th… |
Toxicology CRS | Reported |
Clinical Safety signal | Nitric Oxide-Mediated Modulation of Photorespiratory Enzymes and Photochemical Components in Leaves of Pea Plants (Pisum sativum).. The photorespiratory metabolism safeguards photosynthesis against abiotic and biotic stress. Nitric oxide (NO) and reactive oxygen species (ROS) levels rise in plants during abiotic stress. Low concentrations of NO or ROS are beneficial as signalling molecules, but th… |
Clinical Result source | ClinicalTrials.gov NCT02161380 |
Clinical Program phase | PHASE_1 |
Clinical Trial ref | NCT02161380 |
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