구조모아 (StructureMoa)항암 chemical structure spider web
방문타깃 · 모달리티 · 임상 근거 · 비임상 맥락으로 최대 5개 프로그램을 나란히 비교합니다. · 다음 갱신 D-6 · 마지막 9월 2일
현재 선택: 1개 · 임상 갱신 필요 1개
프로그램 상세에서 관심 등록 후 2개 이상 모으면 여기서 한 번에 비교할 수 있습니다.
표가 넓으면 좌우로 스크롤하세요. 핵심 비교 모드에서는 중요 항목만 표시됩니다.
| 항목 | |
|---|---|
Overview Program | Dostarlimab |
Overview Company | GlaxoSmithKline |
Overview Modality | ANTIBODY |
Overview Target | Stomach Neoplasm |
Overview Indication | Neoplasms |
Overview Phase | PHASE_2 |
Overview Status | DISCONTINUED |
Overview Content status | Curated Core |
Overview Data Confidence | Data Confidence · High |
Overview Development Signal | Development Signal · Emerging |
Overview Approval status | Investigational |
Positioning Key differentiator | novel therapeutic strategy for advanced platinum refractory PSCC |
Positioning Known limitation | escape of tumour cells from immune surveillance |
MoA Mechanism | target programmed death receptor |
MoA Biomarker | biomarkers, and patient-reported outcomes will also be assessed |
PK/PD Half-life | 23.5 h |
PK/PD Species | Cynomolgus monkey, Mouse |
PK/PD Animal (cat.) | Mouse, NHP |
PK/PD Experiment | PD |
Toxicology Species | Cynomolgus monkey, Mouse |
Toxicology Animal (cat.) | Mouse, NHP |
Toxicology Major finding | thrombocytopenia triggered by dostarlimab in a patient with endometrial carcinoma: first reporte |
Toxicology CRS | 4% |
Clinical Safety signal | thrombocytopenia triggered by dostarlimab in a patient with endometrial carcinoma: first reporte |
Clinical Reported ORR | 0% |
Clinical Reported PFS | 0 |
Clinical Result source | ClinicalTrials.gov NCT04544995 |
Clinical Program phase | PHASE_2 |
Clinical Trial ref | NCT04544995 |
타깃 · 모달리티 · 임상 근거 · 비임상 맥락으로 최대 5개 프로그램을 나란히 비교합니다. · 다음 갱신 D-6 · 마지막 9월 2일
현재 선택: 1개 · 임상 갱신 필요 1개
프로그램 상세에서 관심 등록 후 2개 이상 모으면 여기서 한 번에 비교할 수 있습니다.
표가 넓으면 좌우로 스크롤하세요. 핵심 비교 모드에서는 중요 항목만 표시됩니다.
| 항목 | |
|---|---|
Overview Program | Dostarlimab |
Overview Company | GlaxoSmithKline |
Overview Modality | ANTIBODY |
Overview Target | Stomach Neoplasm |
Overview Indication | Neoplasms |
Overview Phase | PHASE_2 |
Overview Status | DISCONTINUED |
Overview Content status | Curated Core |
Overview Data Confidence | Data Confidence · High |
Overview Development Signal | Development Signal · Emerging |
Overview Approval status | Investigational |
Positioning Key differentiator | novel therapeutic strategy for advanced platinum refractory PSCC |
Positioning Known limitation | escape of tumour cells from immune surveillance |
MoA Mechanism | target programmed death receptor |
MoA Biomarker | biomarkers, and patient-reported outcomes will also be assessed |
PK/PD Half-life | 23.5 h |
PK/PD Species | Cynomolgus monkey, Mouse |
PK/PD Animal (cat.) | Mouse, NHP |
PK/PD Experiment | PD |
Toxicology Species | Cynomolgus monkey, Mouse |
Toxicology Animal (cat.) | Mouse, NHP |
Toxicology Major finding | thrombocytopenia triggered by dostarlimab in a patient with endometrial carcinoma: first reporte |
Toxicology CRS | 4% |
Clinical Safety signal | thrombocytopenia triggered by dostarlimab in a patient with endometrial carcinoma: first reporte |
Clinical Reported ORR | 0% |
Clinical Reported PFS | 0 |
Clinical Result source | ClinicalTrials.gov NCT04544995 |
Clinical Program phase | PHASE_2 |
Clinical Trial ref | NCT04544995 |
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