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항목
CGTStandard DatabasestalePhase 1
CLL-1.CAR T cells (CLL-1.CAR T cells)
Baylor College of Medicine·Acute Myeloid Leukemia
1 trials
Overview
Program
CLL-1.CAR T cells
Overview
Company
Baylor College of Medicine
Overview
Modality
CGT
Overview
Target
Acute Myeloid Leukemia
Overview
Indication
Acute Myeloid Leukemia
Overview
Phase
PHASE_1
Overview
Status
RECRUITING
Overview
Content status
Standard Database
Overview
Data Confidence
Data Confidence · Medium
Overview
Development Signal
Development Signal · Watch
Overview
Approval status
Investigational
Toxicology
Major finding
Nanobody-Engineered CLL-1 CAR T Cells: Optimizing Tumor-Specific Cytotoxicity and Minimizing Off-Tumor Toxicity.. Acute myeloid leukemia (AML) is an aggressive hematologic malignancy characterized by the rapid expansion of undifferentiated myeloid progenitors, leading to impaired hematopoiesis and poor patient prognosis. Although chimeric antigen receptor (CAR) T-cell therapy using single-chain va…
Toxicology
CRS
Reported
Clinical
Safety signal
Nanobody-Engineered CLL-1 CAR T Cells: Optimizing Tumor-Specific Cytotoxicity and Minimizing Off-Tumor Toxicity.. Acute myeloid leukemia (AML) is an aggressive hematologic malignancy characterized by the rapid expansion of undifferentiated myeloid progenitors, leading to impaired hematopoiesis and poor patient prognosis. Although chimeric antigen receptor (CAR) T-cell therapy using single-chain va…
Clinical
Reported ORR
0%
Clinical
Result source
ClinicalTrials.gov NCT04789408
Clinical
Program phase
PHASE_1
Clinical
Trial ref
NCT04789408