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항목
AntibodyLimited DatastaleApproved
Certolizumab (Certolizumab)
UCB Pharma·Chronic Nonbacterial Osteomyelitis
59 trials·t½ 14 h
Overview
Program
Certolizumab
Overview
Company
UCB Pharma
Overview
Modality
ANTIBODY
Overview
Target
Chronic Nonbacterial Osteomyelitis
Overview
Indication
Psoriasis; Atopic Dermatitis
Overview
Phase
APPROVED
Overview
Status
RECRUITING
Overview
Content status
Limited Data
Overview
Data Confidence
Data Confidence · Low
Overview
Development Signal
Development Signal · Established
Overview
Approval status
Approved (flag incomplete)
MoA
Mechanism
Targeted immunotherapies provide effective interventions by disrupting these cytokine-driven pathway
MoA
Biomarker
biomarkers linked to clinical remission in RA is currently a challenge
PK/PD
Half-life
14 h
PK/PD
Species
Mouse
PK/PD
Animal (cat.)
Mouse
PK/PD
Experiment
Pharmacokinetic
Toxicology
Species
Mouse
Toxicology
Animal (cat.)
Mouse
Toxicology
Major finding
Biologic drugs for induction and maintenance of remission in Crohn's disease: a network meta-analysis.. Crohn's disease is an inflammatory bowel disease (IBD) that can extend to any part of the gut. Many people with Crohn's disease fail to reach and maintain remission using conventional therapies. Biologic therapies with different mechanisms have advanced rapidly over recent decades. Comparative d…
Clinical
Safety signal
Biologic drugs for induction and maintenance of remission in Crohn's disease: a network meta-analysis.. Crohn's disease is an inflammatory bowel disease (IBD) that can extend to any part of the gut. Many people with Crohn's disease fail to reach and maintain remission using conventional therapies. Biologic therapies with different mechanisms have advanced rapidly over recent decades. Comparative d…
Clinical
Result source
ClinicalTrials.gov NCT00845663
Clinical
Program phase
APPROVED
Clinical
Trial ref
NCT00845663