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항목
CGTStandard DatabasestalePreclinical
CD22 CAR T cells (CD22 CAR T cells)
Beijing GoBroad Hospital·CD22
1 trials
Overview
Program
CD22 CAR T cells
Overview
Company
Beijing GoBroad Hospital
Overview
Modality
CGT
Overview
Target
CD22
Overview
Indication
B-cell Acute Lymphoblastic Leukemia; Acute Lymphoblastic Leukemia, in Relapse
Overview
Phase
PRECLINICAL
Overview
Status
RECRUITING
Overview
Content status
Standard Database
Overview
Data Confidence
Data Confidence · Medium
Overview
Development Signal
Development Signal · Watch
Overview
Approval status
Investigational
Toxicology
Major finding
Reprogramming CD22 CAR-T cells in vivo using CD8-targeted mRNA-LNPs to treat hematological malignancies.. Ex vivo chimeric antigen receptor (CAR) T cell therapy has proven successful in patients with B cell hematologic malignancies. However, current approaches are limited by the requirement for personal manufacturing processes and by barriers such as limited efficacy against solid tumors, treatmen…
Toxicology
CRS
Reported
Clinical
Safety signal
Reprogramming CD22 CAR-T cells in vivo using CD8-targeted mRNA-LNPs to treat hematological malignancies.. Ex vivo chimeric antigen receptor (CAR) T cell therapy has proven successful in patients with B cell hematologic malignancies. However, current approaches are limited by the requirement for personal manufacturing processes and by barriers such as limited efficacy against solid tumors, treatmen…
Clinical
Program phase
PRECLINICAL