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항목
CGTStandard DatabasestalePhase 1
CAR T-Cell Infusion (CAR T-Cell Infusion)
PersonGen BioTherapeutics (Suzhou)…·Leukemia
33 trials
Overview
Program
CAR T-Cell Infusion
Overview
Company
PersonGen BioTherapeutics (Suzhou) Co., Ltd.
Overview
Modality
CGT
Overview
Target
Leukemia
Overview
Indication
Relapsed Acute Lymphoblastic Leukemia (ALL)
Overview
Phase
PHASE_1
Overview
Status
RECRUITING
Overview
Content status
Standard Database
Overview
Data Confidence
Data Confidence · Medium
Overview
Development Signal
Development Signal · Watch
Overview
Approval status
Investigational
Toxicology
Major finding
Real-world use of polatuzumab vedotin combined with bendamustine and rituximab for patients with relapsed or refractory large B-cell lymphoma.. Polatuzumab vedotin combined with bendamustine and rituximab (Pola-BR) is a treatment option for relapsed/refractory diffuse large B-cell lymphoma (R/R DLBCL), particularly as bridging therapy before chimeric antigen receptor (CAR) T-cell infusion. However…
Toxicology
CRS
Reported
Clinical
Safety signal
Real-world use of polatuzumab vedotin combined with bendamustine and rituximab for patients with relapsed or refractory large B-cell lymphoma.. Polatuzumab vedotin combined with bendamustine and rituximab (Pola-BR) is a treatment option for relapsed/refractory diffuse large B-cell lymphoma (R/R DLBCL), particularly as bridging therapy before chimeric antigen receptor (CAR) T-cell infusion. However…
Clinical
Selected reported efficacy
ORR 67%
Clinical
Reported ORR
67%
Clinical
Result source
ClinicalTrials.gov NCT03704298
Clinical
Program phase
PHASE_1
Clinical
Trial ref
NCT03704298