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타깃 · 모달리티 · 임상 근거 · 비임상 맥락으로 최대 5개 프로그램을 나란히 비교합니다. · 다음 갱신 D-5 · 마지막 9월 2일

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프로그램 선택

API CSV15행 · 1개 프로그램
OverviewToxicologyClinical

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항목
CGTStandard DatabasestalePreclinical
CAR-CLD18 T cell (CAR-CLD18 T cell)
Kang YU·B Cell Lymphoma
1 trials
Overview
Program
CAR-CLD18 T cell
Overview
Company
Kang YU
Overview
Modality
CGT
Overview
Target
B Cell Lymphoma
Overview
Indication
B Cell Lymphoma; B Cell Leukemia
Overview
Phase
PRECLINICAL
Overview
Status
ACTIVE
Overview
Content status
Standard Database
Overview
Data Confidence
Data Confidence · Medium
Overview
Development Signal
Development Signal · Watch
Overview
Approval status
Investigational
Toxicology
Major finding
Macrophage ALDH2 drives immunotherapy resistance by silencing CXCL9 through metabolic-epigenetic crosstalk.. The metabolic basis of tumor-associated macrophages (TAMs)-driven immune checkpoint blockade (ICB) resistance remains poorly understood. Here, in patients with immunotherapy-resistant cancer, we identify significant enrichment of TAMs marked by elevated aldehyde dehydrogenase 2 (ALDH2) expr…
Toxicology
CRS
Reported
Clinical
Safety signal
Macrophage ALDH2 drives immunotherapy resistance by silencing CXCL9 through metabolic-epigenetic crosstalk.. The metabolic basis of tumor-associated macrophages (TAMs)-driven immune checkpoint blockade (ICB) resistance remains poorly understood. Here, in patients with immunotherapy-resistant cancer, we identify significant enrichment of TAMs marked by elevated aldehyde dehydrogenase 2 (ALDH2) expr…
Clinical
Program phase
PRECLINICAL