구조모아 (StructureMoa)항암 chemical structure spider web
방문타깃 · 모달리티 · 임상 근거 · 비임상 맥락으로 최대 5개 프로그램을 나란히 비교합니다. · 다음 갱신 D-5 · 마지막 9월 2일
현재 선택: 1개 · 임상 갱신 필요 1개
프로그램 상세에서 관심 등록 후 2개 이상 모으면 여기서 한 번에 비교할 수 있습니다.
표가 넓으면 좌우로 스크롤하세요. 핵심 비교 모드에서는 중요 항목만 표시됩니다.
| 항목 | |
|---|---|
Overview Program | BAY94-9343 (Expansion) |
Overview Company | Bayer |
Overview Modality | ADC |
Overview Target | Oncology |
Overview Indication | Oncology |
Overview Phase | PHASE_1 |
Overview Status | ACTIVE |
Overview Content status | Limited Data |
Overview Data Confidence | Data Confidence · Low |
Overview Development Signal | Development Signal · Watch |
Overview Approval status | Investigational |
Technology Linker | linker length, conferred markedly enhanced binding affinity and avidity compared to th |
MoA Mechanism | and potential as a precision immunomodulator that can selectively expand and reprogram T cells |
MoA Biomarker | biomarkers, neurophysiological function, bladder outcomes and spinal cord imaging metrics |
PK/PD Species | Mouse, Rat |
PK/PD Animal (cat.) | Mouse, Rat, In vitro |
PK/PD Experiment | pharmacokinetic |
Toxicology Species | Mouse, Rat |
Toxicology Animal (cat.) | Mouse, Rat, In vitro |
Toxicology Major finding | From Fenton reaction to ferroptosis: chemistry of metal complexes in regulated cell death by lipid peroxidation.. Ferroptosis is a regulated, iron-dependent form of cell death characterized by the unchecked peroxidation of polyunsaturated phospholipids and the collapse of cellular antioxidant defenses. Its therapeutic modulation has emerged as a promising strategy across a broad spectrum of diseas… |
Toxicology CRS | Reported |
Clinical Safety signal | From Fenton reaction to ferroptosis: chemistry of metal complexes in regulated cell death by lipid peroxidation.. Ferroptosis is a regulated, iron-dependent form of cell death characterized by the unchecked peroxidation of polyunsaturated phospholipids and the collapse of cellular antioxidant defenses. Its therapeutic modulation has emerged as a promising strategy across a broad spectrum of diseas… |
Clinical Selected reported efficacy | ORR 50% |
Clinical Reported ORR | 50% |
Clinical Reported PFS | 5.3 |
Clinical Reported OS | 8.7 |
Clinical Result source | ClinicalTrials.gov NCT04447027 |
Clinical Program phase | PHASE_1 |
Clinical Trial activity | No active/completed counts |
Clinical Trial ref | NCT04447027 |
타깃 · 모달리티 · 임상 근거 · 비임상 맥락으로 최대 5개 프로그램을 나란히 비교합니다. · 다음 갱신 D-5 · 마지막 9월 2일
현재 선택: 1개 · 임상 갱신 필요 1개
프로그램 상세에서 관심 등록 후 2개 이상 모으면 여기서 한 번에 비교할 수 있습니다.
표가 넓으면 좌우로 스크롤하세요. 핵심 비교 모드에서는 중요 항목만 표시됩니다.
| 항목 | |
|---|---|
Overview Program | BAY94-9343 (Expansion) |
Overview Company | Bayer |
Overview Modality | ADC |
Overview Target | Oncology |
Overview Indication | Oncology |
Overview Phase | PHASE_1 |
Overview Status | ACTIVE |
Overview Content status | Limited Data |
Overview Data Confidence | Data Confidence · Low |
Overview Development Signal | Development Signal · Watch |
Overview Approval status | Investigational |
Technology Linker | linker length, conferred markedly enhanced binding affinity and avidity compared to th |
MoA Mechanism | and potential as a precision immunomodulator that can selectively expand and reprogram T cells |
MoA Biomarker | biomarkers, neurophysiological function, bladder outcomes and spinal cord imaging metrics |
PK/PD Species | Mouse, Rat |
PK/PD Animal (cat.) | Mouse, Rat, In vitro |
PK/PD Experiment | pharmacokinetic |
Toxicology Species | Mouse, Rat |
Toxicology Animal (cat.) | Mouse, Rat, In vitro |
Toxicology Major finding | From Fenton reaction to ferroptosis: chemistry of metal complexes in regulated cell death by lipid peroxidation.. Ferroptosis is a regulated, iron-dependent form of cell death characterized by the unchecked peroxidation of polyunsaturated phospholipids and the collapse of cellular antioxidant defenses. Its therapeutic modulation has emerged as a promising strategy across a broad spectrum of diseas… |
Toxicology CRS | Reported |
Clinical Safety signal | From Fenton reaction to ferroptosis: chemistry of metal complexes in regulated cell death by lipid peroxidation.. Ferroptosis is a regulated, iron-dependent form of cell death characterized by the unchecked peroxidation of polyunsaturated phospholipids and the collapse of cellular antioxidant defenses. Its therapeutic modulation has emerged as a promising strategy across a broad spectrum of diseas… |
Clinical Selected reported efficacy | ORR 50% |
Clinical Reported ORR | 50% |
Clinical Reported PFS | 5.3 |
Clinical Reported OS | 8.7 |
Clinical Result source | ClinicalTrials.gov NCT04447027 |
Clinical Program phase | PHASE_1 |
Clinical Trial activity | No active/completed counts |
Clinical Trial ref | NCT04447027 |
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