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항목
AntibodyLimited DatastaleApproved
Product (Anti-Tumor Necrosis Factor Alpha Drug, Anti-Tumor Necrosis Factor Alpha Drug (Product))
R.Bos·Rheumatoid Arthritis
158 trials
Overview
Program
Anti-Tumor Necrosis Factor Alpha Drug (Product)
Overview
Company
R.Bos
Overview
Modality
ANTIBODY
Overview
Target
Rheumatoid Arthritis
Overview
Indication
Rheumatoid Arthritis
Overview
Phase
APPROVED
Overview
Status
RECRUITING
Overview
Content status
Limited Data
Overview
Data Confidence
Data Confidence · Low
Overview
Development Signal
Development Signal · Established
Overview
Approval status
Approved (flag incomplete)
MoA
Mechanism
target toxicity, as further supported by transcriptomic analysis revealing downregulation of fibrosis- and metabolism-related pathway
MoA
Biomarker
biomarkers, and well-designed clinical trials with vascular or cardiovascular endpoints are required before c
PK/PD
Species
Mouse
PK/PD
Animal (cat.)
Mouse, In vitro
PK/PD
Experiment
Pharmacokinetic
Toxicology
Species
Mouse
Toxicology
Animal (cat.)
Mouse
Toxicology
Major finding
thrombocytopenia and adverse events primarily limited to abdominal pain, nasopharyngitis, headac
Clinical
Safety signal
thrombocytopenia and adverse events primarily limited to abdominal pain, nasopharyngitis, headac
Clinical
Selected reported efficacy
Response 0.07447%
Clinical
Result source
ClinicalTrials.gov NCT01981473
Clinical
Program phase
APPROVED
Clinical
Trial activity
No active/completed counts
Clinical
Trial ref
NCT01981473
Preclinical
Animal (cat.)
Mouse