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항목
CGTStandard DatabasestalePhase 1
anti-CD19/CD22 CAR-T cells (anti-CD19/CD22 CAR-T cells)
Nanjing IASO Biotechnology Co., Lt…·CD19
28 trials
Overview
Program
anti-CD19/CD22 CAR-T cells
Overview
Company
Nanjing IASO Biotechnology Co., Ltd.
Overview
Modality
CGT
Overview
Target
CD19
Overview
Indication
MRD-positive; Acute Lymphoblastic Leukemia
Overview
Phase
PHASE_1
Overview
Status
ACTIVE
Overview
Content status
Standard Database
Overview
Data Confidence
Data Confidence · Medium
Overview
Development Signal
Development Signal · Watch
Overview
Approval status
Investigational
Toxicology
Major finding
Tandem CD19/CD22 CAR T-cells as potential therapy for children and young adults with high-risk r/r B-ALL.. Chimeric antigen receptor (CAR) T-cells targeting CD19 have shown impressive outcomes in refractory/relapsed B-cell acute lymphoblastic leukaemia (r/r B-ALL); however, frequent relapse demands multi-targeted approaches. We report Spanish clinical data on the safety and efficacy of tandem anti…
Toxicology
CRS
Reported
Clinical
Safety signal
Tandem CD19/CD22 CAR T-cells as potential therapy for children and young adults with high-risk r/r B-ALL.. Chimeric antigen receptor (CAR) T-cells targeting CD19 have shown impressive outcomes in refractory/relapsed B-cell acute lymphoblastic leukaemia (r/r B-ALL); however, frequent relapse demands multi-targeted approaches. We report Spanish clinical data on the safety and efficacy of tandem anti…
Clinical
Selected reported efficacy
ORR 1%
Clinical
Reported ORR
1%
Clinical
Result source
ClinicalTrials.gov NCT03287817
Clinical
Program phase
PHASE_1
Clinical
Trial ref
NCT03287817