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API CSV24행 · 1개 프로그램
OverviewTechnologyMoAPK/PDToxicologyClinicalPreclinical

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항목
CGTStandard DatabasestalePhase 1
Allogeneic CART-NKG2D cells (Allogeneic CART-NKG2D cells)
Instituto de Investigación Hospita…·Precursor Cell Lymphoblastic Leuke…
1 trials
Overview
Program
Allogeneic CART-NKG2D cells
Overview
Company
Instituto de Investigación Hospital Universitario La Paz
Overview
Modality
CGT
Overview
Target
Precursor Cell Lymphoblastic Leukemia-Ly
Overview
Indication
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Overview
Phase
PHASE_1
Overview
Status
RECRUITING
Overview
Content status
Standard Database
Overview
Data Confidence
Data Confidence · Medium
Overview
Development Signal
Development Signal · Watch
Overview
Approval status
Investigational
Technology
Vector
retroviral vector that enhances NK cell activation, recruitment, survival, and metabolic f
MoA
Mechanism
ADCC) and antibody-dependent cellular phagocytosis (ADCP), in vitro and in vivo
MoA
Biomarker
biomarkers and therapeutic delivery agents in precision medicine and personalized healthcare
PK/PD
Species
Cynomolgus monkey
PK/PD
Animal (cat.)
NHP, In vitro
PK/PD
Experiment
pharmacokinetic
Toxicology
Species
Cynomolgus monkey
Toxicology
Animal (cat.)
NHP, In vitro
Toxicology
Major finding
thrombocytopenia (n=18 (39
Toxicology
CRS
Reported
Clinical
Safety signal
thrombocytopenia (n=18 (39
Clinical
Program phase
PHASE_1
Preclinical
Animal (cat.)
NHP