구조모아 (StructureMoa)항암 chemical structure spider web
방문타깃 · 모달리티 · 임상 근거 · 비임상 맥락으로 최대 5개 프로그램을 나란히 비교합니다. · 다음 갱신 D-6 · 마지막 9월 2일
현재 선택: 1개 · 임상 갱신 필요 1개
프로그램 상세에서 관심 등록 후 2개 이상 모으면 여기서 한 번에 비교할 수 있습니다.
표가 넓으면 좌우로 스크롤하세요. 핵심 비교 모드에서는 중요 항목만 표시됩니다.
| 항목 | |
|---|---|
Overview Program | Adriamycin |
Overview Company | Palleos Healthcare GmbH |
Overview Modality | ADC |
Overview Target | Hodgkin Lymphoma |
Overview Indication | Hodgkin Lymphoma |
Overview Phase | PHASE_2 |
Overview Status | ACTIVE |
Overview Content status | Limited Data |
Overview Data Confidence | Data Confidence · Low |
Overview Development Signal | Development Signal · Emerging |
Overview Approval status | Investigational |
Technology Payload | vedotin, vinblastine, and dacarbazine) |
Technology Linker | linker provides the conformational flexibility required to reproduce key interactions |
MoA Mechanism | target multiple pathways, including adenosine triphosphate(ATP) binding, endoplasmic reticulum function, the mitogen-activated protein kinase(MAPK) pathway |
MoA Biomarker | biomarkers in serum, besides histopathological alterations in rats' liver and kidney |
PK/PD Half-life | 78.4 days |
PK/PD Species | Mouse, Rat |
PK/PD Animal (cat.) | Mouse, Rat, In vitro |
PK/PD Experiment | pharmacokinetic |
Toxicology Species | Mouse, Rat |
Toxicology Animal (cat.) | Mouse, Rat, In vitro |
Toxicology Major finding | thrombocytopenia who was diagnosed with DC based on clinical features and genetic testing |
Clinical Safety signal | thrombocytopenia who was diagnosed with DC based on clinical features and genetic testing |
Clinical Selected reported efficacy | ORR 95% |
Clinical Reported ORR | 95.0% |
Clinical Result source | ClinicalTrials.gov NCT03677141 |
Clinical Program phase | PHASE_2 |
Clinical Trial activity | No active/completed counts |
Clinical Trial ref | NCT03677141 |
타깃 · 모달리티 · 임상 근거 · 비임상 맥락으로 최대 5개 프로그램을 나란히 비교합니다. · 다음 갱신 D-6 · 마지막 9월 2일
현재 선택: 1개 · 임상 갱신 필요 1개
프로그램 상세에서 관심 등록 후 2개 이상 모으면 여기서 한 번에 비교할 수 있습니다.
표가 넓으면 좌우로 스크롤하세요. 핵심 비교 모드에서는 중요 항목만 표시됩니다.
| 항목 | |
|---|---|
Overview Program | Adriamycin |
Overview Company | Palleos Healthcare GmbH |
Overview Modality | ADC |
Overview Target | Hodgkin Lymphoma |
Overview Indication | Hodgkin Lymphoma |
Overview Phase | PHASE_2 |
Overview Status | ACTIVE |
Overview Content status | Limited Data |
Overview Data Confidence | Data Confidence · Low |
Overview Development Signal | Development Signal · Emerging |
Overview Approval status | Investigational |
Technology Payload | vedotin, vinblastine, and dacarbazine) |
Technology Linker | linker provides the conformational flexibility required to reproduce key interactions |
MoA Mechanism | target multiple pathways, including adenosine triphosphate(ATP) binding, endoplasmic reticulum function, the mitogen-activated protein kinase(MAPK) pathway |
MoA Biomarker | biomarkers in serum, besides histopathological alterations in rats' liver and kidney |
PK/PD Half-life | 78.4 days |
PK/PD Species | Mouse, Rat |
PK/PD Animal (cat.) | Mouse, Rat, In vitro |
PK/PD Experiment | pharmacokinetic |
Toxicology Species | Mouse, Rat |
Toxicology Animal (cat.) | Mouse, Rat, In vitro |
Toxicology Major finding | thrombocytopenia who was diagnosed with DC based on clinical features and genetic testing |
Clinical Safety signal | thrombocytopenia who was diagnosed with DC based on clinical features and genetic testing |
Clinical Selected reported efficacy | ORR 95% |
Clinical Reported ORR | 95.0% |
Clinical Result source | ClinicalTrials.gov NCT03677141 |
Clinical Program phase | PHASE_2 |
Clinical Trial activity | No active/completed counts |
Clinical Trial ref | NCT03677141 |
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