타깃 · 모달리티 · 임상 근거 · 비임상 맥락으로 최대 5개 프로그램을 나란히 비교합니다. · 자동 수집 갱신 권장 · 9월 2일
현재 선택: 2개 · 임상 갱신 필요 2개 · Data Tier에서 열림
프로그램 상세에서 관심 등록 후 2개 이상 모으면 여기서 한 번에 비교할 수 있습니다.
표가 넓으면 좌우로 스크롤하세요. 핵심 비교 모드에서는 중요 항목만 표시됩니다.
| 항목 | mirvetuximab soravtansine-gynx (Elahere, IMGN853, mirvetuximab-soravtansine-gynx) AbbVie / ImmunoGen·FRα (folate receptor alpha) 32 trials | |
|---|---|---|
Overview Program | Polatuzumab Vedotin | Elahere (mirvetuximab soravtansine-gynx) |
Overview Company | Roche / Genentech | AbbVie / ImmunoGen |
Overview Modality | ADC | ADC |
Overview Target | FRα | FRα (folate receptor alpha) |
Overview Indication | Large B-Cell Lymphoma | FRα-positive platinum-resistant ovarian, fallopian tube, or primary peritoneal cancer |
Overview Phase | PHASE_3 | APPROVED |
Overview Status | RECRUITING | APPROVED |
Overview Content status | Curated Core | Curated Core |
Overview Data Confidence | Editorial scope · Curated Core | Editorial scope · Curated Core |
Overview Development Signal | Development Signal · Established | Development Signal · Established |
Overview Approval status | FDA approved | FDA approved |
Positioning Key differentiator | unique toxicities related to the antigen target, linker, or payload that have limited their development | FRα is overexpressed in ovarian cancer but sparse in normal tissue, and the label requires IHC-confirmed expression. |
Positioning Known limitation | resistance to POLA in vivo | FRα downregulation and multidrug-resistance transporter upregulation. |
Positioning Development positioning | — | 2L–4L platinum-resistant |
Technology Payload | vedotin, rituximab, cyclophosphamide, doxorubic | DM4 (maytansinoid, tubulin inhibitor) |
Technology Linker | linker, or payload that have limited their development | Cleavable sulfo-SPDB disulfide, DAR ~3.5 |
Technology DAR | — | DAR 3.5 |
MoA Mechanism | targeting specific cell surface antigens, many ADCs have also been associated with unique toxicities related to the antigen | Binds FRα, internalizes via receptor-mediated endocytosis, and releases DM4 after disulfide reduction; tubulin disruption causes mitotic arrest, with lipophilic S-methyl-DM4 giving bystander activity. |
MoA Biomarker | CD20 expression | FRα IHC (VENTANA FOLR1 RxDx), PS2+ scoring with ≥75% of tumor cells staining. |
Toxicology Species | Cynomolgus monkey, Mouse, Rat | Rat |
Toxicology Animal (cat.) | Mouse, Rat, NHP | — |
Toxicology Major finding | Hepatotoxicity: Monitor liver enzymes and bilirubin | Boxed warning for ocular toxicity — keratopathy, blurred vision, and dry eye. Peripheral neuropathy, nausea, and fatigue are also common. |
Toxicology CRS | — | N/A |
Clinical Safety signal | Hepatotoxicity: Monitor liver enzymes and bilirubin | Boxed warning for ocular toxicity — keratopathy, blurred vision, and dry eye. Peripheral neuropathy, nausea, and fatigue are also common. |
Clinical Selected reported efficacy | — | ORR 42% |
Clinical Reported ORR | — | 42% vs 16% (chemotherapy; rounded in NCI report) |
Clinical Reported PFS | — | 5.6 months vs 4.0 months (chemotherapy) |
Clinical Reported OS | — | 16.5 months vs 12.8 months (chemotherapy) |
Clinical Result source | — | NCI approval analysis 2024 — MIRASOL (NCT04209855) |
Clinical Program phase | PHASE_3 | APPROVED |
Clinical Trial activity | No active/completed counts | No active/completed counts |
Clinical Trial ref | — | NCT04209855 |
Preclinical Animal (cat.) | Rat | — |
타깃 · 모달리티 · 임상 근거 · 비임상 맥락으로 최대 5개 프로그램을 나란히 비교합니다. · 자동 수집 갱신 권장 · 9월 2일
현재 선택: 2개 · 임상 갱신 필요 2개 · Data Tier에서 열림
프로그램 상세에서 관심 등록 후 2개 이상 모으면 여기서 한 번에 비교할 수 있습니다.
표가 넓으면 좌우로 스크롤하세요. 핵심 비교 모드에서는 중요 항목만 표시됩니다.
| 항목 | mirvetuximab soravtansine-gynx (Elahere, IMGN853, mirvetuximab-soravtansine-gynx) AbbVie / ImmunoGen·FRα (folate receptor alpha) 32 trials | |
|---|---|---|
Overview Program | Polatuzumab Vedotin | Elahere (mirvetuximab soravtansine-gynx) |
Overview Company | Roche / Genentech | AbbVie / ImmunoGen |
Overview Modality | ADC | ADC |
Overview Target | FRα | FRα (folate receptor alpha) |
Overview Indication | Large B-Cell Lymphoma | FRα-positive platinum-resistant ovarian, fallopian tube, or primary peritoneal cancer |
Overview Phase | PHASE_3 | APPROVED |
Overview Status | RECRUITING | APPROVED |
Overview Content status | Curated Core | Curated Core |
Overview Data Confidence | Editorial scope · Curated Core | Editorial scope · Curated Core |
Overview Development Signal | Development Signal · Established | Development Signal · Established |
Overview Approval status | FDA approved | FDA approved |
Positioning Key differentiator | unique toxicities related to the antigen target, linker, or payload that have limited their development | FRα is overexpressed in ovarian cancer but sparse in normal tissue, and the label requires IHC-confirmed expression. |
Positioning Known limitation | resistance to POLA in vivo | FRα downregulation and multidrug-resistance transporter upregulation. |
Positioning Development positioning | — | 2L–4L platinum-resistant |
Technology Payload | vedotin, rituximab, cyclophosphamide, doxorubic | DM4 (maytansinoid, tubulin inhibitor) |
Technology Linker | linker, or payload that have limited their development | Cleavable sulfo-SPDB disulfide, DAR ~3.5 |
Technology DAR | — | DAR 3.5 |
MoA Mechanism | targeting specific cell surface antigens, many ADCs have also been associated with unique toxicities related to the antigen | Binds FRα, internalizes via receptor-mediated endocytosis, and releases DM4 after disulfide reduction; tubulin disruption causes mitotic arrest, with lipophilic S-methyl-DM4 giving bystander activity. |
MoA Biomarker | CD20 expression | FRα IHC (VENTANA FOLR1 RxDx), PS2+ scoring with ≥75% of tumor cells staining. |
Toxicology Species | Cynomolgus monkey, Mouse, Rat | Rat |
Toxicology Animal (cat.) | Mouse, Rat, NHP | — |
Toxicology Major finding | Hepatotoxicity: Monitor liver enzymes and bilirubin | Boxed warning for ocular toxicity — keratopathy, blurred vision, and dry eye. Peripheral neuropathy, nausea, and fatigue are also common. |
Toxicology CRS | — | N/A |
Clinical Safety signal | Hepatotoxicity: Monitor liver enzymes and bilirubin | Boxed warning for ocular toxicity — keratopathy, blurred vision, and dry eye. Peripheral neuropathy, nausea, and fatigue are also common. |
Clinical Selected reported efficacy | — | ORR 42% |
Clinical Reported ORR | — | 42% vs 16% (chemotherapy; rounded in NCI report) |
Clinical Reported PFS | — | 5.6 months vs 4.0 months (chemotherapy) |
Clinical Reported OS | — | 16.5 months vs 12.8 months (chemotherapy) |
Clinical Result source | — | NCI approval analysis 2024 — MIRASOL (NCT04209855) |
Clinical Program phase | PHASE_3 | APPROVED |
Clinical Trial activity | No active/completed counts | No active/completed counts |
Clinical Trial ref | — | NCT04209855 |
Preclinical Animal (cat.) | Rat | — |
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