구조모아 (StructureMoa)항암 chemical structure spider web
방문타깃 · 모달리티 · 임상 근거 · 비임상 맥락으로 최대 5개 프로그램을 나란히 비교합니다. · 다음 갱신 D-6 · 마지막 9월 2일
현재 선택: 2개 · 임상 갱신 필요 2개
프로그램 상세에서 관심 등록 후 2개 이상 모으면 여기서 한 번에 비교할 수 있습니다.
표가 넓으면 좌우로 스크롤하세요. 핵심 비교 모드에서는 중요 항목만 표시됩니다.
| 항목 | Platinum Based Chemotherapy (Platinum Based Chemotherapy) Merck Sharp & Dohme LLC·Ovarian Cancer 128 trials·t½ 12.73 h | |
|---|---|---|
Overview Program | Platinum Based Chemotherapy | HWK-007 |
Overview Company | Merck Sharp & Dohme LLC | Whitehawk Therapeutics, Inc. |
Overview Modality | ADC | ADC |
Overview Target | Ovarian Cancer | EGFR |
Overview Indication | Nonsquamous Non-small Cell Lung Cancer; EGFR L858R | Endometrial Cancer; Ovarian Cancer |
Overview Phase | PHASE_3 | PHASE_1 |
Overview Status | RECRUITING | RECRUITING |
Overview Content status | Limited Data | Limited Data |
Overview Data Confidence | Data Confidence · Low | Data Confidence · Low |
Overview Development Signal | Development Signal · Emerging | Development Signal · Watch |
Overview Approval status | Investigational | Investigational |
Technology Payload | vedotin (ARON-2EV study) | — |
MoA Mechanism | targeting oxidative stress, hypoxia, persistent DNA damage, immune signaling | — |
MoA Biomarker | biomarker-embedded clinical trials, molecular subtype-stratified patient selection, and rigorous evaluation o | — |
PK/PD Half-life | 12.73 h | — |
PK/PD Species | Mouse | — |
PK/PD Animal (cat.) | Mouse, In vitro | — |
PK/PD Experiment | PD | — |
Toxicology Species | Mouse | — |
Toxicology Animal (cat.) | Mouse, In vitro | — |
Toxicology Major finding | Thrombocytopenia was mainly related to niraparib treatment, and anemia was mainly related to ola | — |
Clinical Safety signal | Thrombocytopenia was mainly related to niraparib treatment, and anemia was mainly related to ola | — |
Clinical Selected reported efficacy | ORR 66% | — |
Clinical Reported ORR | 66% | — |
Clinical Result source | ClinicalTrials.gov NCT03663166 | — |
Clinical Program phase | PHASE_3 | PHASE_1 |
Clinical Trial activity | No active/completed counts | — |
Clinical Trial ref | NCT03663166 | — |
타깃 · 모달리티 · 임상 근거 · 비임상 맥락으로 최대 5개 프로그램을 나란히 비교합니다. · 다음 갱신 D-6 · 마지막 9월 2일
현재 선택: 2개 · 임상 갱신 필요 2개
프로그램 상세에서 관심 등록 후 2개 이상 모으면 여기서 한 번에 비교할 수 있습니다.
표가 넓으면 좌우로 스크롤하세요. 핵심 비교 모드에서는 중요 항목만 표시됩니다.
| 항목 | Platinum Based Chemotherapy (Platinum Based Chemotherapy) Merck Sharp & Dohme LLC·Ovarian Cancer 128 trials·t½ 12.73 h | |
|---|---|---|
Overview Program | Platinum Based Chemotherapy | HWK-007 |
Overview Company | Merck Sharp & Dohme LLC | Whitehawk Therapeutics, Inc. |
Overview Modality | ADC | ADC |
Overview Target | Ovarian Cancer | EGFR |
Overview Indication | Nonsquamous Non-small Cell Lung Cancer; EGFR L858R | Endometrial Cancer; Ovarian Cancer |
Overview Phase | PHASE_3 | PHASE_1 |
Overview Status | RECRUITING | RECRUITING |
Overview Content status | Limited Data | Limited Data |
Overview Data Confidence | Data Confidence · Low | Data Confidence · Low |
Overview Development Signal | Development Signal · Emerging | Development Signal · Watch |
Overview Approval status | Investigational | Investigational |
Technology Payload | vedotin (ARON-2EV study) | — |
MoA Mechanism | targeting oxidative stress, hypoxia, persistent DNA damage, immune signaling | — |
MoA Biomarker | biomarker-embedded clinical trials, molecular subtype-stratified patient selection, and rigorous evaluation o | — |
PK/PD Half-life | 12.73 h | — |
PK/PD Species | Mouse | — |
PK/PD Animal (cat.) | Mouse, In vitro | — |
PK/PD Experiment | PD | — |
Toxicology Species | Mouse | — |
Toxicology Animal (cat.) | Mouse, In vitro | — |
Toxicology Major finding | Thrombocytopenia was mainly related to niraparib treatment, and anemia was mainly related to ola | — |
Clinical Safety signal | Thrombocytopenia was mainly related to niraparib treatment, and anemia was mainly related to ola | — |
Clinical Selected reported efficacy | ORR 66% | — |
Clinical Reported ORR | 66% | — |
Clinical Result source | ClinicalTrials.gov NCT03663166 | — |
Clinical Program phase | PHASE_3 | PHASE_1 |
Clinical Trial activity | No active/completed counts | — |
Clinical Trial ref | NCT03663166 | — |
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