구조모아 (StructureMoa)항암 chemical structure spider web
방문타깃 · 모달리티 · 임상 근거 · 비임상 맥락으로 최대 5개 프로그램을 나란히 비교합니다. · 다음 갱신 D-5 · 마지막 9월 2일
현재 선택: 2개 · 임상 갱신 필요 2개
프로그램 상세에서 관심 등록 후 2개 이상 모으면 여기서 한 번에 비교할 수 있습니다.
표가 넓으면 좌우로 스크롤하세요. 핵심 비교 모드에서는 중요 항목만 표시됩니다.
| 항목 | Anti-PD-1 Monoclonal Antibody REGN2810 (Anti-PD-1 Monoclonal Antibody REGN2810) Sidney Kimmel Comprehensive Cancer…·PD-1 1 trials | |
|---|---|---|
Overview Program | PD1-PSMA-CART cells | Anti-PD-1 Monoclonal Antibody REGN2810 |
Overview Company | Bioray Laboratories | Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University |
Overview Modality | CGT | ANTIBODY |
Overview Target | PSMA | PD-1 |
Overview Indication | Castrate-Resistant Prostate Cancer | Stage III Prostate Cancer; Stage IIIA Prostate Cancer |
Overview Phase | PHASE_1 | PHASE_1 |
Overview Status | ACTIVE | DISCONTINUED |
Overview Content status | Standard Database | Limited Data |
Overview Data Confidence | Data Confidence · Medium | Data Confidence · Low |
Overview Development Signal | Development Signal · Watch | Development Signal · Watch |
Overview Approval status | Investigational | Investigational |
Toxicology Major finding | De novo design of miniproteins targeting GPCRs.. G protein-coupled receptors (GPCRs) play key roles in physiology and are central targets for drug discovery and development 1,2 , but the design of protein agonists and antagonists has been challenging as GPCRs are integral membrane proteins and conformationally dynamic 3-6 . Here we describe computational de novo design methods and a high-throughpu… | Efficacy and Safety of Cosibelimab for Advanced Cutaneous Squamous Cell Carcinoma: An Expert Consensus Panel.. Cutaneous squamous cell carcinoma (cSCC) represents a significant clinical challenge in patients with locally advanced (laCSCC) or metastatic (mCSCC) disease who are not candidates for surgery or radiation. In addition to PD-1 inhibitors, pembrolizumab and cemiplimab, cosibelimab, a PD-L1… |
Toxicology CRS | Reported | — |
Clinical Safety signal | De novo design of miniproteins targeting GPCRs.. G protein-coupled receptors (GPCRs) play key roles in physiology and are central targets for drug discovery and development 1,2 , but the design of protein agonists and antagonists has been challenging as GPCRs are integral membrane proteins and conformationally dynamic 3-6 . Here we describe computational de novo design methods and a high-throughpu… | Efficacy and Safety of Cosibelimab for Advanced Cutaneous Squamous Cell Carcinoma: An Expert Consensus Panel.. Cutaneous squamous cell carcinoma (cSCC) represents a significant clinical challenge in patients with locally advanced (laCSCC) or metastatic (mCSCC) disease who are not candidates for surgery or radiation. In addition to PD-1 inhibitors, pembrolizumab and cemiplimab, cosibelimab, a PD-L1… |
Clinical Selected reported efficacy | — | ORR 52% |
Clinical Reported ORR | — | 52% |
Clinical Result source | — | ClinicalTrials.gov NCT03257267 |
Clinical Program phase | PHASE_1 | PHASE_1 |
Clinical Trial ref | — | NCT03257267 |
타깃 · 모달리티 · 임상 근거 · 비임상 맥락으로 최대 5개 프로그램을 나란히 비교합니다. · 다음 갱신 D-5 · 마지막 9월 2일
현재 선택: 2개 · 임상 갱신 필요 2개
프로그램 상세에서 관심 등록 후 2개 이상 모으면 여기서 한 번에 비교할 수 있습니다.
표가 넓으면 좌우로 스크롤하세요. 핵심 비교 모드에서는 중요 항목만 표시됩니다.
| 항목 | Anti-PD-1 Monoclonal Antibody REGN2810 (Anti-PD-1 Monoclonal Antibody REGN2810) Sidney Kimmel Comprehensive Cancer…·PD-1 1 trials | |
|---|---|---|
Overview Program | PD1-PSMA-CART cells | Anti-PD-1 Monoclonal Antibody REGN2810 |
Overview Company | Bioray Laboratories | Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University |
Overview Modality | CGT | ANTIBODY |
Overview Target | PSMA | PD-1 |
Overview Indication | Castrate-Resistant Prostate Cancer | Stage III Prostate Cancer; Stage IIIA Prostate Cancer |
Overview Phase | PHASE_1 | PHASE_1 |
Overview Status | ACTIVE | DISCONTINUED |
Overview Content status | Standard Database | Limited Data |
Overview Data Confidence | Data Confidence · Medium | Data Confidence · Low |
Overview Development Signal | Development Signal · Watch | Development Signal · Watch |
Overview Approval status | Investigational | Investigational |
Toxicology Major finding | De novo design of miniproteins targeting GPCRs.. G protein-coupled receptors (GPCRs) play key roles in physiology and are central targets for drug discovery and development 1,2 , but the design of protein agonists and antagonists has been challenging as GPCRs are integral membrane proteins and conformationally dynamic 3-6 . Here we describe computational de novo design methods and a high-throughpu… | Efficacy and Safety of Cosibelimab for Advanced Cutaneous Squamous Cell Carcinoma: An Expert Consensus Panel.. Cutaneous squamous cell carcinoma (cSCC) represents a significant clinical challenge in patients with locally advanced (laCSCC) or metastatic (mCSCC) disease who are not candidates for surgery or radiation. In addition to PD-1 inhibitors, pembrolizumab and cemiplimab, cosibelimab, a PD-L1… |
Toxicology CRS | Reported | — |
Clinical Safety signal | De novo design of miniproteins targeting GPCRs.. G protein-coupled receptors (GPCRs) play key roles in physiology and are central targets for drug discovery and development 1,2 , but the design of protein agonists and antagonists has been challenging as GPCRs are integral membrane proteins and conformationally dynamic 3-6 . Here we describe computational de novo design methods and a high-throughpu… | Efficacy and Safety of Cosibelimab for Advanced Cutaneous Squamous Cell Carcinoma: An Expert Consensus Panel.. Cutaneous squamous cell carcinoma (cSCC) represents a significant clinical challenge in patients with locally advanced (laCSCC) or metastatic (mCSCC) disease who are not candidates for surgery or radiation. In addition to PD-1 inhibitors, pembrolizumab and cemiplimab, cosibelimab, a PD-L1… |
Clinical Selected reported efficacy | — | ORR 52% |
Clinical Reported ORR | — | 52% |
Clinical Result source | — | ClinicalTrials.gov NCT03257267 |
Clinical Program phase | PHASE_1 | PHASE_1 |
Clinical Trial ref | — | NCT03257267 |
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