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항목
CGTStandard DatabasestalePhase 2
Talimogene Laherparepvec (Talimogene Laherparepvec)
SOLTI Breast Cancer Research Group·Melanoma
48 trials
Overview
Program
Talimogene Laherparepvec
Overview
Company
SOLTI Breast Cancer Research Group
Overview
Modality
CGT
Overview
Target
Melanoma
Overview
Indication
Peritoneal Surface Malignancy
Overview
Phase
PHASE_2
Overview
Status
DISCONTINUED
Overview
Content status
Standard Database
Overview
Data Confidence
Data Confidence · Medium
Overview
Development Signal
Development Signal · Emerging
Overview
Approval status
Investigational
MoA
Mechanism
, and emerging therapeutic potential of oncolytic viruses (OVs) in the management of HNSCC, with an emphasis on ongoing trials, approved agents, and future directions
MoA
Biomarker
HER2-negative breast cancer follow
PK/PD
Species
Mouse
PK/PD
Animal (cat.)
Mouse
PK/PD
Experiment
PD
Toxicology
Species
Mouse
Toxicology
Animal (cat.)
Mouse
Toxicology
Major finding
Re-evaluating melanoma treatment: a comparative look at herpes simplex virus and coxsackievirus oncolytic therapies in advanced melanoma: a meta-analysis of clinical trials.. Advanced melanoma, a highly lethal skin cancer, causes most skin cancer-related deaths. Oncolytic monotherapy or alongside immune checkpoint inhibitors (ICIs) is emerging as a promising treatment. Evaluating the therapeutic b…
Clinical
Safety signal
Re-evaluating melanoma treatment: a comparative look at herpes simplex virus and coxsackievirus oncolytic therapies in advanced melanoma: a meta-analysis of clinical trials.. Advanced melanoma, a highly lethal skin cancer, causes most skin cancer-related deaths. Oncolytic monotherapy or alongside immune checkpoint inhibitors (ICIs) is emerging as a promising treatment. Evaluating the therapeutic b…
Clinical
Selected reported efficacy
ORR 100%
Clinical
Reported ORR
100%
Clinical
Result source
ClinicalTrials.gov NCT03714828
Clinical
Program phase
PHASE_2
Clinical
Trial ref
NCT03714828