타깃 · 모달리티 · 임상 근거 · 비임상 맥락으로 최대 5개 프로그램을 나란히 비교합니다. · 자동 수집 갱신 권장 · 9월 2일
현재 선택: 1개 · 임상 갱신 필요 1개
프로그램 상세에서 관심 등록 후 2개 이상 모으면 여기서 한 번에 비교할 수 있습니다.
표가 넓으면 좌우로 스크롤하세요. 핵심 비교 모드에서는 중요 항목만 표시됩니다.
| 항목 | |
|---|---|
Overview Program | Repatha (evolocumab) |
Overview Company | Amgen |
Overview Modality | ANTIBODY |
Overview Target | PCSK9 |
Overview Indication | Hyperlipidemia, ASCVD risk reduction, HeFH, HoFH |
Overview Phase | APPROVED |
Overview Status | APPROVED |
Overview Content status | Curated Core |
Overview Data Confidence | Editorial scope · Curated Core |
Overview Development Signal | Development Signal · Established |
Overview Approval status | FDA approved |
Positioning Key differentiator | High LDL-C lowering without statin myalgia; autoinjector pen |
Positioning Known limitation | Statin non-adherence; rare anti-drug antibodies |
Positioning Development positioning | Add-on to statin ± ezetimibe |
MoA Mechanism | Evolocumab binds PCSK9, preventing PCSK9-mediated LDL receptor degradation on hepatocytes, increasing LDLR recycling and hepatic LDL-C clearance. |
MoA Biomarker | LDL-C, ApoB, non-HDL-C; Lp(a) modest reduction. |
Toxicology Species | Cynomolgus monkey, Hamster |
Toxicology Animal (cat.) | NHP |
Toxicology Major finding | No major organ toxicity; injection-site reactions |
Toxicology CRS | N/A |
Clinical Safety signal | No major organ toxicity; injection-site reactions |
Clinical Program phase | APPROVED |
Clinical Trial activity | No active/completed counts |
Preclinical Animal (cat.) | Mouse, In vitro |
타깃 · 모달리티 · 임상 근거 · 비임상 맥락으로 최대 5개 프로그램을 나란히 비교합니다. · 자동 수집 갱신 권장 · 9월 2일
현재 선택: 1개 · 임상 갱신 필요 1개
프로그램 상세에서 관심 등록 후 2개 이상 모으면 여기서 한 번에 비교할 수 있습니다.
표가 넓으면 좌우로 스크롤하세요. 핵심 비교 모드에서는 중요 항목만 표시됩니다.
| 항목 | |
|---|---|
Overview Program | Repatha (evolocumab) |
Overview Company | Amgen |
Overview Modality | ANTIBODY |
Overview Target | PCSK9 |
Overview Indication | Hyperlipidemia, ASCVD risk reduction, HeFH, HoFH |
Overview Phase | APPROVED |
Overview Status | APPROVED |
Overview Content status | Curated Core |
Overview Data Confidence | Editorial scope · Curated Core |
Overview Development Signal | Development Signal · Established |
Overview Approval status | FDA approved |
Positioning Key differentiator | High LDL-C lowering without statin myalgia; autoinjector pen |
Positioning Known limitation | Statin non-adherence; rare anti-drug antibodies |
Positioning Development positioning | Add-on to statin ± ezetimibe |
MoA Mechanism | Evolocumab binds PCSK9, preventing PCSK9-mediated LDL receptor degradation on hepatocytes, increasing LDLR recycling and hepatic LDL-C clearance. |
MoA Biomarker | LDL-C, ApoB, non-HDL-C; Lp(a) modest reduction. |
Toxicology Species | Cynomolgus monkey, Hamster |
Toxicology Animal (cat.) | NHP |
Toxicology Major finding | No major organ toxicity; injection-site reactions |
Toxicology CRS | N/A |
Clinical Safety signal | No major organ toxicity; injection-site reactions |
Clinical Program phase | APPROVED |
Clinical Trial activity | No active/completed counts |
Preclinical Animal (cat.) | Mouse, In vitro |
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