구조모아 (StructureMoa)항암 chemical structure spider web
방문프로그램 상세에서 관심 등록 후 2개 이상 모으면 여기서 한 번에 비교할 수 있습니다.
표가 넓으면 좌우로 스크롤하세요. 핵심 비교 모드에서는 중요 항목만 표시됩니다.
| 항목 | |
|---|---|
Overview Program | Opdivo (nivolumab) |
Overview Company | Bristol Myers Squibb |
Overview Modality | ANTIBODY |
Overview Target | PD-1 |
Overview Indication | Melanoma, NSCLC, RCC, HCC, MSI-H tumors, and others |
Overview Phase | APPROVED |
Overview Status | APPROVED |
Overview Content status | Curated Core |
Overview Data Confidence | Data Confidence · High |
Overview Development Signal | Development Signal · Established |
Overview Approval status | FDA approved |
Positioning Key differentiator | novel approach to enhance antitumor therapy using aPD1 and aCTLA-4 |
Positioning Known limitation | Loss of MHC-I/antigen presentation, β2M/JAK mutations, TIM-3/LAG-3 upregulation. |
MoA Mechanism | Nivolumab is a human IgG4 monoclonal antibody that binds the PD-1 receptor on T cells, blocking interaction with PD-L1 and PD-L2 and releasing PD-1 pathway-mediated inhibition of antitumor immune responses. |
MoA Biomarker | PD-1 with slow dissociation and preferential binding in TME-mimicking low |
PK/PD Half-life | 25 h |
PK/PD Species | Mouse, Objective response, duration of response, exploratory ctDNA clearance |
PK/PD Animal (cat.) | Mouse |
PK/PD Experiment | PD |
Toxicology Species | Cynomolgus monkey, Macaque, Mouse |
Toxicology Animal (cat.) | NHP |
Toxicology Major finding | Immune-related adverse reactions: pneumonitis, colitis, hepatitis, hypophysitis, thyroid disorders, nephritis, rash. |
Toxicology CRS | N/A (checkpoint inhibitor) |
Clinical Safety signal | Immune-related adverse reactions: pneumonitis, colitis, hepatitis, hypophysitis, thyroid disorders, nephritis, rash. |
Clinical Selected reported efficacy | ORR 100% |
Clinical Reported ORR | 100% |
Clinical Result source | ClinicalTrials.gov NCT03267498 |
Clinical Program phase | APPROVED |
Clinical Trial activity | No active/completed counts |
Clinical Trial ref | NCT03267498 |
프로그램 상세에서 관심 등록 후 2개 이상 모으면 여기서 한 번에 비교할 수 있습니다.
표가 넓으면 좌우로 스크롤하세요. 핵심 비교 모드에서는 중요 항목만 표시됩니다.
| 항목 | |
|---|---|
Overview Program | Opdivo (nivolumab) |
Overview Company | Bristol Myers Squibb |
Overview Modality | ANTIBODY |
Overview Target | PD-1 |
Overview Indication | Melanoma, NSCLC, RCC, HCC, MSI-H tumors, and others |
Overview Phase | APPROVED |
Overview Status | APPROVED |
Overview Content status | Curated Core |
Overview Data Confidence | Data Confidence · High |
Overview Development Signal | Development Signal · Established |
Overview Approval status | FDA approved |
Positioning Key differentiator | novel approach to enhance antitumor therapy using aPD1 and aCTLA-4 |
Positioning Known limitation | Loss of MHC-I/antigen presentation, β2M/JAK mutations, TIM-3/LAG-3 upregulation. |
MoA Mechanism | Nivolumab is a human IgG4 monoclonal antibody that binds the PD-1 receptor on T cells, blocking interaction with PD-L1 and PD-L2 and releasing PD-1 pathway-mediated inhibition of antitumor immune responses. |
MoA Biomarker | PD-1 with slow dissociation and preferential binding in TME-mimicking low |
PK/PD Half-life | 25 h |
PK/PD Species | Mouse, Objective response, duration of response, exploratory ctDNA clearance |
PK/PD Animal (cat.) | Mouse |
PK/PD Experiment | PD |
Toxicology Species | Cynomolgus monkey, Macaque, Mouse |
Toxicology Animal (cat.) | NHP |
Toxicology Major finding | Immune-related adverse reactions: pneumonitis, colitis, hepatitis, hypophysitis, thyroid disorders, nephritis, rash. |
Toxicology CRS | N/A (checkpoint inhibitor) |
Clinical Safety signal | Immune-related adverse reactions: pneumonitis, colitis, hepatitis, hypophysitis, thyroid disorders, nephritis, rash. |
Clinical Selected reported efficacy | ORR 100% |
Clinical Reported ORR | 100% |
Clinical Result source | ClinicalTrials.gov NCT03267498 |
Clinical Program phase | APPROVED |
Clinical Trial activity | No active/completed counts |
Clinical Trial ref | NCT03267498 |
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