구조모아 (StructureMoa)항암 chemical structure spider web
방문타깃 · 모달리티 · 임상 근거 · 비임상 맥락으로 최대 5개 프로그램을 나란히 비교합니다. · 다음 갱신 D-6 · 마지막 9월 2일
현재 선택: 1개 · 임상 갱신 필요 1개
프로그램 상세에서 관심 등록 후 2개 이상 모으면 여기서 한 번에 비교할 수 있습니다.
표가 넓으면 좌우로 스크롤하세요. 핵심 비교 모드에서는 중요 항목만 표시됩니다.
| 항목 | Chimeric Antigen Receptor (Chimeric Antigen Receptor) Fondazione Policlinico Universitar…·Lymphoma 91 trials |
|---|---|
Overview Program | Chimeric Antigen Receptor |
Overview Company | Fondazione Policlinico Universitario Agostino Gemelli IRCCS |
Overview Modality | CGT |
Overview Target | Lymphoma |
Overview Indication | Lymphoma |
Overview Phase | PRECLINICAL |
Overview Status | RECRUITING |
Overview Content status | Standard Database |
Overview Data Confidence | Data Confidence · Medium |
Overview Development Signal | Development Signal · Watch |
Overview Approval status | Investigational |
Technology Vector | retroviral therapy (ART)-suppressed, HIV-infected humanized DRAGA mice following ART inter |
MoA Mechanism | targeting chimeric antigen receptor |
MoA Biomarker | biomarker-driven methods were among the clinically orientated themes that emerged from foundational and precl |
PK/PD Species | Mouse |
PK/PD Animal (cat.) | Mouse |
PK/PD Experiment | PK |
Toxicology Species | Mouse |
Toxicology Animal (cat.) | Mouse |
Toxicology Major finding | Early neurologic response predicts outcomes after anakinra for immune effector cell-associated neurotoxicity syndrome.. Anakinra is increasingly used for corticosteroid-refractory and/or severe immune effector cell-associated neurotoxicity syndrome (ICANS) following chimeric antigen receptor (CAR) T-cell therapy; however, robust data on its efficacy and predictors of response are lacking. We evalu… |
Toxicology CRS | Reported |
Clinical Safety signal | Early neurologic response predicts outcomes after anakinra for immune effector cell-associated neurotoxicity syndrome.. Anakinra is increasingly used for corticosteroid-refractory and/or severe immune effector cell-associated neurotoxicity syndrome (ICANS) following chimeric antigen receptor (CAR) T-cell therapy; however, robust data on its efficacy and predictors of response are lacking. We evalu… |
Clinical Selected reported efficacy | ORR 67% |
Clinical Reported ORR | 67% |
Clinical Result source | ClinicalTrials.gov NCT03704298 |
Clinical Program phase | PRECLINICAL |
Clinical Trial ref | NCT03704298 |
타깃 · 모달리티 · 임상 근거 · 비임상 맥락으로 최대 5개 프로그램을 나란히 비교합니다. · 다음 갱신 D-6 · 마지막 9월 2일
현재 선택: 1개 · 임상 갱신 필요 1개
프로그램 상세에서 관심 등록 후 2개 이상 모으면 여기서 한 번에 비교할 수 있습니다.
표가 넓으면 좌우로 스크롤하세요. 핵심 비교 모드에서는 중요 항목만 표시됩니다.
| 항목 | Chimeric Antigen Receptor (Chimeric Antigen Receptor) Fondazione Policlinico Universitar…·Lymphoma 91 trials |
|---|---|
Overview Program | Chimeric Antigen Receptor |
Overview Company | Fondazione Policlinico Universitario Agostino Gemelli IRCCS |
Overview Modality | CGT |
Overview Target | Lymphoma |
Overview Indication | Lymphoma |
Overview Phase | PRECLINICAL |
Overview Status | RECRUITING |
Overview Content status | Standard Database |
Overview Data Confidence | Data Confidence · Medium |
Overview Development Signal | Development Signal · Watch |
Overview Approval status | Investigational |
Technology Vector | retroviral therapy (ART)-suppressed, HIV-infected humanized DRAGA mice following ART inter |
MoA Mechanism | targeting chimeric antigen receptor |
MoA Biomarker | biomarker-driven methods were among the clinically orientated themes that emerged from foundational and precl |
PK/PD Species | Mouse |
PK/PD Animal (cat.) | Mouse |
PK/PD Experiment | PK |
Toxicology Species | Mouse |
Toxicology Animal (cat.) | Mouse |
Toxicology Major finding | Early neurologic response predicts outcomes after anakinra for immune effector cell-associated neurotoxicity syndrome.. Anakinra is increasingly used for corticosteroid-refractory and/or severe immune effector cell-associated neurotoxicity syndrome (ICANS) following chimeric antigen receptor (CAR) T-cell therapy; however, robust data on its efficacy and predictors of response are lacking. We evalu… |
Toxicology CRS | Reported |
Clinical Safety signal | Early neurologic response predicts outcomes after anakinra for immune effector cell-associated neurotoxicity syndrome.. Anakinra is increasingly used for corticosteroid-refractory and/or severe immune effector cell-associated neurotoxicity syndrome (ICANS) following chimeric antigen receptor (CAR) T-cell therapy; however, robust data on its efficacy and predictors of response are lacking. We evalu… |
Clinical Selected reported efficacy | ORR 67% |
Clinical Reported ORR | 67% |
Clinical Result source | ClinicalTrials.gov NCT03704298 |
Clinical Program phase | PRECLINICAL |
Clinical Trial ref | NCT03704298 |
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