구조모아 (StructureMoa)항암 chemical structure spider web
방문프로그램 상세에서 관심 등록 후 2개 이상 모으면 여기서 한 번에 비교할 수 있습니다.
표가 넓으면 좌우로 스크롤하세요. 핵심 비교 모드에서는 중요 항목만 표시됩니다.
| 항목 | ciltacabtagene autoleucel (Carvykti, cilta-cel, LCAR-B38M, JNJ-68284528) Johnson & Johnson / Legend Biotech·BCMA 29 trials·t½ Cellular expansion kinetics rather than classical half-life |
|---|---|
Overview Program | Carvykti (ciltacabtagene autoleucel) |
Overview Company | Johnson & Johnson / Legend Biotech |
Overview Modality | CGT |
Overview Target | BCMA |
Overview Indication | Relapsed or refractory multiple myeloma |
Overview Phase | APPROVED |
Overview Status | APPROVED |
Overview Content status | Curated Core |
Overview Data Confidence | Data Confidence · High |
Overview Development Signal | Development Signal · Established |
Overview Approval status | FDA approved |
Positioning Key differentiator | Dual-epitope BCMA binding raises avidity and appears to sustain CAR-T persistence longer than single-domain designs. |
Positioning Known limitation | BCMA loss or biallelic deletion, soluble BCMA shedding, T-cell exhaustion, and immunosuppressive marrow niche. |
Positioning Development positioning | Best-in-class efficacy in BCMA CAR-T, ahead of Abecma on depth of response. |
Technology Vector | Lentiviral |
MoA Mechanism | Autologous T cells engineered with a dual-epitope BCMA CAR recognize BCMA on malignant plasma cells and trigger MHC-independent cytolysis and clonal CAR-T expansion. |
MoA Biomarker | BCMA expression, MRD negativity at 10⁻⁵, CAR transgene persistence. |
PK/PD Half-life | Cellular expansion kinetics rather than classical half-life |
PK/PD Species | Peak CAR transgene level, MRD negativity, soluble BCMA decline |
PK/PD Animal (cat.) | Human |
PK/PD Experiment | PK |
Toxicology Major finding | Boxed warnings for CRS, ICANS, parkinsonism and Guillain-Barré syndrome, HLH/MAS, prolonged cytopenia, and secondary T-cell malignancy. |
Toxicology CRS | CRS in ~95% of CARTITUDE-1 patients, grade ≥3 ~4% |
Clinical Safety signal | Boxed warnings for CRS, ICANS, parkinsonism and Guillain-Barré syndrome, HLH/MAS, prolonged cytopenia, and secondary T-cell malignancy. |
Clinical Selected reported efficacy | ORR 97% |
Clinical Reported ORR | 97% |
Clinical Reported PFS | HR 0.26 vs standard care in CARTITUDE-4 |
Clinical Reported OS | NA |
Clinical Result source | CARTITUDE-1 (NCT03548207) / CARTITUDE-4 (NCT04181827) |
Clinical Program phase | APPROVED |
Clinical Trial activity | No active/completed counts |
Clinical Trial ref | NCT03548207 |
프로그램 상세에서 관심 등록 후 2개 이상 모으면 여기서 한 번에 비교할 수 있습니다.
표가 넓으면 좌우로 스크롤하세요. 핵심 비교 모드에서는 중요 항목만 표시됩니다.
| 항목 | ciltacabtagene autoleucel (Carvykti, cilta-cel, LCAR-B38M, JNJ-68284528) Johnson & Johnson / Legend Biotech·BCMA 29 trials·t½ Cellular expansion kinetics rather than classical half-life |
|---|---|
Overview Program | Carvykti (ciltacabtagene autoleucel) |
Overview Company | Johnson & Johnson / Legend Biotech |
Overview Modality | CGT |
Overview Target | BCMA |
Overview Indication | Relapsed or refractory multiple myeloma |
Overview Phase | APPROVED |
Overview Status | APPROVED |
Overview Content status | Curated Core |
Overview Data Confidence | Data Confidence · High |
Overview Development Signal | Development Signal · Established |
Overview Approval status | FDA approved |
Positioning Key differentiator | Dual-epitope BCMA binding raises avidity and appears to sustain CAR-T persistence longer than single-domain designs. |
Positioning Known limitation | BCMA loss or biallelic deletion, soluble BCMA shedding, T-cell exhaustion, and immunosuppressive marrow niche. |
Positioning Development positioning | Best-in-class efficacy in BCMA CAR-T, ahead of Abecma on depth of response. |
Technology Vector | Lentiviral |
MoA Mechanism | Autologous T cells engineered with a dual-epitope BCMA CAR recognize BCMA on malignant plasma cells and trigger MHC-independent cytolysis and clonal CAR-T expansion. |
MoA Biomarker | BCMA expression, MRD negativity at 10⁻⁵, CAR transgene persistence. |
PK/PD Half-life | Cellular expansion kinetics rather than classical half-life |
PK/PD Species | Peak CAR transgene level, MRD negativity, soluble BCMA decline |
PK/PD Animal (cat.) | Human |
PK/PD Experiment | PK |
Toxicology Major finding | Boxed warnings for CRS, ICANS, parkinsonism and Guillain-Barré syndrome, HLH/MAS, prolonged cytopenia, and secondary T-cell malignancy. |
Toxicology CRS | CRS in ~95% of CARTITUDE-1 patients, grade ≥3 ~4% |
Clinical Safety signal | Boxed warnings for CRS, ICANS, parkinsonism and Guillain-Barré syndrome, HLH/MAS, prolonged cytopenia, and secondary T-cell malignancy. |
Clinical Selected reported efficacy | ORR 97% |
Clinical Reported ORR | 97% |
Clinical Reported PFS | HR 0.26 vs standard care in CARTITUDE-4 |
Clinical Reported OS | NA |
Clinical Result source | CARTITUDE-1 (NCT03548207) / CARTITUDE-4 (NCT04181827) |
Clinical Program phase | APPROVED |
Clinical Trial activity | No active/completed counts |
Clinical Trial ref | NCT03548207 |
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