타깃 · 모달리티 · 임상 근거 · 비임상 맥락으로 최대 5개 프로그램을 나란히 비교합니다. · 자동 수집 갱신 권장 · 9월 2일
현재 선택: 1개 · 임상 갱신 필요 1개
프로그램 상세에서 관심 등록 후 2개 이상 모으면 여기서 한 번에 비교할 수 있습니다.
표가 넓으면 좌우로 스크롤하세요. 핵심 비교 모드에서는 중요 항목만 표시됩니다.
| 항목 | lifileucel (Amtagvi, LN-144, tumor infiltrating lymphocyte) Iovance Biotherapeutics·Polyclonal tumor neoantigens (TIL) 47 trials |
|---|---|
Overview Program | Amtagvi (lifileucel) |
Overview Company | Iovance Biotherapeutics |
Overview Modality | CGT |
Overview Target | Polyclonal tumor neoantigens (TIL) |
Overview Indication | Unresectable or metastatic melanoma after PD-1 blockade |
Overview Phase | APPROVED |
Overview Status | APPROVED |
Overview Content status | Curated Core |
Overview Data Confidence | Editorial scope · Curated Core |
Overview Development Signal | Development Signal · Established |
Overview Approval status | FDA approved |
Positioning Key differentiator | Polyclonal recognition of private neoantigens instead of one engineered receptor, so it does not depend on a single shared target. |
Positioning Known limitation | Antigen presentation loss (B2M/HLA), TIL exhaustion, and a hostile tumor microenvironment. |
Positioning Development positioning | Post-IO salvage |
MoA Mechanism | Autologous TILs already primed against the patient's tumor are expanded to therapeutic numbers, reinfused after lymphodepletion to clear regulatory cells and cytokine sinks, then supported with IL-2. |
MoA Biomarker | Tumor mutational burden and baseline tumor burden correlate with response; no required companion diagnostic. |
Toxicology Major finding | Boxed warning for treatment-related mortality, prolonged severe cytopenia, severe infection, cardiopulmonary and renal impairment, and internal hemorrhage. Most toxicity comes from lymphodepletion and IL-2, not the TILs themselves. |
Toxicology CRS | Uncommon compared with CAR-T |
Clinical Safety signal | Boxed warning for treatment-related mortality, prolonged severe cytopenia, severe infection, cardiopulmonary and renal impairment, and internal hemorrhage. Most toxicity comes from lymphodepletion and IL-2, not the TILs themselves. |
Clinical Program phase | APPROVED |
Clinical Trial activity | No active/completed counts |
타깃 · 모달리티 · 임상 근거 · 비임상 맥락으로 최대 5개 프로그램을 나란히 비교합니다. · 자동 수집 갱신 권장 · 9월 2일
현재 선택: 1개 · 임상 갱신 필요 1개
프로그램 상세에서 관심 등록 후 2개 이상 모으면 여기서 한 번에 비교할 수 있습니다.
표가 넓으면 좌우로 스크롤하세요. 핵심 비교 모드에서는 중요 항목만 표시됩니다.
| 항목 | lifileucel (Amtagvi, LN-144, tumor infiltrating lymphocyte) Iovance Biotherapeutics·Polyclonal tumor neoantigens (TIL) 47 trials |
|---|---|
Overview Program | Amtagvi (lifileucel) |
Overview Company | Iovance Biotherapeutics |
Overview Modality | CGT |
Overview Target | Polyclonal tumor neoantigens (TIL) |
Overview Indication | Unresectable or metastatic melanoma after PD-1 blockade |
Overview Phase | APPROVED |
Overview Status | APPROVED |
Overview Content status | Curated Core |
Overview Data Confidence | Editorial scope · Curated Core |
Overview Development Signal | Development Signal · Established |
Overview Approval status | FDA approved |
Positioning Key differentiator | Polyclonal recognition of private neoantigens instead of one engineered receptor, so it does not depend on a single shared target. |
Positioning Known limitation | Antigen presentation loss (B2M/HLA), TIL exhaustion, and a hostile tumor microenvironment. |
Positioning Development positioning | Post-IO salvage |
MoA Mechanism | Autologous TILs already primed against the patient's tumor are expanded to therapeutic numbers, reinfused after lymphodepletion to clear regulatory cells and cytokine sinks, then supported with IL-2. |
MoA Biomarker | Tumor mutational burden and baseline tumor burden correlate with response; no required companion diagnostic. |
Toxicology Major finding | Boxed warning for treatment-related mortality, prolonged severe cytopenia, severe infection, cardiopulmonary and renal impairment, and internal hemorrhage. Most toxicity comes from lymphodepletion and IL-2, not the TILs themselves. |
Toxicology CRS | Uncommon compared with CAR-T |
Clinical Safety signal | Boxed warning for treatment-related mortality, prolonged severe cytopenia, severe infection, cardiopulmonary and renal impairment, and internal hemorrhage. Most toxicity comes from lymphodepletion and IL-2, not the TILs themselves. |
Clinical Program phase | APPROVED |
Clinical Trial activity | No active/completed counts |
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