구조모아 (StructureMoa)항암 chemical structure spider web
방문타깃 · 모달리티 · 임상 근거 · 비임상 맥락으로 최대 5개 프로그램을 나란히 비교합니다. · 다음 갱신 D-6 · 마지막 9월 2일
현재 선택: 1개 · 임상 갱신 필요 1개
프로그램 상세에서 관심 등록 후 2개 이상 모으면 여기서 한 번에 비교할 수 있습니다.
표가 넓으면 좌우로 스크롤하세요. 핵심 비교 모드에서는 중요 항목만 표시됩니다.
| 항목 | |
|---|---|
Overview Program | tamoxifen citrate |
Overview Company | Gamma Medica-Ideas |
Overview Modality | CGT |
Overview Target | Breast Cancer |
Overview Indication | Male Breast Cancer; Stage II Breast Cancer |
Overview Phase | PHASE_2 |
Overview Status | ACTIVE |
Overview Content status | Standard Database |
Overview Data Confidence | Data Confidence · Medium |
Overview Development Signal | Development Signal · Emerging |
Overview Approval status | Investigational |
Technology Vector | lipid nanoparticles as a targeted chemotherapeutic drug |
MoA Mechanism | target genes in hyaloid endothelial cells, consistent with a role for GPR124 in mediating WNT/β-catenin signaling |
MoA Biomarker | HER2) negativity and a low |
PK/PD Half-life | 7 h |
PK/PD Species | Mouse |
PK/PD Animal (cat.) | Mouse |
PK/PD Experiment | pharmacokinetic |
Toxicology Species | Mouse |
Toxicology Animal (cat.) | Mouse |
Toxicology Major finding | Human serum albumin-based polymeric nanoparticles for ratiometric co-encapsulation and co-delivery of palbociclib and tamoxifen citrate for synergistic effect in breast cancer management.. In conventional co-delivered chemotherapeutic strategies, the disparity in physicochemical properties and non-coordinated pharmacokinetic profile is largely overlooked. To overcome these long-standing challenges… |
Clinical Safety signal | Human serum albumin-based polymeric nanoparticles for ratiometric co-encapsulation and co-delivery of palbociclib and tamoxifen citrate for synergistic effect in breast cancer management.. In conventional co-delivered chemotherapeutic strategies, the disparity in physicochemical properties and non-coordinated pharmacokinetic profile is largely overlooked. To overcome these long-standing challenges… |
Clinical Selected reported efficacy | ORR 13% |
Clinical Reported ORR | 13% |
Clinical Result source | ClinicalTrials.gov NCT02806544 |
Clinical Program phase | PHASE_2 |
Clinical Trial ref | NCT02806544 |
타깃 · 모달리티 · 임상 근거 · 비임상 맥락으로 최대 5개 프로그램을 나란히 비교합니다. · 다음 갱신 D-6 · 마지막 9월 2일
현재 선택: 1개 · 임상 갱신 필요 1개
프로그램 상세에서 관심 등록 후 2개 이상 모으면 여기서 한 번에 비교할 수 있습니다.
표가 넓으면 좌우로 스크롤하세요. 핵심 비교 모드에서는 중요 항목만 표시됩니다.
| 항목 | |
|---|---|
Overview Program | tamoxifen citrate |
Overview Company | Gamma Medica-Ideas |
Overview Modality | CGT |
Overview Target | Breast Cancer |
Overview Indication | Male Breast Cancer; Stage II Breast Cancer |
Overview Phase | PHASE_2 |
Overview Status | ACTIVE |
Overview Content status | Standard Database |
Overview Data Confidence | Data Confidence · Medium |
Overview Development Signal | Development Signal · Emerging |
Overview Approval status | Investigational |
Technology Vector | lipid nanoparticles as a targeted chemotherapeutic drug |
MoA Mechanism | target genes in hyaloid endothelial cells, consistent with a role for GPR124 in mediating WNT/β-catenin signaling |
MoA Biomarker | HER2) negativity and a low |
PK/PD Half-life | 7 h |
PK/PD Species | Mouse |
PK/PD Animal (cat.) | Mouse |
PK/PD Experiment | pharmacokinetic |
Toxicology Species | Mouse |
Toxicology Animal (cat.) | Mouse |
Toxicology Major finding | Human serum albumin-based polymeric nanoparticles for ratiometric co-encapsulation and co-delivery of palbociclib and tamoxifen citrate for synergistic effect in breast cancer management.. In conventional co-delivered chemotherapeutic strategies, the disparity in physicochemical properties and non-coordinated pharmacokinetic profile is largely overlooked. To overcome these long-standing challenges… |
Clinical Safety signal | Human serum albumin-based polymeric nanoparticles for ratiometric co-encapsulation and co-delivery of palbociclib and tamoxifen citrate for synergistic effect in breast cancer management.. In conventional co-delivered chemotherapeutic strategies, the disparity in physicochemical properties and non-coordinated pharmacokinetic profile is largely overlooked. To overcome these long-standing challenges… |
Clinical Selected reported efficacy | ORR 13% |
Clinical Reported ORR | 13% |
Clinical Result source | ClinicalTrials.gov NCT02806544 |
Clinical Program phase | PHASE_2 |
Clinical Trial ref | NCT02806544 |
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