구조모아 (StructureMoa)항암 chemical structure spider web
방문타깃 · 모달리티 · 임상 근거 · 비임상 맥락으로 최대 5개 프로그램을 나란히 비교합니다. · 다음 갱신 D-6 · 마지막 9월 2일
현재 선택: 1개 · 임상 갱신 필요 1개
프로그램 상세에서 관심 등록 후 2개 이상 모으면 여기서 한 번에 비교할 수 있습니다.
표가 넓으면 좌우로 스크롤하세요. 핵심 비교 모드에서는 중요 항목만 표시됩니다.
| 항목 | |
|---|---|
Overview Program | Rintatolimod |
Overview Company | Roswell Park Cancer Institute |
Overview Modality | CGT |
Overview Target | HER2 |
Overview Indication | Malignant Neoplasm of Pancreas Metastatic to Peritoneal Surface; Malignant Peritoneal Mesothelioma |
Overview Phase | PHASE_2 |
Overview Status | ACTIVE |
Overview Content status | Standard Database |
Overview Data Confidence | Data Confidence · Medium |
Overview Development Signal | Development Signal · Emerging |
Overview Approval status | Investigational |
Toxicology Major finding | Synergy between TLR3-ligand and IFN-α in the transient sensitization of "Cold" tumors to PD-1 blockade and the induction of systemic immunity.. Programmed cell death protein-1 (PD-1)-blocking immune checkpoint inhibitors (ICIs) are effective against highly immunogenic "hot" tumors containing high numbers of cytotoxic T-lymphocytes (CTLs), but not against poorly immunogenic "cold" tumors. We … |
Clinical Safety signal | Synergy between TLR3-ligand and IFN-α in the transient sensitization of "Cold" tumors to PD-1 blockade and the induction of systemic immunity.. Programmed cell death protein-1 (PD-1)-blocking immune checkpoint inhibitors (ICIs) are effective against highly immunogenic "hot" tumors containing high numbers of cytotoxic T-lymphocytes (CTLs), but not against poorly immunogenic "cold" tumors. We … |
Clinical Reported ORR | 0% |
Clinical Result source | ClinicalTrials.gov NCT03403634 |
Clinical Program phase | PHASE_2 |
Clinical Trial ref | NCT03403634 |
타깃 · 모달리티 · 임상 근거 · 비임상 맥락으로 최대 5개 프로그램을 나란히 비교합니다. · 다음 갱신 D-6 · 마지막 9월 2일
현재 선택: 1개 · 임상 갱신 필요 1개
프로그램 상세에서 관심 등록 후 2개 이상 모으면 여기서 한 번에 비교할 수 있습니다.
표가 넓으면 좌우로 스크롤하세요. 핵심 비교 모드에서는 중요 항목만 표시됩니다.
| 항목 | |
|---|---|
Overview Program | Rintatolimod |
Overview Company | Roswell Park Cancer Institute |
Overview Modality | CGT |
Overview Target | HER2 |
Overview Indication | Malignant Neoplasm of Pancreas Metastatic to Peritoneal Surface; Malignant Peritoneal Mesothelioma |
Overview Phase | PHASE_2 |
Overview Status | ACTIVE |
Overview Content status | Standard Database |
Overview Data Confidence | Data Confidence · Medium |
Overview Development Signal | Development Signal · Emerging |
Overview Approval status | Investigational |
Toxicology Major finding | Synergy between TLR3-ligand and IFN-α in the transient sensitization of "Cold" tumors to PD-1 blockade and the induction of systemic immunity.. Programmed cell death protein-1 (PD-1)-blocking immune checkpoint inhibitors (ICIs) are effective against highly immunogenic "hot" tumors containing high numbers of cytotoxic T-lymphocytes (CTLs), but not against poorly immunogenic "cold" tumors. We … |
Clinical Safety signal | Synergy between TLR3-ligand and IFN-α in the transient sensitization of "Cold" tumors to PD-1 blockade and the induction of systemic immunity.. Programmed cell death protein-1 (PD-1)-blocking immune checkpoint inhibitors (ICIs) are effective against highly immunogenic "hot" tumors containing high numbers of cytotoxic T-lymphocytes (CTLs), but not against poorly immunogenic "cold" tumors. We … |
Clinical Reported ORR | 0% |
Clinical Result source | ClinicalTrials.gov NCT03403634 |
Clinical Program phase | PHASE_2 |
Clinical Trial ref | NCT03403634 |
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