구조모아 (StructureMoa)항암 chemical structure spider web
방문타깃 · 모달리티 · 임상 근거 · 비임상 맥락으로 최대 5개 프로그램을 나란히 비교합니다. · 다음 갱신 D-6 · 마지막 9월 2일
현재 선택: 1개 · 임상 갱신 필요 1개
프로그램 상세에서 관심 등록 후 2개 이상 모으면 여기서 한 번에 비교할 수 있습니다.
표가 넓으면 좌우로 스크롤하세요. 핵심 비교 모드에서는 중요 항목만 표시됩니다.
| 항목 | methadone hydrochloride (methadone hydrochloride) National Institute on Drug Abuse (…·Brain and Central Nervous System T… 61 trials·t½ 2.0 h |
|---|---|
Overview Program | methadone hydrochloride |
Overview Company | National Institute on Drug Abuse (NIDA) |
Overview Modality | CGT |
Overview Target | Brain and Central Nervous System Tumors |
Overview Indication | Brain and Central Nervous System Tumors; Chronic Myeloproliferative Disorders |
Overview Phase | PRECLINICAL |
Overview Status | DISCONTINUED |
Overview Content status | Standard Database |
Overview Data Confidence | Data Confidence · Medium |
Overview Development Signal | Development Signal · Watch |
Overview Approval status | Investigational |
MoA Mechanism | target MORs such as novel low-efficacy MOR agonists or long-acting formulations, and (3) medications that target post-MOR signaling |
MoA Biomarker | biomarkers, long-term safety profiling, sex-specific responses, and real-world effectiveness studies |
PK/PD Half-life | 2.0 h |
PK/PD Species | Dog, Ferret |
PK/PD Animal (cat.) | Dog |
PK/PD Experiment | Pharmacokinetic |
Toxicology Species | Dog, Ferret |
Toxicology Animal (cat.) | Dog |
Toxicology Major finding | Evaluation of thermal antinociceptive effects after intramuscular administration of methadone hydrochloride to orange-winged Amazon parrots (Amazona amazonica).. To evaluate the thermal antinociceptive effects of methadone after IM administration to orange-winged Amazon parrots (Amazona amazonica). 8 Amazon parrots received IM methadone hydrochloride (1, 3, and 6 mg/kg) and saline (0.9% NaCl) solu… |
Clinical Safety signal | Evaluation of thermal antinociceptive effects after intramuscular administration of methadone hydrochloride to orange-winged Amazon parrots (Amazona amazonica).. To evaluate the thermal antinociceptive effects of methadone after IM administration to orange-winged Amazon parrots (Amazona amazonica). 8 Amazon parrots received IM methadone hydrochloride (1, 3, and 6 mg/kg) and saline (0.9% NaCl) solu… |
Clinical Selected reported efficacy | ORR 13.7% |
Clinical Reported ORR | 13.7% |
Clinical Result source | ClinicalTrials.gov NCT00386243 |
Clinical Program phase | PRECLINICAL |
Clinical Trial ref | NCT00386243 |
타깃 · 모달리티 · 임상 근거 · 비임상 맥락으로 최대 5개 프로그램을 나란히 비교합니다. · 다음 갱신 D-6 · 마지막 9월 2일
현재 선택: 1개 · 임상 갱신 필요 1개
프로그램 상세에서 관심 등록 후 2개 이상 모으면 여기서 한 번에 비교할 수 있습니다.
표가 넓으면 좌우로 스크롤하세요. 핵심 비교 모드에서는 중요 항목만 표시됩니다.
| 항목 | methadone hydrochloride (methadone hydrochloride) National Institute on Drug Abuse (…·Brain and Central Nervous System T… 61 trials·t½ 2.0 h |
|---|---|
Overview Program | methadone hydrochloride |
Overview Company | National Institute on Drug Abuse (NIDA) |
Overview Modality | CGT |
Overview Target | Brain and Central Nervous System Tumors |
Overview Indication | Brain and Central Nervous System Tumors; Chronic Myeloproliferative Disorders |
Overview Phase | PRECLINICAL |
Overview Status | DISCONTINUED |
Overview Content status | Standard Database |
Overview Data Confidence | Data Confidence · Medium |
Overview Development Signal | Development Signal · Watch |
Overview Approval status | Investigational |
MoA Mechanism | target MORs such as novel low-efficacy MOR agonists or long-acting formulations, and (3) medications that target post-MOR signaling |
MoA Biomarker | biomarkers, long-term safety profiling, sex-specific responses, and real-world effectiveness studies |
PK/PD Half-life | 2.0 h |
PK/PD Species | Dog, Ferret |
PK/PD Animal (cat.) | Dog |
PK/PD Experiment | Pharmacokinetic |
Toxicology Species | Dog, Ferret |
Toxicology Animal (cat.) | Dog |
Toxicology Major finding | Evaluation of thermal antinociceptive effects after intramuscular administration of methadone hydrochloride to orange-winged Amazon parrots (Amazona amazonica).. To evaluate the thermal antinociceptive effects of methadone after IM administration to orange-winged Amazon parrots (Amazona amazonica). 8 Amazon parrots received IM methadone hydrochloride (1, 3, and 6 mg/kg) and saline (0.9% NaCl) solu… |
Clinical Safety signal | Evaluation of thermal antinociceptive effects after intramuscular administration of methadone hydrochloride to orange-winged Amazon parrots (Amazona amazonica).. To evaluate the thermal antinociceptive effects of methadone after IM administration to orange-winged Amazon parrots (Amazona amazonica). 8 Amazon parrots received IM methadone hydrochloride (1, 3, and 6 mg/kg) and saline (0.9% NaCl) solu… |
Clinical Selected reported efficacy | ORR 13.7% |
Clinical Reported ORR | 13.7% |
Clinical Result source | ClinicalTrials.gov NCT00386243 |
Clinical Program phase | PRECLINICAL |
Clinical Trial ref | NCT00386243 |
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