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항목
CGTStandard DatabasestalePhase 2
TK-deletion plus GM-CSF (JX-594: Recombinant vaccinia virus, JX-594: Recombinant vaccinia virus (TK-deletion plus GM-CSF))
Green Cross Corporation·Carcinoma, Hepatocellular
14 trials
Overview
Program
JX-594: Recombinant vaccinia virus (TK-deletion plus GM-CSF)
Overview
Company
Green Cross Corporation
Overview
Modality
CGT
Overview
Target
Carcinoma, Hepatocellular
Overview
Indication
Carcinoma, Hepatocellular
Overview
Phase
PHASE_2
Overview
Status
ACTIVE
Overview
Content status
Standard Database
Overview
Data Confidence
Data Confidence · Medium
Overview
Development Signal
Development Signal · Emerging
Overview
Approval status
Investigational
Toxicology
Major finding
Using Computer Modeling and Experimental Methods to Screen for Aptamers That Bind to the VV-GMCSF-LACT Virus.. Oncolytic virotherapy is a promising approach for cancer treatment. However, when introduced into the body, the virus provokes the production of virus-neutralizing antibodies, which can reduce its antitumor effect. To shield viruses from the immune system, aptamers that can cover the memb…
Clinical
Safety signal
Using Computer Modeling and Experimental Methods to Screen for Aptamers That Bind to the VV-GMCSF-LACT Virus.. Oncolytic virotherapy is a promising approach for cancer treatment. However, when introduced into the body, the virus provokes the production of virus-neutralizing antibodies, which can reduce its antitumor effect. To shield viruses from the immune system, aptamers that can cover the memb…
Clinical
Selected reported efficacy
ORR 19.2%
Clinical
Reported ORR
19.2%
Clinical
Result source
ClinicalTrials.gov NCT02562755
Clinical
Program phase
PHASE_2
Clinical
Trial ref
NCT02562755
JX-594: Recombinant vaccinia virus (TK-deletion plus GM-CSF) 비교 | 바이오정보모아