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항목
CGTStandard DatabasestalePreclinical
FGFR Inhibitor AZD4547 (FGFR Inhibitor AZD4547)
SWOG Cancer Research Network·Recurrent Squamous Cell Lung Carci…
19 trials
Overview
Program
FGFR Inhibitor AZD4547
Overview
Company
SWOG Cancer Research Network
Overview
Modality
CGT
Overview
Target
Recurrent Squamous Cell Lung Carcinoma
Overview
Indication
Recurrent Squamous Cell Lung Carcinoma; Stage IV Squamous Cell Lung Carcinoma AJCC v7
Overview
Phase
PRECLINICAL
Overview
Status
ACTIVE
Overview
Content status
Standard Database
Overview
Data Confidence
Data Confidence · Medium
Overview
Development Signal
Development Signal · Watch
Overview
Approval status
Investigational
Toxicology
Major finding
Results of the phase IIa RADICAL trial of the FGFR inhibitor AZD4547 in endocrine resistant breast cancer.. We conducted a phase IIa, multi-centre, open label, single arm study (RADICAL; NCT01791985) of AZD4547 (a potent and selective inhibitor of Fibroblast Growth Factor Receptor (FGFR)-1, 2 and 3 receptor tyrosine kinases) administered with anastrozole or letrozole in estrogen receptor positive …
Clinical
Safety signal
Results of the phase IIa RADICAL trial of the FGFR inhibitor AZD4547 in endocrine resistant breast cancer.. We conducted a phase IIa, multi-centre, open label, single arm study (RADICAL; NCT01791985) of AZD4547 (a potent and selective inhibitor of Fibroblast Growth Factor Receptor (FGFR)-1, 2 and 3 receptor tyrosine kinases) administered with anastrozole or letrozole in estrogen receptor positive …
Clinical
Selected reported efficacy
ORR 8%
Clinical
Reported ORR
8%
Clinical
Result source
ClinicalTrials.gov NCT04439240
Clinical
Program phase
PRECLINICAL
Clinical
Trial ref
NCT04439240