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검색으로 10,000+ 프로그램 중 최대 5개를 골라 PK/PD · 독성 · 임상을 나란히 비교합니다. · 다음 갱신 D-8 · 마지막 7월 21일

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항목
AntibodyPhase 3
Belzutifan (Belzutifan)
Merck Sharp & Dohme LLC·Carcinoma, Renal Cell
ORR 21.9%·t½ 38 h
Overview
Program
Belzutifan
Overview
Company
Merck Sharp & Dohme LLC
Overview
Modality
ANTIBODY
Overview
Target
Carcinoma, Renal Cell
Overview
Indication
Carcinoma, Renal Cell
Overview
Phase
PHASE_3
Overview
Status
RECRUITING
MoA
Mechanism
targeting these pathways are often limited by asynchronous drug decay and adaptive signaling
MoA
Biomarker
PD-L1 expression
PK/PD
Half-life
38 h
PK/PD
Species
Rat, Human, Discovery of NKT2152, a Potent and Selective HIF-2&#x3b1
PK/PD
Animal (cat.)
Human, Rat, In vitro
PK/PD
Experiment
Pharmacokinetic
Toxicology
Species
Rat, Human, Discovery of NKT2152, a Potent and Selective HIF-2&#x3b1
Toxicology
Animal (cat.)
Human, Rat, In vitro
Toxicology
Major finding
Adjuvant Pembrolizumab plus Belzutifan for Renal-Cell Carcinoma.. Adjuvant pembrolizumab improves disease-free and overall survival among patients with resected clear-cell renal-cell carcinoma. The hypoxia-inducible factor 2α inhibitor belzutifan has activity in advanced disease. Adjuvant pembrolizumab with belzutifan may further improve outcomes in patients with clear-cell renal-cell carcin…
Clinical
Primary efficacy
ORR 21.9%
Clinical
ORR
21.9%
Clinical
Result source
ClinicalTrials.gov NCT04195750
Clinical
Data Tier / Score
A · 47
Clinical
Program phase
PHASE_3
Clinical
Clinical sync
2026년 7월 18일 (8일 전)