구조모아 (StructureMoa)항암 chemical structure spider web
방문타깃 · 모달리티 · 임상 근거 · 비임상 맥락으로 최대 5개 프로그램을 나란히 비교합니다. · 다음 갱신 D-6 · 마지막 9월 2일
현재 선택: 1개 · 임상 갱신 필요 1개
프로그램 상세에서 관심 등록 후 2개 이상 모으면 여기서 한 번에 비교할 수 있습니다.
표가 넓으면 좌우로 스크롤하세요. 핵심 비교 모드에서는 중요 항목만 표시됩니다.
| 항목 | Anti-Thymocyte Globulin (Anti-Thymocyte Globulin) Sumitomo Pharma Switzerland GmbH·End Stage Renal Disease 125 trials·t½ 3 h |
|---|---|
Overview Program | Anti-Thymocyte Globulin |
Overview Company | Sumitomo Pharma Switzerland GmbH |
Overview Modality | ANTIBODY |
Overview Target | End Stage Renal Disease |
Overview Indication | Leukemia; Lymphoma |
Overview Phase | PHASE_2 |
Overview Status | ACTIVE |
Overview Content status | Limited Data |
Overview Data Confidence | Data Confidence · Low |
Overview Development Signal | Development Signal · Emerging |
Overview Approval status | Investigational |
MoA Mechanism | The mechanism of action by which polyclonal antilymphocyte preparations suppress immune responses is not fully understood |
MoA Biomarker | biomarkers |
PK/PD Half-life | 3 h |
PK/PD Species | Rabbit, Human |
PK/PD Animal (cat.) | Human, In vitro |
PK/PD Experiment | pharmacokinetic |
Toxicology Species | Rabbit, Human |
Toxicology Animal (cat.) | Human, In vitro |
Toxicology Major finding | High Predicted Thiotepa Exposure is Associated with Increased Risk of Thrombotic Microangiopathy and Non-Relapse Mortality in Pediatric Patients Undergoing Alpha-Beta T-Cell Depleted Haploidentical Transplantation.. Thiotepa is commonly included in combination with other agents to prevent rejection and relapse following alpha-beta-T-cell/CD19-depleted (AB-TCD) haploidentical hematopoietic cell tra… |
Toxicology CRS | 10% |
Clinical Safety signal | High Predicted Thiotepa Exposure is Associated with Increased Risk of Thrombotic Microangiopathy and Non-Relapse Mortality in Pediatric Patients Undergoing Alpha-Beta T-Cell Depleted Haploidentical Transplantation.. Thiotepa is commonly included in combination with other agents to prevent rejection and relapse following alpha-beta-T-cell/CD19-depleted (AB-TCD) haploidentical hematopoietic cell tra… |
Clinical Selected reported efficacy | ORR 32% |
Clinical Reported ORR | 32% |
Clinical Result source | ClinicalTrials.gov NCT00822770 |
Clinical Program phase | PHASE_2 |
Clinical Trial activity | No active/completed counts |
Clinical Trial ref | NCT00822770 |
타깃 · 모달리티 · 임상 근거 · 비임상 맥락으로 최대 5개 프로그램을 나란히 비교합니다. · 다음 갱신 D-6 · 마지막 9월 2일
현재 선택: 1개 · 임상 갱신 필요 1개
프로그램 상세에서 관심 등록 후 2개 이상 모으면 여기서 한 번에 비교할 수 있습니다.
표가 넓으면 좌우로 스크롤하세요. 핵심 비교 모드에서는 중요 항목만 표시됩니다.
| 항목 | Anti-Thymocyte Globulin (Anti-Thymocyte Globulin) Sumitomo Pharma Switzerland GmbH·End Stage Renal Disease 125 trials·t½ 3 h |
|---|---|
Overview Program | Anti-Thymocyte Globulin |
Overview Company | Sumitomo Pharma Switzerland GmbH |
Overview Modality | ANTIBODY |
Overview Target | End Stage Renal Disease |
Overview Indication | Leukemia; Lymphoma |
Overview Phase | PHASE_2 |
Overview Status | ACTIVE |
Overview Content status | Limited Data |
Overview Data Confidence | Data Confidence · Low |
Overview Development Signal | Development Signal · Emerging |
Overview Approval status | Investigational |
MoA Mechanism | The mechanism of action by which polyclonal antilymphocyte preparations suppress immune responses is not fully understood |
MoA Biomarker | biomarkers |
PK/PD Half-life | 3 h |
PK/PD Species | Rabbit, Human |
PK/PD Animal (cat.) | Human, In vitro |
PK/PD Experiment | pharmacokinetic |
Toxicology Species | Rabbit, Human |
Toxicology Animal (cat.) | Human, In vitro |
Toxicology Major finding | High Predicted Thiotepa Exposure is Associated with Increased Risk of Thrombotic Microangiopathy and Non-Relapse Mortality in Pediatric Patients Undergoing Alpha-Beta T-Cell Depleted Haploidentical Transplantation.. Thiotepa is commonly included in combination with other agents to prevent rejection and relapse following alpha-beta-T-cell/CD19-depleted (AB-TCD) haploidentical hematopoietic cell tra… |
Toxicology CRS | 10% |
Clinical Safety signal | High Predicted Thiotepa Exposure is Associated with Increased Risk of Thrombotic Microangiopathy and Non-Relapse Mortality in Pediatric Patients Undergoing Alpha-Beta T-Cell Depleted Haploidentical Transplantation.. Thiotepa is commonly included in combination with other agents to prevent rejection and relapse following alpha-beta-T-cell/CD19-depleted (AB-TCD) haploidentical hematopoietic cell tra… |
Clinical Selected reported efficacy | ORR 32% |
Clinical Reported ORR | 32% |
Clinical Result source | ClinicalTrials.gov NCT00822770 |
Clinical Program phase | PHASE_2 |
Clinical Trial activity | No active/completed counts |
Clinical Trial ref | NCT00822770 |
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