검색으로 10,000+ 프로그램 중 최대 5개를 골라 PK/PD · 독성 · 임상을 나란히 비교합니다. · 다음 갱신 D-8 · 마지막 7월 21일
현재 선택: 1개
프로그램 상세에서 관심 등록 후 2개 이상 모으면 여기서 한 번에 비교할 수 있습니다.
표가 넓으면 좌우로 스크롤하세요. 핵심 비교 모드에서는 중요 항목만 표시됩니다.
| 항목 | |
|---|---|
Overview Program | 5-fluorouracil (5-FU) |
Overview Company | Merck Sharp & Dohme LLC |
Overview Modality | ADC |
Overview Target | Colorectal Cancer |
Overview Indication | Gastroesophageal Junction; Gastroesophageal Adenocarcinoma |
Overview Phase | PHASE_2 |
Overview Status | RECRUITING |
MoA Mechanism | inhibits GC cell proliferation and induces apoptosis by regulating cell-cycle checkpoints and inhibiting oncogenic pathway |
MoA Biomarker | biomarker for metabolic state, B-cell/TLS-associated immune features, and vulnerability to DNA damage-based t |
PK/PD Species | Rabbit, ration, inhibited xenograft |
PK/PD Animal (cat.) | In vitro |
PK/PD Experiment | pharmacokinetic |
Toxicology Species | Rabbit, ration, inhibited xenograft |
Toxicology Animal (cat.) | In vitro |
Toxicology Major finding | Green synthesized cobalt doped graphene quantum dots derived from Boswellia serrata for dual ligand targeted bioimaging and delivery of exemestane.. Major objective of hydrothermal method is to achieve the synthesis of Cobalt doped Graphene quantum dots (Co-GQDs) using natural precursor (Boswellia serrata gum resin). The Co-GQDs were surface engineered with folic acid (FA) and hyaluronic acid (HA)… |
Clinical Primary efficacy | ORR 72.7% |
Clinical ORR | 72.7% |
Clinical PFS | 10.41 |
Clinical OS | 19.7 |
Clinical Result source | ClinicalTrials.gov NCT04363801 |
Clinical Data Tier / Score | A · 68 |
Clinical Program phase | PHASE_2 |
Clinical Clinical sync | 2026년 7월 18일 (8일 전) |
검색으로 10,000+ 프로그램 중 최대 5개를 골라 PK/PD · 독성 · 임상을 나란히 비교합니다. · 다음 갱신 D-8 · 마지막 7월 21일
현재 선택: 1개
프로그램 상세에서 관심 등록 후 2개 이상 모으면 여기서 한 번에 비교할 수 있습니다.
표가 넓으면 좌우로 스크롤하세요. 핵심 비교 모드에서는 중요 항목만 표시됩니다.
| 항목 | |
|---|---|
Overview Program | 5-fluorouracil (5-FU) |
Overview Company | Merck Sharp & Dohme LLC |
Overview Modality | ADC |
Overview Target | Colorectal Cancer |
Overview Indication | Gastroesophageal Junction; Gastroesophageal Adenocarcinoma |
Overview Phase | PHASE_2 |
Overview Status | RECRUITING |
MoA Mechanism | inhibits GC cell proliferation and induces apoptosis by regulating cell-cycle checkpoints and inhibiting oncogenic pathway |
MoA Biomarker | biomarker for metabolic state, B-cell/TLS-associated immune features, and vulnerability to DNA damage-based t |
PK/PD Species | Rabbit, ration, inhibited xenograft |
PK/PD Animal (cat.) | In vitro |
PK/PD Experiment | pharmacokinetic |
Toxicology Species | Rabbit, ration, inhibited xenograft |
Toxicology Animal (cat.) | In vitro |
Toxicology Major finding | Green synthesized cobalt doped graphene quantum dots derived from Boswellia serrata for dual ligand targeted bioimaging and delivery of exemestane.. Major objective of hydrothermal method is to achieve the synthesis of Cobalt doped Graphene quantum dots (Co-GQDs) using natural precursor (Boswellia serrata gum resin). The Co-GQDs were surface engineered with folic acid (FA) and hyaluronic acid (HA)… |
Clinical Primary efficacy | ORR 72.7% |
Clinical ORR | 72.7% |
Clinical PFS | 10.41 |
Clinical OS | 19.7 |
Clinical Result source | ClinicalTrials.gov NCT04363801 |
Clinical Data Tier / Score | A · 68 |
Clinical Program phase | PHASE_2 |
Clinical Clinical sync | 2026년 7월 18일 (8일 전) |
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